Malignant transformation of oral leukoplakia: a systematic review of observational studies

2015 ◽  
Vol 45 (3) ◽  
pp. 155-166 ◽  
Author(s):  
S. Warnakulasuriya ◽  
A. Ariyawardana
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Observational Studies ◽  
Oral Leukoplakia

scholarly journals Malignant Transformation Rate in Patients Presenting Oral Epithelial Dysplasia: Systematic Review and Meta-Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Jaffer A. Shariff ◽  
Athanasios I. Zavras
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Observational Studies ◽  
Meta Analysis ◽  
Epithelial Dysplasia ◽  
High Rate ◽  
Transformation Rate ◽  
Oral Epithelial Dysplasia ◽  
Observational Cohort ◽  
Oral Epithelial

Objective. To perform a systematic review and meta-analysis on studies that assess malignant transformation rates (MTR) of oral epithelial dysplasia. Materials and Methods. This review was planned and conducted in accordance with the meta-analysis of observational studies in epidemiology (MOOSE) guidelines. PubMed, EMBASE, Google Scholar, and Cochrane databases were screened to identify observational studies. Quality assessments were completed by two reviewers independently using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Pooled-malignant transformation rate (MTR) in person years, subgroup, sensitivity, and publication bias analysis were calculated using STATA 13.0 and Comprehensive Meta-Analysis software. Results. Sixteen observational cohort studies were identified with a total of 3708 participants from Asia, North America, and Europe. Analysis showed a MTR of 10.5% (pooled-MTR: 10.5, 95% CI: 3.7 to 17.3; fixed effect model, I2=0.0%; Q-value = 2.389; p>0.05) among patients with histologically confirmed oral epithelia dysplasia undergoing long-term follow-up. Higher MTR in person year were seen among the sever dysplastic cases (pooled-MTR: 14.4%, 95% CI: 5.3% to 23.5%), studies published in Europe (pooled-MTR: 12.6%, 95% CI: 8.0% to 24.3%), and retrospective studies (pooled-MTR: 11.0%, 95% CI: 2.2% to 19.9%). Conclusion. These studies show that oral epithelial dysplasia has a significant high rate of transformation to cancer.

Laser excision of oral leukoplakia: Does it affect recurrence and malignant transformation? A systematic review and meta-analysis

Oral Oncology ◽  
2020 ◽  
Vol 109 ◽  
pp. 104850
Author(s):  
Mariana de Pauli Paglioni ◽  
Cesar Augusto Migliorati ◽  
Isabel Schausltz Pereira Faustino ◽  
Bruno Augusto Linhares Almeida Mariz ◽  
Ana Luiza Oliveira Corrêa Roza ◽  
...  
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Meta Analysis ◽  
Oral Leukoplakia ◽  
Laser Excision

Malignant transformation of actinic cheilitis: A systematic review of observational studies

2018 ◽  
Vol 9 (4) ◽  
pp. e12343 ◽  
Author(s):  
Alex Dancyger ◽  
Victoria Heard ◽  
Baikai Huang ◽  
Cameron Suley ◽  
Dorothy Tang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Observational Studies ◽  
Actinic Cheilitis

scholarly journals Malignant transformation rate of oral leukoplakia—systematic review

2020 ◽  
Vol 129 (6) ◽  
pp. 600-611.e2 ◽  
Author(s):  
Ana Catarina Pinto ◽  
João Caramês ◽  
Helena Francisco ◽  
André Chen ◽  
António Mano Azul ◽  
...  
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Oral Leukoplakia ◽  
Transformation Rate

scholarly journals Role of Candida infection in the malignant transformation of oral leukoplakia: A systematic review of observational studies

2019 ◽  
Vol 4 ◽  
pp. 2057178X1982822 ◽  
Author(s):  
Khilan Shukla ◽  
Ida Vun ◽  
Ivan Lov ◽  
George Laparidis ◽  
Caitlin McCamley ◽  
...  
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Candida Infection ◽  
Oral Leukoplakia ◽  
Medical Subject Heading ◽  
Exclusion Criteria ◽  
Candidal Infection ◽  
Transformation Rates

The aim of this systematic review was to investigate the malignant transformation of oral leukoplakia (OL) infected with Candida. Literature search was conducted using Medical Subject Heading terms ‘leukoplakia’, ‘neoplasms’, ‘ Candida’, ‘malignant transformation’ and ‘oral’ and included all results until February 2017. The initial search identified 372 articles, which was consolidated to 16 articles after applying inclusion and exclusion criteria. The occurrence of candidal infection in OL ranged from 6.8% to 100.0%. Only 3 of 16 studies reported malignant transformation rates of leukoplakia with Candida infection. The overall malignant transformation rates reported in these studies were 2.5%, 6.5% and 28.7%. This review supports the contention that candidal infection promotes cellular and dysplastic changes in OL. However, further follow-up studies are recommended to confirm the role of Candida infection in malignant transformation of OL lesions.

The association between dietary inflammatory index and risk of central obesity in adults: An updated systematic review and meta-analysis

2020 ◽  
Vol 90 (5-6) ◽  
pp. 535-552 ◽  
Author(s):  
Mahdieh Abbasalizad Farhangi ◽  
Mahdi Vajdi
Keyword(s):  
Systematic Review ◽  
Observational Studies ◽  
Central Obesity ◽  
Assessment Tool ◽  
Weighted Mean Difference ◽  
Meta Analysis ◽  
Dietary Factors ◽  
Cross Sectional ◽  
Inflammatory Status ◽  
Obesity Indices

Abstract. Backgrounds: Central obesity, as a pivotal component of metabolic syndrome is associated with numerous co-morbidities. Dietary factors influence central obesity by increased inflammatory status. However, recent studies didn’t evaluate the association between central obesity and dietary inflammation index (DII®) that give score to dietary factors according to their inflammatory potential. In the current systematic review and meta-analysis, we summarized the studies that investigated the association between DII® with central obesity indices in the general populations. Methods: In a systematic search from PubMed, SCOPUS, Web of Sciences and Cochrane electronic databases, we collected relevant studies written in English and published until 30 October 2019. The population of included studies were apparently healthy subjects or individuals with obesity or obesity-related diseases. Observational studies that evaluated the association between DII® and indices of central obesity including WC or WHR were included. Results: Totally thirty-two studies were included; thirty studies were cross-sectional and two were cohort studies with 103071 participants. Meta-analysis of observational studies showed that higher DII® scores were associated with 1.81 cm increase in WC (Pooled weighted mean difference (WMD) = 1.813; CI: 0.785–2.841; p = 0.001). Also, a non-significant increase in the odds of having higher WC (OR = 1.162; CI: 0.95–1.43; p = 0.154) in the highest DII category was also observed. In subgroup analysis, the continent, dietary assessment tool and gender were the heterogeneity sources. Conclusion: The findings proposed that adherence to diets with high DII® scores was associated with increased WC. Further studies with interventional designs are necessary to elucidate the causality inference between DII® and central obesity indices.

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