scholarly journals Prognostic value of vascular endothelial growth factors A and C in oral squamous cell carcinoma

2014 ◽  
Vol 43 (7) ◽  
pp. 514-520 ◽  
Author(s):  
Mizuki Yanase ◽  
Koroku Kato ◽  
Kunio Yoshizawa ◽  
Natsuyo Noguchi ◽  
Hiroko Kitahara ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factors ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Vascular Endothelial Growth Factors ◽  
Vascular Endothelial ◽  
Endothelial Growth Factors

scholarly journals The prognostic value of immune checkpoints in oral squamous cell carcinoma

Oral Diseases ◽  
2018 ◽  
Vol 25 (6) ◽  
pp. 1435-1445 ◽  
Author(s):  
Meri Sieviläinen ◽  
Rabeia Almahmoudi ◽  
Ahmed Al‐Samadi ◽  
Tuula Salo ◽  
Matti Pirinen ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Immune Checkpoints

scholarly journals Prognostic value of CAIX expression in oral squamous cell carcinoma: a systematic review and meta-analysis

2020 ◽  
Vol 35 (1) ◽  
pp. 1258-1266 ◽  
Author(s):  
Alejandro I. Lorenzo-Pouso ◽  
Mercedes Gallas-Torreira ◽  
Mario Pérez-Sayáns ◽  
Cintia M. Chamorro-Petronacci ◽  
Oscar Alvarez-Calderon ◽  
...  
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Caix Expression

scholarly journals Prognostic value of tertiary lymphoid structure and tumour infiltrating lymphocytes in oral squamous cell carcinoma

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Qunxing Li ◽  
Xiangqi Liu ◽  
Dikan Wang ◽  
Yanqiong Wang ◽  
Huanzi Lu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
T Cells ◽  
Prognostic Factor ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Nk Cells ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Lymphoid Structures ◽  
Infiltrating Lymphocytes

Abstract Tertiary lymphoid structures (TLS) are ectopic lymphoid structures in cancers that are largely associated with favourable prognosis. However, the prognostic value of TLSs in oral squamous cell carcinoma (OSCC) is largely unknown, and the association between tumour infiltrating lymphocytes (TILs) and TLSs has been rarely explored in OSCC. In this study, associated markers of TLS, including peripheral node address (PNAd) in high endothelial venules, CD20 in B cells and CD3 in T cells, were examined in 168 OSCC patients, and survival analysis was performed between TLS-positive and TLS-negative cohorts. We detected the presence of TILs by staining CD8+ cytotoxic T cells and CD57+ NK cells as well. TLSs appeared as highly organized structures in 45 (26.8%) cases. TLS-positive patients had a better 5-year overall survival (OS) rate (88.9% vs. 56.1%, P < 0.001) and relapse-free survival (RFS) rate (88.9% vs. 63.4%, P = 0.002). Moreover, the presence of TLS was an independent prognostic factor for both the 5-year OS rate (hazard ratio [HR] = 3.784; 95% confidence interval [CI], 1.498–9.562) and RFS rate (HR = 3.296; 95% CI, 1.279–8.490) in multivariate analysis. Furthermore, a higher density of CD8+ T cells and CD57+ NK cells was found in TLS-positive sections than in TLS-negative counterparts (P < 0.001), and their combination provided a higher predictive accuracy (AUC = 0.730; 95% CI, 0.654–0.805). In conclusion, our results suggest that TLS is an independent positive prognostic factor for OSCC patients. These findings provide a theoretical basis for the future diagnostic and therapeutic value of TLSs in OSCC treatment.

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