Prevalence of high-risk human papillomavirus type 16 and 18 in oral and cervical cancers in population from Gujarat, West India

2013 ◽  
Vol 43 (4) ◽  
pp. 293-297 ◽  
Author(s):  
Kinjal R. Patel ◽  
Bhairavi N. Vajaria ◽  
Rasheedunnisa Begum ◽  
Ava Desai ◽  
Jayendra B. Patel ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Cervical Cancers ◽  
Human Papillomavirus Type 16

scholarly journals Cervical Cancers Require the Continuous Expression of the Human Papillomavirus Type 16 E7 Oncoprotein Even in the Presence of the Viral E6 Oncoprotein

2012 ◽  
Vol 72 (16) ◽  
pp. 4008-4016 ◽  
Author(s):  
Sean F. Jabbar ◽  
Soyeong Park ◽  
Johannes Schweizer ◽  
Marthe Berard-Bergery ◽  
Henry C. Pitot ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Cervical Cancers ◽  
E7 Oncoprotein ◽  
Human Papillomavirus Type 16 ◽  
E6 Oncoprotein

scholarly journals High-level of viral genomic diversity in cervical cancers: A Brazilian study on human papillomavirus type 16

2015 ◽  
Vol 34 ◽  
pp. 44-51 ◽  
Author(s):  
Cristina Mendes de Oliveira ◽  
Ignacio G. Bravo ◽  
Nathália Caroline Santiago e Souza ◽  
Maria Luiza Nogueira Dias Genta ◽  
José Humberto Tavares Guerreiro Fregnani ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Genomic Diversity ◽  
Cervical Cancers ◽  
Human Papillomavirus Type 16 ◽  
High Level

scholarly journals The High-Risk Human Papillomavirus Type 16 E6 Counters the GAP Function of E6TP1 toward Small Rap G Proteins

2003 ◽  
Vol 77 (2) ◽  
pp. 1614-1620 ◽  
Author(s):  
Latika Singh ◽  
Qingshen Gao ◽  
Ajay Kumar ◽  
Takaya Gotoh ◽  
David E. Wazer ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
G Protein ◽  
Mutational Analysis ◽  
Protein Signaling ◽  
Hpv16 E6 ◽  
Human Papillomavirus Type 16 ◽  
Hpv E6 ◽  
Small G Protein ◽  
Transforming Activity

ABSTRACT We have recently identified E6TP1 (E6-targeted protein 1) as a novel high-risk human papillomavirus type 16 (HPV16) E6-binding protein. Importantly, mutational analysis of E6 revealed a strong correlation between the transforming activity and its abilities to bind and target E6TP1 for ubiquitin-mediated degradation. As a region within E6TP1 has high homology with GAP domains of known and putative Rap GTPase-activating proteins (GAPs), these results raised the possibility that HPV E6 may alter the Rap small-G-protein signaling pathway. Using two different approaches, we now demonstrate that human E6TP1 exhibits GAP activity for Rap1 and Rap2, confirming recent findings that a closely related rat homologue exhibits Rap-specific GAP activity. Using mutational analysis, we localize the GAP activity to residues 240 to 945 of E6TP1. Significantly, we demonstrate that coexpression of HPV16 E6, by promoting the degradation of E6TP1, enhances the GTP loading of Rap. These results support a role of Rap small-G-protein pathway in E6-mediated oncogenesis.

scholarly journals Susceptibility of high-risk human papillomavirus type 16 to clinical disinfectants

2014 ◽  
Vol 69 (6) ◽  
pp. 1546-1550 ◽  
Author(s):  
J. Meyers ◽  
E. Ryndock ◽  
M. J. Conway ◽  
C. Meyers ◽  
R. Robison
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Human Papillomavirus Type 16

scholarly journals Are transforming properties of the bovine papillomavirus E5 protein shared by E5 from high-risk human papillomavirus type 16?

Virology ◽  
2005 ◽  
Vol 332 (1) ◽  
pp. 102-113 ◽  
Author(s):  
Frank A. Suprynowicz ◽  
Gary L. Disbrow ◽  
Vera Simic ◽  
Richard Schlegel
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Bovine Papillomavirus ◽  
Human Papillomavirus Type 16 ◽  
E5 Protein

Presence of human papillomavirus type-16 and type-18 DNA sequences and their expression in cervical cancers and cell lines from japanese patients

1986 ◽  
Vol 37 (4) ◽  
pp. 499-503 ◽  
Author(s):  
Youko Tsunokawa ◽  
Naoko Takebe ◽  
Shiro Nozawa ◽  
Tatsuhiro Kasamatsu ◽  
Lutz Gissmann ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Cell Lines ◽  
Dna Sequences ◽  
Japanese Patients ◽  
Cervical Cancers ◽  
Human Papillomavirus Type 16
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