α-Smooth muscle actin-positive myofibroblasts, in association with epithelial-mesenchymal transition and lymphogenesis, is a critical prognostic parameter in patients with oral tongue squamous cell carcinoma

2013 ◽  
Vol 43 (5) ◽  
pp. 335-343 ◽  
Author(s):  
Lei Ding ◽  
Ziwen Zhang ◽  
Duo Shang ◽  
Jie Cheng ◽  
Hua Yuan ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Smooth Muscle ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Epithelial Mesenchymal Transition ◽  
Smooth Muscle Actin ◽  
Muscle Actin ◽  
Oral Tongue ◽  
Mesenchymal Transition ◽  
Prognostic Parameter

Basaloid Squamous Cell Carcinoma of the Esophagus With or Without Adenoid Cystic Features

2004 ◽  
Vol 128 (10) ◽  
pp. 1124-1130 ◽  
Author(s):  
Tie-Jun Li ◽  
Yong-Xin Zhang ◽  
Julie Wen ◽  
Daniel F. Cowan ◽  
John Hart ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Smooth Muscle ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Squamous Cell ◽  
Smooth Muscle Actin ◽  
Basaloid Squamous Cell Carcinoma ◽  
Muscle Actin ◽  
Adenoid Cystic ◽  
Basaloid Squamous

Abstract Context.—Basaloid squamous cell carcinoma (BSCC) of the esophagus is a rare malignant tumor that morphologically could bear some resemblance to adenoid cystic carcinoma (ACC) originating from salivary glands. Objective.—The purpose of this study is to describe the histologic, immunohistochemical, and ultrastructural findings of BSCCs of the esophagus, with an emphasis on comparing tumors with or without adenoid cystic features. Design.—We reviewed 239 cases of primary esophageal carcinoma and detected 12 cases (5%) of BSCC. The light and electron microscopic findings and immunocytochemical localization of various antigens, including cytokeratins (AE1, AE3), carcinoembryonic antigen, epithelial membrane antigen, S100, smooth muscle actin, and p53, were examined in these BSCC cases. Results.—Histologically, all BSCCs were composed of solid lobules or nests of basaloid cells with well-demarcated outlines surrounded by a fibrous stroma. Seven of 12 tumors showed areas of ACC-like features, that is, cribriform-like pseudoglandular lumina formation and hyaline material surrounding the tumor nests, whereas the remaining 5 tumors were apparently pure basaloid carcinomas. These 2 groups of tumors were histologically and immunohistochemically identical in many aspects, namely, high-grade nuclei of the tumor cells with frequent mitoses, abundant comedo-type necrosis, focal areas of concomitant squamous differentiation, consistent immunoreactivity for cytokeratins, and poor or absent staining for S100 and smooth muscle actin. Ultrastructurally, the basaloid tumor cells exhibited relatively undifferentiated cellular characteristics and undeveloped cell organelles. Conclusion.—Basaloid squamous cell carcinomas of the esophagus frequently have an intimate association with ACC-like patterns, but their histologic, immunocytochemical, and ultrastructural features correspond more to poorly differentiated squamous cell carcinoma than to salivary gland ACC. This distinction is important because genuine ACC is much less aggressive than BSCC.

Stromal Expression of CD34, α-Smooth Muscle Actin and CD26/DPPIV in Squamous Cell Carcinoma of the Skin: A Comparative Immunohistochemical Study

2011 ◽  
Vol 18 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Ayper Kacar ◽  
Ata Türker Arikok ◽  
Tuba Dilay Kokenek Unal ◽  
Evrim Onder ◽  
Sema Hucumenoglu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Smooth Muscle ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Immunohistochemical Study ◽  
Smooth Muscle Actin ◽  
Muscle Actin

scholarly journals Myofibroblasts in Oral submucous fibrosis, Oral squamous cell carcinoma and Normal mucosa- an Immunohistochemical Analysis

2019 ◽  
Author(s):  
Sivachandran Annamalai ◽  
Shaik Mohamed Shamsudeen ◽  
Rooban thavarajah ◽  
Elizabeth jousha ◽  
Uma devi k Rao ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Smooth Muscle ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Smooth Muscle Actin ◽  
Oral Submucous Fibrosis ◽  
Muscle Actin ◽  
Alpha Smooth Muscle Actin ◽  
Submucous Fibrosis

Abstract Background: Myofibroblasts are spindle shaped smooth muscle like fibroblast involved in the physiological repair of tissue structure can also cause pathological remodeling of tissue by forming fibrosis. They express smooth muscle actin which can be evaluated for their biological behavior in the physiological and pathological conditions. Aim: To evaluate the expression of Myofibroblasts in oral submucous fibrosis, oral squamous cell carcinoma and normal mucosa by Immunohistochemical analysis. Methods: It is a cross-sectional study done to evaluate the expression of Myofibroblasts in oral submucous fibrosis (Group-1), oral squamous cell carcinoma (Group-2) and normal buccal mucosa (Group-3) using immunohistochemistry using alpha smooth muscle actin in formalin fixed, paraffin embedded tissue specimens. The localization of stain, nature of stain, intensity of stain and the percentage of cells stained among the three groups were studied and compared. Results: The gender distributions in the study were in favor of males. It was observed that Staining Intensity was seen more in group I (30%) than in group II (20%) and progressively increased from early (16.5%) to advance stage(50%) of oral submucous fibrosis. Higher staining intensity was observed in well differentiated oral squamous cell carcinoma. Conclusion: Myofibroblasts are important in normal healing process, but can induce fibrosis. In oral submucous fibrosis, they can be used to assess the severity of the lesion by their increased expression of alpha smooth muscle actin. In oral carcinogenesis increase in the number of alpha smooth muscle actin can change the distribution pattern results in tumor invasive characteristics. Key Words: Myofibroblasts, Alpha smooth muscle actin, Staining intensity, Oral Submucous Fibrosis, Oral Squamous Cell Carcinoma.

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