Predicting Prodromal Alzheimer's Disease in Subjects with Mild Cognitive Impairment Using Machine Learning Classification of Multimodal Multicenter Diffusion-Tensor and Magnetic Resonance Imaging Data

2015 ◽  
Vol 25 (5) ◽  
pp. 738-747 ◽  
Author(s):  
Martin Dyrba ◽  
Frederik Barkhof ◽  
Andreas Fellgiebel ◽  
Massimo Filippi ◽  
Lucrezia Hausner ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Machine Learning ◽  
Cognitive Impairment ◽  
Diffusion Tensor ◽  
Imaging Data ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Data ◽  
Machine Learning Classification ◽  
Prodromal Alzheimer’S Disease

scholarly journals An overview of the quality assurance and quality control of magnetic resonance imaging data for the Ontario Neurodegenerative Disease Research Initiative (ONDRI): pipeline development and neuroinformatics

2020 ◽  
Author(s):  
Christopher J.M. Scott ◽  
Stephen R. Arnott ◽  
Aditi Chemparathy ◽  
Fan Dong ◽  
Igor Solovey ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cognitive Impairment ◽  
Magnetic Resonance ◽  
Image Quality ◽  
Neurodegenerative Disease ◽  
Imaging Data ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Data ◽  
Disease Research ◽  
Research Initiative

ABSTRACTLarge scale research studies combining magnetic resonance imaging data generated at multiple sites on multiple vendor platforms are becoming more commonplace. The Ontario Neurodegenerative Disease Research Initiative (ONDRI - http://ondri.ca/), a project funded by the Ontario Brain Institute (OBI), is a recently established province-wide natural history study, which has recruited more than 500 participants from neurodegenerative disease groups including amyotrophic lateral sclerosis, fronto-temporal dementia, Parkinson’s disease, Alzheimer’s disease, mild cognitive impairment, and cerebrovascular disease (previously referred to as the vascular cognitive impairment cohort). Because of its multi-site nature, all captured data must be standardized and meet minimum quality standards to reduce variability. The goal of the ONDRI imaging platform is to maximize data quality by implementing vendor-specific harmonized MR imaging protocols (consistent with the Canadi-an Dementia Imaging Protocol - http://www.cdip-pcid.ca/), monitoring protocol adherence, qualitatively assessing image quality, measuring signal-to-noise and contrast-to-noise, monitoring system stability, and applying corrections based on the analysis of images from two different phantoms regularly acquired at each site. To maximize image quality, this work describes the use of various automatic pipelines and manual assessment steps, integrated within an established informatics and databasing platform, the Stroke Patient Recovery Research Database (SPReD) built on the Extensible Neuroimaging Archive Toolkit (XNAT), and contained within the Brain-CODE (Centre for Ontario Data Exploration) framework. The purpose of the current paper is to describe the steps undertaken by ONDRI to achieve this high standard of data integrity. Data have been successfully collected for the past 4 years with the pipelines and assessments identifying deviations, allowing for timely interventions and assessment of image quality.

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