Impact of Apolipoprotein E4 Polymorphism on the Gray Matter Volume and the White Matter Integrity in Subjective Memory Impairment without White Matter Hyperintensities: Voxel-Based Morphometry and Tract-Based Spatial Statistics Study under 3-Tesla MRI

2015 ◽  
Vol 26 (1) ◽  
pp. 144-149 ◽  
Author(s):  
Young-Min Lee ◽  
Ji-Kyung Ha ◽  
Je-Min Park ◽  
Byung-Dae Lee ◽  
EunSoo Moon ◽  
...  
Keyword(s):  
White Matter ◽  
Memory Impairment ◽  
White Matter Hyperintensities ◽  
Gray Matter Volume ◽  
White Matter Integrity ◽  
Voxel Based Morphometry ◽  
Subjective Memory ◽  
Matter Volume ◽  
Subjective Memory Impairment ◽  
3 Tesla Mri

scholarly journals Topographic patterns of white matter hyperintensities are associated with multimodal neuroimaging biomarkers of Alzheimer’s disease

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Malo Gaubert ◽  
Catharina Lange ◽  
Antoine Garnier-Crussard ◽  
Theresa Köbe ◽  
Salma Bougacha ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Glucose Metabolism ◽  
Corpus Callosum ◽  
Gray Matter ◽  
Fdg Pet ◽  
White Matter Hyperintensities ◽  
Gray Matter Volume ◽  
Matter Volume

Abstract Background White matter hyperintensities (WMH) are frequently found in Alzheimer’s disease (AD). Commonly considered as a marker of cerebrovascular disease, regional WMH may be related to pathological hallmarks of AD, including beta-amyloid (Aβ) plaques and neurodegeneration. The aim of this study was to examine the regional distribution of WMH associated with Aβ burden, glucose hypometabolism, and gray matter volume reduction. Methods In a total of 155 participants (IMAP+ cohort) across the cognitive continuum from normal cognition to AD dementia, FLAIR MRI, AV45-PET, FDG-PET, and T1 MRI were acquired. WMH were automatically segmented from FLAIR images. Mean levels of neocortical Aβ deposition (AV45-PET), temporo-parietal glucose metabolism (FDG-PET), and medial-temporal gray matter volume (GMV) were extracted from processed images using established AD meta-signature templates. Associations between AD brain biomarkers and WMH, as assessed in region-of-interest and voxel-wise, were examined, adjusting for age, sex, education, and systolic blood pressure. Results There were no significant associations between global Aβ burden and region-specific WMH. Voxel-wise WMH in the splenium of the corpus callosum correlated with greater Aβ deposition at a more liberal threshold. Region- and voxel-based WMH in the posterior corpus callosum, along with parietal, occipital, and frontal areas, were associated with lower temporo-parietal glucose metabolism. Similarly, lower medial-temporal GMV correlated with WMH in the posterior corpus callosum in addition to parietal, occipital, and fontal areas. Conclusions This study demonstrates that local white matter damage is correlated with multimodal brain biomarkers of AD. Our results highlight modality-specific topographic patterns of WMH, which converged in the posterior white matter. Overall, these cross-sectional findings corroborate associations of regional WMH with AD-typical Aß deposition and neurodegeneration.

Correlation between degree of white matter hyperintensities and global gray matter volume decline rate

2010 ◽  
Vol 53 (6) ◽  
pp. 397-403 ◽  
Author(s):  
Yasuyuki Taki ◽  
Shigeo Kinomura ◽  
Kazunori Sato ◽  
Ryoi Goto ◽  
Kai Wu ◽  
...  
Keyword(s):  
White Matter ◽  
Gray Matter ◽  
White Matter Hyperintensities ◽  
Gray Matter Volume ◽  
Matter Volume ◽  
Decline Rate

scholarly journals Altered Gray Matter Volume and White Matter Integrity in College Students with Mobile Phone Dependence

2016 ◽  
Vol 7 ◽  
Author(s):  
Yongming Wang ◽  
Zhiling Zou ◽  
Hongwen Song ◽  
Xiaodan Xu ◽  
Huijun Wang ◽  
...  
Keyword(s):  
College Students ◽  
White Matter ◽  
Mobile Phone ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
White Matter Integrity ◽  
Matter Volume

scholarly journals MRI Markers for Mild Cognitive Impairment: Comparisons between White Matter Integrity and Gray Matter Volume Measurements

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e66367 ◽  
Author(s):  
Yu Zhang ◽  
Norbert Schuff ◽  
Monica Camacho ◽  
Linda L. Chao ◽  
Thomas P. Fletcher ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
White Matter Integrity ◽  
Matter Volume ◽  
Volume Measurements

Disrupted White Matter Networks from Subjective Memory Impairment to Amnestic Mild Cognitive Impairment

2021 ◽  
Vol 18 (1) ◽  
pp. 35-44
Author(s):  
Wen Shao ◽  
Xuwen He ◽  
Xin Li ◽  
Wuhai Tao ◽  
Junying Zhang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Memory Impairment ◽  
Diffusion Tensor ◽  
Amnestic Mild Cognitive Impairment ◽  
Subjective Memory ◽  
Subjective Memory Impairment ◽  
Parietal Lobes ◽  
Network Disruptions

Background and Objective: Subjective memory impairment (SMI) is a preclinical stage prior to amnestic mild cognitive impairment (aMCI) along with the Alzheimer’s disease (AD) continuum. We hypothesized that SMI patients had white matter (WM) network disruptions similar to those in aMCI patients. Methods: We used diffusion-tensor magnetic resonance imaging and graph theory to construct, analyze, and compare the WM networks among 20 normal controls (NC), 20 SMI patients, and 20 aMCI patients. Results: Compared with the NC group, the SMI group had significantly decreased global and local efficiency and an increased shortest path length. Moreover, similar to the aMCI group, the SMI group had lower nodal efficiency in regions located in the frontal and parietal lobes, limbic systems, and caudate nucleus compared to that of the NC group. Conclusion: Similar to aMCI patient, SMI patients exhibited WM network disruptions, and detection of these disruptions could facilitate the early detection of SMI.

Association of regional gray matter volume loss and progression of white matter lesions in multiple sclerosis — A longitudinal voxel-based morphometry study

NeuroImage ◽  
2009 ◽  
Vol 45 (1) ◽  
pp. 60-67 ◽  
Author(s):  
Kerstin Bendfeldt ◽  
Pascal Kuster ◽  
Stefan Traud ◽  
Hanspeter Egger ◽  
Sebastian Winklhofer ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
White Matter Lesions ◽  
Volume Loss ◽  
Voxel Based Morphometry ◽  
Matter Volume

Cognitive impairment in MS: Impact of white matter integrity, gray matter volume, and lesions

Neurology ◽  
2013 ◽  
Vol 80 (11) ◽  
pp. 1025-1032 ◽  
Author(s):  
H. E. Hulst ◽  
M. D. Steenwijk ◽  
A. Versteeg ◽  
P. J. W. Pouwels ◽  
H. Vrenken ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
White Matter Integrity ◽  
Matter Volume
Sign in / Sign up

Export Citation Format

Share Document