Susceptibility-Weighted Phase Imaging and Oxygen Extraction Fraction Measurement during Sedation and Sedation Recovery using 7T MRI

2014 ◽  
Vol 25 (4) ◽  
pp. 575-581 ◽  
Author(s):  
Jonathan A. Goodwin ◽  
Kohsuke Kudo ◽  
Yutaka Shinohe ◽  
Satomi Higuchi ◽  
Ikuko Uwano ◽  
...  
Keyword(s):  
Oxygen Extraction Fraction ◽  
Oxygen Extraction ◽  
Phase Imaging ◽  
Extraction Fraction ◽  
Fraction Measurement

Validation of T 2 ‐based oxygen extraction fraction measurement with 15 O positron emission tomography

2020 ◽  
Vol 85 (1) ◽  
pp. 290-297
Author(s):  
Dengrong Jiang ◽  
Shengwen Deng ◽  
Crystal G. Franklin ◽  
Michael O'Boyle ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Emission Tomography ◽  
Oxygen Extraction Fraction ◽  
Oxygen Extraction ◽  
Extraction Fraction ◽  
Positron Emission ◽  
Fraction Measurement

scholarly journals Validation of oxygen extraction fraction measurement by qBOLD technique

2008 ◽  
Vol 60 (4) ◽  
pp. 882-888 ◽  
Author(s):  
Xiang He ◽  
Mingming Zhu ◽  
Dmitriy A. Yablonskiy
Keyword(s):  
Oxygen Extraction Fraction ◽  
Oxygen Extraction ◽  
Extraction Fraction ◽  
Fraction Measurement

scholarly journals Mapping of Cerebral Oxygen Extraction Fraction Changes with Susceptibility-weighted Phase Imaging

Radiology ◽  
2011 ◽  
Vol 261 (3) ◽  
pp. 930-936 ◽  
Author(s):  
Yuri Zaitsu ◽  
Kohsuke Kudo ◽  
Satoshi Terae ◽  
Rie Yazu ◽  
Kinya Ishizaka ◽  
...  
Keyword(s):  
Oxygen Extraction Fraction ◽  
Oxygen Extraction ◽  
Phase Imaging ◽  
Cerebral Oxygen ◽  
Extraction Fraction

scholarly journals Oxygen Extraction Fraction at Maximally Vasodilated Tissue in the Ischemic Brain Estimated from the Regional CO2 Responsiveness Measured by Positron Emission Tomography

1988 ◽  
Vol 8 (2) ◽  
pp. 227-235 ◽  
Author(s):  
Iwao Kanno ◽  
Kazuo Uemura ◽  
Schuichi Higano ◽  
Matsutaro Murakami ◽  
Hidehiro Iida ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Resting State ◽  
Emission Tomography ◽  
Oxygen Extraction Fraction ◽  
Oxygen Extraction ◽  
Cross Point ◽  
Steady State Method ◽  
Extraction Fraction ◽  
Positron Emission ◽  
Vascular Responsiveness

The oxygen extraction fraction (OEF) at maximally vasodilated tissue in patients with chronic cerebrovascular disease was evaluated using positron emission tomography. The vascular responsiveness to changes in PaCO2 was measured by the H215O autoradiographic method. It was correlated with the resting-state OEF, as estimated using the 15O steady-state method. The subjects comprised 15 patients with unilateral or bilateral occlusion and stenosis of the internal carotid artery or middle cerebral artery or moyamoya disease. In hypercapnia, the scattergram between the OEF and the vascular responsiveness to changes in PaCO2 revealed a significant negative correlation in 11 of 19 studies on these patients, and the OEF at the zero cross point of the regression line with a vascular responsiveness of 0 was 0.53 ± 0.08 (n = 11). This OEF in the resting state corresponds to exhaustion of the capacity for vasodilation. The vasodilatory capacity is discussed in relation to the lower limit of autoregulation.

scholarly journals Quantifying the changes in oxygen extraction fraction and cerebral activity caused by caffeine and acetazolamide

2016 ◽  
Vol 37 (3) ◽  
pp. 825-836 ◽  
Author(s):  
Sagar Buch ◽  
Yongquan Ye ◽  
E Mark Haacke
Keyword(s):  
Oxygen Saturation ◽  
A Priori ◽  
Susceptibility Mapping ◽  
Oxygen Extraction Fraction ◽  
Oxygen Extraction ◽  
Cerebral Veins ◽  
Blood Oxygen Saturation ◽  
Vascular Reserve ◽  
Extraction Fraction ◽  
Before And After

A quantitative estimate of cerebral blood oxygen saturation is of critical importance in the investigation of cerebrovascular disease. We aimed to measure the change in venous oxygen saturation (Yv) before and after the intake of the vaso-dynamic agents caffeine and acetazolamide with high spatial resolution using susceptibility mapping. Caffeine and acetazolamide were administered on separate days to five healthy volunteers to measure the change in oxygen extraction fraction. The internal streaking artifacts in the susceptibility maps were reduced by giving an initial susceptibility value uniformly to the structure-of-interest, based on a priori information. Using this technique, Yv for normal physiological conditions, post-caffeine and post-acetazolamide was measured inside the internal cerebral veins as YNormal = 69.1 ± 3.3%, YCaffeine = 60.5 ± 2.8%, and YAcet = 79.1 ± 4.0%. This suggests that susceptibility mapping can serve as a sensitive biomarker for measuring reductions in cerebro-vascular reserve through abnormal vascular response. The percentage change in oxygen extraction fraction for caffeine and acetazolamide were found to be +27.0 ± 3.8% and −32.6 ± 2.1%, respectively. Similarly, the relative changes in cerebral blood flow in the presence of caffeine and acetazolamide were found to be −30.3% and + 31.5%, suggesting that the cerebral metabolic rate of oxygen remains stable between normal and challenged brain states for healthy subjects.

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