Optic Neuritis and the Visual Pathway: Evaluation of Neuromyelitis Optica Spectrum by Resting-State fMRI and Diffusion Tensor MRI

2015 ◽  
Vol 25 (5) ◽  
pp. 807-812 ◽  
Author(s):  
Fernanda Cristina Rueda Lopes ◽  
Soniza Vieira Alves-Leon ◽  
Jose Mauricio Godoy ◽  
Simone de Souza Batista Scherpenhuijzen ◽  
Leticia Fezer ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Neuromyelitis Optica ◽  
Resting State ◽  
Diffusion Tensor ◽  
Resting State Fmri ◽  
Visual Pathway ◽  
Diffusion Tensor Mri ◽  
And Diffusion

Bidirectional degeneration in the visual pathway in neuromyelitis optica spectrum disorder (NMOSD)

2017 ◽  
Vol 24 (12) ◽  
pp. 1585-1593 ◽  
Author(s):  
De-Cai Tian ◽  
Lei Su ◽  
Moli Fan ◽  
Jian Yang ◽  
Rui Zhang ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Neuromyelitis Optica ◽  
Diffusion Tensor ◽  
Retinal Thickness ◽  
Three Dimensional ◽  
Visual Pathway ◽  
Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Fiber Layer ◽  
Optic Radiations

Objective: This study aims to investigate whether bidirectional degeneration occurs within the visual pathway and, if so, the extent of such changes in neuromyelitis optica spectrum disorder (NMOSD). Methods: In total, 36 NMOSD and 24 healthy controls (HCs) were enrolled. Three-dimensional T1-weighted magnetic resonance imaging (MRI) and diffusion tensor imaging were used to analyze damage to the posterior visual pathway. Damage to the anterior visual pathway was measured by optical coherence tomography. Results: In total, 24 NMOSD with prior optic neuritis (NMOON) patients showed significant reduction of peripapillary retinal nerve fiber layer, inner and outer retinal thickness, lateral geniculate nucleus volume, primary visual cortex volume, and decreased integrity of optic radiations, compared with 12 NMOSD without prior optic neuritis (NMONON) patients and 24 HCs. In NMONON, only the inner retinal thickness and the integrity of optic radiations were significantly reduced in comparison with HCs. Moreover, patients with optic neuritis showed severe bidirectional degeneration, the loss of the RNFL was greater than the atrophy of V1. Conclusion: Our study indicated the presence of trans-synaptic degeneration in NMOSD. Damage to the inner retina and optic radiations can be observed even in NMONON. After an episode of optic neuritis, the anterior visual pathway damage is greater than the posterior visual pathway damage.

Magnetization transfer and diffusion tensor MRI show gray matter damage in neuromyelitis optica

Neurology ◽  
2004 ◽  
Vol 62 (3) ◽  
pp. 476-478 ◽  
Author(s):  
M. A. Rocca ◽  
F. Agosta ◽  
D. M. Mezzapesa ◽  
V. Martinelli ◽  
F. Salvi ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Gray Matter ◽  
Diffusion Tensor ◽  
Magnetization Transfer ◽  
Diffusion Tensor Mri ◽  
And Diffusion

Structural brain abnormalities are related to retinal nerve fiber layer thinning and disease duration in neuromyelitis optica spectrum disorders

2014 ◽  
Vol 20 (9) ◽  
pp. 1189-1197 ◽  
Author(s):  
Felipe von Glehn ◽  
Sven Jarius ◽  
Rodrigo Pessoa Cavalcanti Lira ◽  
Maria Carolina Alves Ferreira ◽  
Fadua H Ribeiro von Glehn ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Neuromyelitis Optica ◽  
Retinal Nerve Fiber Layer ◽  
Disease Duration ◽  
Diffusion Tensor ◽  
Brain Abnormalities ◽  
Fiber Layer ◽  
Spectrum Disorders ◽  
And Diffusion ◽  
Structural Brain

Background: Although aquaporin-4 (AQP4) is widely expressed in the human brain cortex, lesions are rare in neuromyelitis optica (NMO) spectrum disorders (NMOSD). Recently, however, several studies have demonstrated occult structural brain atrophy in NMO. Objective: This study aims to investigate magnetic resonance imaging (MRI) patterns of gray matter (GM) and white matter (WM) abnormalities in patients with NMOSD and to assess the visual pathway integrity during disease duration correlation of the retinal nerve fiber layer (RNFL) and pericalcarine cortex thickness. Methods: Twenty-one patients with NMOSD and 34 matched healthy controls underwent both high-field MRI (3T) high-resolution T1-weighted and diffusion-tensor MRI. Voxel-based morphometry, cortical analyses (Freesurfer) and diffusion-tensor imaging (DTI) analyses (TBSS-FSL) were used to investigate brain abnormalities. In addition, RNFL measurement by optic-coherence tomography (OCT) was performed. Results: We demonstrate that NMOSD is associated with GM and WM atrophy, encompassing more frequently the motor, sensory and visual pathways, and that the extent of GM atrophy correlates with disease duration. Furthermore, we demonstrate for the first time a correlation between RNFL and pericalcarine cortical thickness, with cortical atrophy evolving over the course of disease. Conclusions: Our findings indicate a role for retrograde and anterograde neurodegeneration in GM atrophy in NMOSD. However, the presence atrophy encompassing almost all lobes suggests that additional pathomechanisms might also be involved.

scholarly journals Whole-Brain Functional and Diffusion Tensor MRI in Human Participants with Metallic Orthodontic Braces

Radiology ◽  
2020 ◽  
Vol 294 (1) ◽  
pp. 149-157 ◽  
Author(s):  
Xinyuan Miao ◽  
Yuankui Wu ◽  
Dapeng Liu ◽  
Hangyi Jiang ◽  
David Woods ◽  
...  
Keyword(s):  
Diffusion Tensor ◽  
Diffusion Tensor Mri ◽  
Whole Brain ◽  
Human Participants ◽  
And Diffusion

Effects of handedness and gender on macro- and microstructure of the corpus callosum and its subregions: a combined high-resolution and diffusion-tensor MRI study

2004 ◽  
Vol 21 (3) ◽  
pp. 418-426 ◽  
Author(s):  
René Westerhausen ◽  
Frank Kreuder ◽  
Sarah Dos Santos Sequeira ◽  
Christof Walter ◽  
Wolfgang Woerner ◽  
...  
Keyword(s):  
High Resolution ◽  
Corpus Callosum ◽  
Diffusion Tensor ◽  
Diffusion Tensor Mri ◽  
And Gender ◽  
Mri Study ◽  
And Diffusion

Abnormal Brain Functions in Neuromyelitis Optica: a Resting-state fMRI Study

NeuroImage ◽  
2009 ◽  
Vol 47 ◽  
pp. S90
Author(s):  
Q-Z Wu ◽  
D-D Zhao ◽  
D He ◽  
X-Q Huang ◽  
T-J Zhang ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Resting State ◽  
Resting State Fmri ◽  
Brain Functions ◽  
Fmri Study ◽  
Abnormal Brain

Upper motor neuron involvement in amyotrophic lateral sclerosis evaluated by triple stimulation technique and diffusion tensor MRI

2013 ◽  
Vol 260 (6) ◽  
pp. 1535-1544 ◽  
Author(s):  
Jasna Furtula ◽  
Birger Johnsen ◽  
Jesper Frandsen ◽  
Anders Rodell ◽  
Peter Broegger Christensen ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Motor Neuron ◽  
Diffusion Tensor ◽  
Diffusion Tensor Mri ◽  
And Diffusion ◽  
Stimulation Technique ◽  
Lateral Sclerosis ◽  
Triple Stimulation Technique
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