scholarly journals Dual versus single long‐acting bronchodilator use could raise acute coronary syndrome risk by over 50%: A population‐based nested case–control study

2021 ◽  
Author(s):  
Lianne Parkin ◽  
Sheila Williams ◽  
Katrina Sharples ◽  
David Barson ◽  
Simon Horsburgh ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Coronary Syndrome ◽  
Dual Versus ◽  
Long Acting ◽  
Nested Case Control ◽  
Control Study

Risk of acute coronary syndrome in elderly users of antipsychotic drugs: a nested case-control study

Heart ◽  
2012 ◽  
Vol 98 (15) ◽  
pp. 1166-1171 ◽  
Author(s):  
Bart C Kleijer ◽  
Huiberdina L Koek ◽  
Rob J van Marum ◽  
Paul A F Jansen ◽  
Toine C G Egberts ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Antipsychotic Drugs ◽  
Case Control Study ◽  
Case Control ◽  
Coronary Syndrome ◽  
Nested Case Control ◽  
Elderly Users ◽  
Control Study

scholarly journals Urinary flavonoid excretion and risk of acute coronary syndrome in a nested case-control study

2013 ◽  
Vol 98 (1) ◽  
pp. 209-216 ◽  
Author(s):  
Lea Bredsdorff ◽  
Tina Obel ◽  
Claus Dethlefsen ◽  
Anne Tjønneland ◽  
Erik B Schmidt ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Case Control Study ◽  
Case Control ◽  
Coronary Syndrome ◽  
Nested Case Control ◽  
Control Study

scholarly journals Evaluating the Role of Perceived Stress on the Likelihood of Having a Non - Fatal Acute Coronary Syndrome: A Case-Control Study

2014 ◽  
Vol 8 (1) ◽  
pp. 68-75 ◽  
Author(s):  
Alexia Katsarou ◽  
Filippos Triposkiadis ◽  
John Skoularigis ◽  
Emmanuela Griva ◽  
George Neroutsos ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Perceived Stress ◽  
Case Control Study ◽  
Rating Scale ◽  
Early Recognition ◽  
Population Based ◽  
Case Control ◽  
Coronary Syndrome ◽  
Control Study

Objectives: The aim of the current study was to evaluate the independent role of perceived stress, measured by the PSS-14, on the likelihood of having acute coronary syndrome (ACS). Conclusion: This is a case-control study with individual matching by age and sex. During 2010-2012, 250 consecutive patients (60±11 years, 78% men) with a first ACS and 250 population-based, control subjects (60±8.6 years, 77.6% men), were enrolled. Perceived stress levels were evaluated with the PSS-14 scale, depression status was assessed with the Zung Depression Rating Scale, anxiety status with the STAI scale and adherence to the Mediterranean diet was assessed by the MedDietScore. Conclusion: Higher perceived stress was associated with increased likelihood of having an ACS, after adjusting for various factors (OR=1.15, %CI 1.11, 1.18). STAI and ZUNG scale were positively associated with the likelihood of having an ACS (OR: 1.27 %CI 1.20-1.34, p<0.001 and OR: 1.49 %CI 1.36-1.63, p<0.001 respectively). Stratified analysis by sex showed a greater impact of perceived stress in men, compared with women (Wald test value 45.65 vs 18.56, respectively). When stratifying by depression levels, the effect of perceived stress on ACS was not significant among depressed individuals. When stratifying by level of anxiety, higher odds of having an ACS was found in the low anxiety group (OR: 1.129, %CI 1.047-1.218). Conclusion: Perceived stress appears as an independent ACS risk factor, although no causal relationship can be extracted due to the nature of the study. Early recognition and treatment of perceived stress may lead to ACS risk reduction.

scholarly journals The relationship between epigenetic age and myocardial infarction/acute coronary syndrome and in a population based nested case-control study

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
S Malyutina ◽  
O Chervova ◽  
T Tillmann ◽  
V Maximov ◽  
A Ryabikov ◽  
...  
Keyword(s):  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Chronological Age ◽  
Metabolic Factors ◽  
Coronary Syndrome ◽  
Epigenetic Age ◽  
Nested Case Control ◽  
The Relationship ◽  
Control Study

Abstract Background The measure of “epigenetic age” (EA) derived from DNA methylation (DNAm) is considered as biomarker of ageing. Objective We investigated the relationship between EA and Myocardial Infarction (MI) /Acute coronary syndrome (ACS) in a nested case-control study of the elderly population. Methods A random population sample was examined at baseline (2003/05, n=9360, age 45–69, the Russian arm of the HAPIEE Project), re-examined in 2006/08, 2015/17, and followed up for an average 15 years for fatal and non-fatal events. Using a nested case-control study design, we selected participants with incident MI/ACS (cases) and age-and sex-stratified controls among those free from baseline CVD. We performed DNAm profiling of the whole blood samples (using Illumina EPIC arrays) collected at baseline. After quality control, 135 cases and 185 controls were included in the analysis. Baseline EA was calculated using Horvath, Hannum, PhenoAge and Skin and Blood DNAm clocks; the differences between EA and chronological age (CA) were denoted as DAHr, DAHn, DAPh, DASB, respectively. Results DNAm ages calculated with Horvath's, Hannum's and Skin and Blood clocks were close to the CA; the corresponding median absolute differences (MAD) were 3.38, 3.64 and 2.79 years, and mean (SD) −0.85 (5.37), 1.96 (5.18) and 2.10 (3.94) for DAHr, DAHn and DASB respectively. As expected, PhenoAge's predictions were less precise with MAD=9.41 and DAPh mean (SD) 8.94 (6.38). The mean DAHr and DAHn were significantly higher in MI/ACS compared to controls (0.99 (5.38) vs. −1.55 (5.27), p=0.007, and 2.89 (6.37) vs. 1.28 (4.95), p=0.006 correspondingly), DASB was borderline higher in MI/ACS vs controls and DAPh was similar in cases and controls. After controlling for sex, the risk of MI/ACS was higher in DAHr terciles 2 and 3 vs. tercile 1 (OR=1.08 [95% CI 0.61–1.89], p=0.799 and OR=2.09 [1.19–3.66], p=0.010); the association was independent of smoking but it was largely explained (or mediated) by metabolic factors (blood pressure, body mass index, total and LDL-cholesterol). Similarly, the risk of MI/ACS was increased in terciles 2 and 3 of DAHn; compared with lowest tercile, the OR were 1.52 [0.86–2.71], p=0.152 and 2.41 [1.34–4.34], p=0.003), respectively; again, the association was largely explained by metabolic factors. There was no association found between baseline DAPh or DASB and the risk of MI/ACS. Conclusion In this case-control study nested in a prospective population-based cohort, we found an association between acceleration of epigenetic age and increased risk of MI/ACS independent of sex and smoking. The risk of MI/ACS was about 2-fold higher in the top tercile of difference between epigenetic and chronological age. The excess risk is appeared to be modulated by metabolic factors. FUNDunding Acknowledgement Type of funding sources: Foundation. Main funding source(s): Russian Science Foundation; Russian Academy of Sciences, Sate Assignment

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