scholarly journals Haemodynamics of primary aldosteronism associated with adrenocortical adenoma: insights from bioimpedance cardiography measurements

2020 ◽  
Vol 289 (1) ◽  
pp. 134-136
Author(s):  
G. Mulè ◽  
G. Geraci ◽  
C. Carollo ◽  
S. Cottone
Keyword(s):  
Primary Aldosteronism ◽  
Adrenocortical Adenoma ◽  
Bioimpedance Cardiography

scholarly journals Primary Aldosteronism Associated with Multiple Adrenocortical Micronodules in a Patient with Renal Cell Carcinoma

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Kazuhito Oba ◽  
Yuko Chiba ◽  
Yoko Matsuda ◽  
Takeshi Kumakawa ◽  
Rie Aoyama ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Primary Aldosteronism ◽  
Renal Cell ◽  
Zona Glomerulosa ◽  
Adrenocortical Adenoma ◽  
Loading Test ◽  
Cell Renal Cell Carcinoma ◽  
Aldosterone To Renin Ratio ◽  
The Right

A 47-year-old woman with a history of diabetes mellitus (DM) and obesity was admitted to our hospital for glucose control. She was detected to have hypertension (HT) and diagnosed with primary aldosteronism (PA) based on the high level of aldosterone to renin ratio and the results of the upright furosemide-loading test according to the criteria of the Japanese Society of Hypertension (JSH) guidelines. Computed tomography revealed left renal tumor and adrenocortical adenoma. She underwent left nephrectomy and adrenalectomy. The pathological findings were clear-cell renal cell carcinoma (RCC) and nonfunctional adrenocortical adenoma. Her nonneoplastic adrenal tissue histologically revealed CYP11B2-positive multiple adrenocortical micronodules (MNs) and concomitant paradoxical hyperplasia of the zona glomerulosa. Therefore, MNs were thought to be responsible for PA in this patient. After surgery, HT was improved, and the result of upright furosemide-loading test after 12 months of surgery did not fulfill the criteria of PA according to the JSH guidelines. However, the adrenocorticotrophic hormone stimulation test was positive; considering the possibility of slight aldosterone overproduction from the right adrenal gland, the administration of spironolactone was started. Herein, we report a rare case of RCC in conjunction with PA histologically associated with MNs.

ACTH-Dependent Aldosterone Excess Due to Adrenocortical Adenoma: A Variant of Primary Aldosteronism

1978 ◽  
Vol 46 (2) ◽  
pp. 326-335 ◽  
Author(s):  
G.J. WENTING ◽  
A.J. MAN IN'T VELD ◽  
F. H. DERKX ◽  
P. V. BRUMMELEN ◽  
M. A. D. H. SCHALEKAMP
Keyword(s):  
Primary Aldosteronism ◽  
Adrenocortical Adenoma

Heterotopic Adrenocortical Adenoma Producing Primary Aldosteronism

1967 ◽  
Vol 98 (2) ◽  
pp. 133-139 ◽  
Author(s):  
Malachi J. Flanagan ◽  
James H. Mcdonald
Keyword(s):  
Primary Aldosteronism ◽  
Adrenocortical Adenoma

scholarly journals Cushing’s Syndrome by Left Adrenocortical Adenoma Synchronously Associated with Primary Aldosteronism by Right Adrenocortical Adenoma: Report of a Case

2009 ◽  
Vol 56 (3) ◽  
pp. 495-502 ◽  
Author(s):  
Naoyoshi ONODA ◽  
Tetsuro ISHIKAWA ◽  
Kohei NISHIO ◽  
Hideki TAHARA ◽  
Masaaki INABA ◽  
...  
Keyword(s):  
Cushing’S Syndrome ◽  
Primary Aldosteronism ◽  
Cushing's Syndrome ◽  
Adrenocortical Adenoma

scholarly journals In Silico Analysis of the Gene Expression Patterns between Aldosterone-Producing Adenoma and Nonfunctional Adrenocortical Adenoma

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Yongfa Dai ◽  
Jing Li ◽  
Hong Wen ◽  
Jie Liu ◽  
Jianling Li
Keyword(s):  
Gene Expression ◽  
Expression Pattern ◽  
Primary Aldosteronism ◽  
Expression Patterns ◽  
Gene Expression Pattern ◽  
Gene Expression Patterns ◽  
Pathophysiological Mechanism ◽  
Adrenocortical Adenoma ◽  
Hub Genes ◽  
Aldosterone Producing Adenoma

Primary aldosteronism is the most common form of secondary hypertension, and aldosteronoma makes up a significant proportion of primary aldosteronism cases. Aldosteronoma is also called aldosterone-producing adenoma (APA). Although there have been many studies about APA, the pathogenesis of this disease is not yet fully understood. In this study, we aimed to find out the difference of gene expression patterns between APA and nonfunctional adrenocortical adenoma (NFAA) using a weighted gene coexpression network (WGCNA) and differentially expressed gene (DEG) analysis; only the genes that meet the corresponding standards of both methods were defined as real hub genes and then used for further analysis. Twenty-nine real hub genes were found out, most of which were enriched in the phospholipid metabolic process. WISP2, S100A10, SSTR5-AS1, SLC29A1, APOC1, and SLITRK4 are six real hub genes with the same gene expression pattern between the combined and validation datasets, three of which indirectly or directly participate in lipid metabolism including WISP2, S100A10, and APOC1. According to the gene expression pattern of DEGs, we speculated five candidate drugs with potential therapeutic value for APA, one of which is cycloheximide, an inhibitor for phospholipid biosynthesis. All the evidence suggests that phospholipid metabolism may be an important pathophysiological mechanism for APA. Our study provides a new perspective regarding the pathophysiological mechanism of APA and offers some small molecules that may possibly be effective drugs against APA.

scholarly journals Pearls & Oy-sters: Cerebral Microbleeds Caused by Adrenocortical Adenoma-related Primary Aldosteronism

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000011934
Author(s):  
Sun Min Lee ◽  
Yong Jun Choi ◽  
Kihwang Lee ◽  
Hyeung Kyoo Kim ◽  
Jin-Sun Park ◽  
...  
Keyword(s):  
Primary Aldosteronism ◽  
Cerebral Microbleeds ◽  
Adrenocortical Adenoma

ADRENOCORTICAL ADENOMA WITH PRIMARY ALDOSTERONISM IN CULTURE

1986 ◽  
Vol 36 (11) ◽  
pp. 1659-1668
Author(s):  
Kenji Matsuo ◽  
Hideo Tsuchiyama
Keyword(s):  
Primary Aldosteronism ◽  
Adrenocortical Adenoma

Primary aldosteronism due to adrenocortical adenoma with concurrent ileum carcinoid tumor: case report

Endocrine ◽  
2010 ◽  
Vol 38 (3) ◽  
pp. 313-319 ◽  
Author(s):  
L. Zinnamosca ◽  
L. Petramala ◽  
D. Cotesta ◽  
C. Marinelli ◽  
S. Sciomer ◽  
...  
Keyword(s):  
Case Report ◽  
Carcinoid Tumor ◽  
Primary Aldosteronism ◽  
Adrenocortical Adenoma
Sign in / Sign up

Export Citation Format

Share Document