A ‘wind of change’ to biosimilars: The NOR ‐ SWITCH trial and its extension

2019 ◽  
Vol 285 (6) ◽  
pp. 693-695
Author(s):  
Jonathan Kay
Keyword(s):  
Switch Trial

The cost of switching language in a semantic categorization task

2002 ◽  
Vol 5 (3) ◽  
pp. 241-251 ◽  
Author(s):  
Roswitha E. von Studnitz ◽  
David W. Green
Keyword(s):  
Switch Trial ◽  
Response Type ◽  
Language Switching ◽  
Categorization Task ◽  
Semantic Categorization ◽  
Language Control ◽  
The Cost

German-English bilinguals decided whether a visually presented word, either German or English, referred to an animate or to an inanimate entity. Bilinguals were slower to respond on a language switch trial than on language non-switch trials but only if they had to make the same response as on the prior trial (e.g., two successive “animate” responses). If they had to change their response from the prior trial, a switch of language speeded responses. This interaction between language switching and response type was abolished for the translations of words previously presented. We consider the implications for theories of language control.

INSTEAD: Randomized switch trial of indacaterol and salmeterol/fluticasone combination (SFC) in moderate COPD: Symptoms results

2015 ◽  
Author(s):  
Andrea Rossi ◽  
Thys Van der Molen ◽  
Ricardo Del Olmo ◽  
Alberto Papi ◽  
Luis Wehbe ◽  
...  
Keyword(s):  
Switch Trial

Biosimilar Infliximab (CT-P13) is not Inferior to Originator Infliximab: Explorative IBD Subgroup-Analyses in Crohn's Disease and Ulcerative Colitis from the Nor-Switch Trial

2017 ◽  
Vol 152 (5) ◽  
pp. S65-S66 ◽  
Author(s):  
Kristin K. Joergensen ◽  
Inge C Olsen ◽  
Guro L. Goll ◽  
Merete Lorentzen ◽  
Nils Bolstad ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Switch Trial ◽  
Subgroup Analyses

Perceptions of sexual functioning, prolactin levels and psychopathology in an olanzapine switch trial

2003 ◽  
Vol 60 (1) ◽  
pp. 281
Author(s):  
R.A. Dickson ◽  
W.M. Glazer ◽  
G.J. Remington ◽  
E. Stip ◽  
D.J. Walker ◽  
...  
Keyword(s):  
Sexual Functioning ◽  
Switch Trial

284 Cognitive Deficits due to Insufficient Sleep are Mitigated Following Strenuous Physical Exertion in Firefighters

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A114-A114
Author(s):  
Michelle Stepan ◽  
Kristine Wilckens ◽  
Dave Hostler ◽  
Peter Franzen
Keyword(s):  
Sleep Deprivation ◽  
Task Switching ◽  
Cognitive Deficits ◽  
Treadmill Exercise ◽  
Physical Exertion ◽  
Switch Trial ◽  
Sleep Disruption ◽  
Insufficient Sleep ◽  
Before And After ◽  
Switching Task

Abstract Introduction Insufficient sleep impairs cognitive function which results in costly errors. Firefighter shifts regularly exceed 24-hrs with little to no sleep. Nevertheless, firefighters must maintain and flexibly shift attention in high-pressure scenarios. Firefighters also engage in strenuous physical exertion during fire suppression activities. However, it is unclear whether physical exertion acts as another stressor, exasperating cognitive deficits due to insufficient sleep, or whether physical exertion enhances arousal to reduce cognitive deficits. Moreover, the effects of physical exertion may depend on the type of cognitive process and extent of sleep loss. We examined the effect of physical exertion on vigilant attention and task-switching in firefighters who underwent sleep-deprivation or sleep-disruption. Methods Participants were 17 healthy young adult males who participated in a within-subjects crossover design with three experimental lab visits: sleep-deprivation, sleep-disruption (woken 3 times for 60-min each), and normal sleep. The next day, participants completed a 50-min treadmill exercise task in a heated room in firefighter protective clothing. Participants completed a vigilant attention task (Psychomotor Vigilance Task, PVT) and a task-switching task five to nine times each visit. The five timepoints of interest–before and after the sleep manipulation night, before and after the treadmill exercise task, and recovery (approximately 180-min following exercise)–were examined using linear mixed effects models. Results We analyzed lapses (reaction times [RT]>500ms) on the PVT and switch-trial RT and accuracy on the task-switching task for sleep-deprivation and sleep-disruption conditions relative to normal sleep. Sleep-disruption, p=.001, and sleep-deprivation, p<.001, increased lapses. Sleep-disruption increased switch-trial RT, p=.01, and sleep-deprivation reduced switch-trial accuracy, p=.01. Only switch-trial accuracy improved immediately after the treadmill exercise task and only for the sleep-deprivation condition, p=.01. During recovery, lapses lessened for the sleep-deprivation condition, p=.049, and switch-trial accuracy improved for both sleep-deprivation, p=.01, and sleep-disruption conditions, p=.049. Conclusion Physical exertion reduced task-switching and attentional deficits caused by insufficient sleep, with more benefits observed during recovery. We found no evidence for performance decrements due to physical exertion. Physical exertion may interact with the extent of sleep loss–primarily benefitting performance under conditions of total sleep-deprivation. Support (if any) DSF Charitable Foundation and University of Pittsburgh Clinical and Translational Science Institute UL1TR001857.

scholarly journals Long‐term efficacy and safety of biosimilar infliximab (CT‐P13) after switching from originator infliximab: open‐label extension of the NOR‐SWITCH trial

2019 ◽  
Vol 285 (6) ◽  
pp. 653-669 ◽  
Author(s):  
G. L. Goll ◽  
K. K. Jørgensen ◽  
J. Sexton ◽  
I. C. Olsen ◽  
N. Bolstad ◽  
...  
Keyword(s):  
Switch Trial ◽  
Efficacy And Safety ◽  
Open Label ◽  
Term Efficacy ◽  
Open Label Extension
Sign in / Sign up

Export Citation Format

Share Document