PCSK9 plays a novel immunological role in oxidized LDL-induced dendritic cell maturation and activation of T cells from human blood and atherosclerotic plaque

2018 ◽  
Vol 284 (2) ◽  
pp. 193-210 ◽  
Author(s):  
A. Liu ◽  
J. Frostegård
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Atherosclerotic Plaque ◽  
Human Blood ◽  
Oxidized Ldl ◽  
Dendritic Cell Maturation ◽  
Cell Maturation

Cholera toxin B subunit promotes the induction of regulatory T cells by preventing human dendritic cell maturation

2008 ◽  
Vol 84 (3) ◽  
pp. 661-668 ◽  
Author(s):  
Antonella D'Ambrosio ◽  
Manuela Colucci ◽  
Orsola Pugliese ◽  
Francesca Quintieri ◽  
Monica Boirivant
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Regulatory T Cells ◽  
Dendritic Cell Maturation ◽  
Cell Maturation ◽  
Cholera Toxin B Subunit ◽  
Human Dendritic Cell ◽  
Toxin B ◽  
Cholera Toxin B ◽  
B Subunit

TREM-1 modulates dendritic cell maturation and dendritic cell–mediated T cell activation induced by ox-LDL

2020 ◽  
Author(s):  
Yunkai Wang ◽  
Jie Wang ◽  
Lu Han ◽  
Yun Li Shen ◽  
Jie Yun You ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
Dendritic Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Human Peripheral Blood ◽  
Dendritic Cell Maturation ◽  
Cell Maturation ◽  
Blood Monocytes

Abstract Background: Triggering receptor expressed on myeloid cells (TREM)-1is identified as a major upstream proatherogenic receptor. However, the cellular processes modulated by TREM-1 in the development of atherosclerosis and plaque destabilization has not been fully elucidated. In this study, we investigated the effects of TREM-1 on dendritic cell maturation and dendritic cell–mediated T-cell activation induced by oxidized low-density lipoprotein (ox-LDL) in atherogenesis. Methods: Human peripheral blood monocytes were differentiated to dendritic cells and stimulated by ox-LDL. Naive autologous T cells were co-cultured with pretreated dendritic cells.The expressionof TREM-1 and the production of inflammatory cytokines were assessed by real-time PCR, western blot and ELISA.The expression of immune factors was determined with FACS to evaluate dendritic cell maturation and T-cell activation. Results: Stimulation with ox-LDL promoted dendritic cell maturation, TREM-1 expression and T-cell activation, and exposure of T cells to ox-LDL-treated dendritic cells induced production of interferon-γ and IL-17. Blocking TREM-1 suppressed dendritic cell maturation with low expression of CD1a, CD40, CD86 and HLA-DR, decreased production of TNF-α, IL-1β, IL-6 and MCP-1, and increased secretion of TGF-β and IL-10. In addition, stimulation of ox-LDL induced miR-155, miR-27, Let-7c and miR-185 expression, whereas inhibition of TREM-1 repressed miRNA-155. Silencing TREM-1 or miRNA-155 increased SOCS1 expression induced by ox-LDL. T cells derived from carotid atherosclerotic plaques or healthy individuals showed similar result patterns. Conclusion: These data suggest that TREM-1 modulates maturation of dendritic cells and activation of plaque T cells induced by ox-LDL, a pivotal player in atherogenesis.

scholarly journals CD8 T cells targeting adapted epitopes in chronic HIV infection promote dendritic cell maturation and CD4 T cell trans-infection

2019 ◽  
Vol 15 (8) ◽  
pp. e1007970 ◽  
Author(s):  
Kai Qin ◽  
Sushma Boppana ◽  
Victor Y. Du ◽  
Jonathan M. Carlson ◽  
Ling Yue ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Dendritic Cell ◽  
Hiv Infection ◽  
Cd8 T Cells ◽  
Dendritic Cell Maturation ◽  
Cd4 T Cell ◽  
Cell Maturation ◽  
Trans Infection ◽  
Chronic Hiv Infection

scholarly journals Early cytoskeletal rearrangement during dendritic cell maturation enhances synapse formation and Ca2+ signaling in CD8+ T cells

2004 ◽  
Vol 34 (10) ◽  
pp. 2708-2719 ◽  
Author(s):  
Marco Averbeck ◽  
Thorsten Braun ◽  
Gunther Pfeifer ◽  
Jonathan Sleeman ◽  
Jan Dudda ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Cd8 T Cells ◽  
Synapse Formation ◽  
Dendritic Cell Maturation ◽  
Cell Maturation ◽  
Cytoskeletal Rearrangement

scholarly journals Dendritic cell maturation, but not type I interferon exposure, restricts infection by HTLV-1, and viral transmission to T-cells

2017 ◽  
Vol 13 (4) ◽  
pp. e1006353 ◽  
Author(s):  
Gergès Rizkallah ◽  
Sandrine Alais ◽  
Nicolas Futsch ◽  
Yuetsu Tanaka ◽  
Chloé Journo ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Type I Interferon ◽  
Dendritic Cell Maturation ◽  
Viral Transmission ◽  
Cell Maturation ◽  
Type I

Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells

10.1038/ni722 ◽  
2001 ◽  
Vol 2 (11) ◽  
pp. 1010-1017 ◽  
Author(s):  
Matthew L. Albert ◽  
Mithila Jegathesan ◽  
Robert B. Darnell
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Cd8 T Cells ◽  
Dendritic Cell Maturation ◽  
Cell Maturation ◽  
The Cross

scholarly journals B7-H1 (PD-L1) on T cells is required for T-cell-mediated conditioning of dendritic cell maturation

2009 ◽  
Vol 106 (8) ◽  
pp. 2741-2746 ◽  
Author(s):  
Oezcan Talay ◽  
Ching-Hung Shen ◽  
Lieping Chen ◽  
Jianzhu Chen
Keyword(s):  
T Cells ◽  
T Cell ◽  
Dendritic Cell ◽  
Dendritic Cell Maturation ◽  
Cell Maturation
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