scholarly journals Functional and homeostatic defects of regulatory T cells in patients with coronary artery disease

2015 ◽  
Vol 279 (1) ◽  
pp. 63-77 ◽  
Author(s):  
L. Hasib ◽  
A. K. Lundberg ◽  
H. Zachrisson ◽  
J. Ernerudh ◽  
L. Jonasson
Keyword(s):  
Coronary Artery Disease ◽  
T Cells ◽  
Coronary Artery ◽  
Regulatory T Cells ◽  
Artery Disease

Methylation of FOXP3 in regulatory T cells is related to the severity of coronary artery disease

2013 ◽  
Vol 228 (2) ◽  
pp. 346-352 ◽  
Author(s):  
Lei Jia ◽  
Ling Zhu ◽  
Ji Zheng Wang ◽  
Xiao Jian Wang ◽  
Jing Zhou Chen ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
T Cells ◽  
Coronary Artery ◽  
Regulatory T Cells ◽  
Artery Disease

scholarly journals Evaluation of CD25+CD4+ Regulatory T-Lymphocyte Subpopulations in Coronary Artery Diseases Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-5
Author(s):  
Ewa Romuk ◽  
Bronisława Skrzep-Poloczek ◽  
Celina Wojciechowska ◽  
Wojciech Jacheć ◽  
Bogdan Mazur ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Heart Disease ◽  
T Cells ◽  
Heart Disease ◽  
Coronary Artery ◽  
Regulatory T Cells ◽  
T Lymphocyte ◽  
Lymphocyte Subpopulations ◽  
T Lymphocyte Subpopulations ◽  
Artery Disease

Background. The development of atherosclerosis may be associated with a deficiency in the regulatory T-cells, which should serve a protective function and inhibit the accumulation of lymphocytes and macrophages. The aim of this study was the analysis of the T-lymphocyte subpopulations, particularly CD4+CD25+ regulatory T-cells in patients with different form of coronary artery disease. Materials and Methods. In the study 30 patients with stable coronary heart disease and 30 patients with unstable coronary heart disease take part. Lymphocytes subpopulations were measured with flow cytometry technique. The analysis of the treated cells parameters was performed with the use of CellQuest program. Results. We have observed statistically significant increase in activated lymphocytes subpopulations in patients with unstable coronary artery disease in comparison to stable group and significant decrease in CD25+, CD25/CD3+, and CD25/CD4+ subpopulations in unstable patients comparing to stable patients group. Conclusions. A strong interest in regulatory lymphocytes is due to their possible therapeutic use as a factor in modifying the immune response in various diseases. Questions regarding the role of regulatory T-cells in the development of atherosclerosis remain unclear. Mechanisms of the regulatory T-cells impact on suppression of atherosclerosis need more experiments to be done.

Statins, regulatory T cells, and pediatric graft coronary artery disease

2009 ◽  
Vol 13 (1) ◽  
pp. 139-140 ◽  
Author(s):  
Mark R. Goldstein ◽  
Luca Mascitelli ◽  
Francesca Pezzetta
Keyword(s):  
Coronary Artery Disease ◽  
T Cells ◽  
Coronary Artery ◽  
Regulatory T Cells ◽  
Artery Disease

scholarly journals Persistent accumulation of interferon-γ-producing CD8+CD56+ T cells in blood from patients with coronary artery disease

2012 ◽  
Vol 224 (2) ◽  
pp. 515-520 ◽  
Author(s):  
Ida Bergström ◽  
Karin Backteman ◽  
Anna Lundberg ◽  
Jan Ernerudh ◽  
Lena Jonasson
Keyword(s):  
Coronary Artery Disease ◽  
T Cells ◽  
Coronary Artery ◽  
Interferon Γ ◽  
Artery Disease

scholarly journals RNA Sequencing of Blood in Coronary Artery Disease: Involvement of Regulatory T Cell Imbalance

2021 ◽  
Author(s):  
Timothy McCaffrey ◽  
Ian Toma ◽  
Zhaoquing Yang ◽  
Richard Katz ◽  
Jonathan Reiner ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
T Cells ◽  
Coronary Artery ◽  
Rna Sequencing ◽  
Single Molecule ◽  
Whole Blood ◽  
Bioinformatic Analysis ◽  
Current Standard ◽  
Immune Synapse ◽  
Artery Disease

Abstract RATIONALE: Cardiovascular disease had a global prevalence of 523 million cases and 18.6 million deaths in 2019. The current standard for diagnosing coronary artery disease (CAD) is coronary angiography. Surprisingly, despite well-established clinical indications, up to 40% of the one million invasive cardiac catheterizations return a result of ‘no blockage’. OBJECTIVE: The present studies employed RNA sequencing of whole blood to identify an RNA signature in patients presenting with a clinical suspicion of CAD.METHODS AND RESULTS: Whole blood RNA was depleted of ribosomal RNA (rRNA) and analyzed by single-molecule sequencing of RNA (RNAseq) to identify transcripts associated with CAD (TRACs) in a discovery group of 96 patients presenting for elective coronary catheterization. The resulting transcript counts were compared between groups to identify differentially expressed genes (DEGs). Surprisingly, 98% of DEGs/TRACs were down-regulated ~1.7-fold in patients with mild to severe CAD (>20% stenosis). The TRACs were independent of comorbid risk factors for CAD, such as gender, hypertension, and smoking. Bioinformatic analysis identified an enrichment in transcripts such as FoxP1, ICOSLG, IKZF4/Eos, SMYD3, TRIM28, and TCF3/E2A that are likely markers of regulatory T cells (Treg), consistent with known reductions in Tregs in CAD. A validation cohort of 80 patients confirmed the overall pattern (92% down-regulation) and supported many of the Treg-related changes. TRACs were enriched for transcripts associated with stress granules, which sequester RNAs, and ciliary and synaptic transcripts, possibly consistent with changes in the immune synapse of developing T cells.CONCLUSIONS: These studies identify a novel mRNA signature of a Treg-like defect in CAD patients and provides a blueprint for a diagnostic test for CAD. The pattern of changes is consistent with stress-related changes in the maturation of T and Treg cells, possibly due to changes in the immune synapse.

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