Effect on Clinical Restenosis of an Ultra-Thin-Strut Bare Metal Cobalt-Chromium Stent Versus a Thin-Strut Stainless Steel Stent

2016 ◽  
Vol 29 (3) ◽  
pp. 300-310 ◽  
Author(s):  
Simona Silenzi ◽  
Pierfrancesco Grossi ◽  
Luca Mariani ◽  
Chiara Fraccaro ◽  
Fabio Vagnarelli ◽  
...  
Keyword(s):  
Stainless Steel ◽  
Bare Metal ◽  
Cobalt Chromium ◽  
Cobalt Chromium Stent

Randomized comparative trial of a thin-strut bare metal cobalt-chromium stent versus a sirolimus-eluting stent for coronary revascularization

2007 ◽  
Vol 69 (6) ◽  
pp. 790-798 ◽  
Author(s):  
Paolo Ortolani ◽  
Antonio Marzocchi ◽  
Cinzia Marrozzini ◽  
Tullio Palmerini ◽  
Francesco Saia ◽  
...  
Keyword(s):  
Coronary Revascularization ◽  
Comparative Trial ◽  
Bare Metal ◽  
Cobalt Chromium ◽  
Cobalt Chromium Stent ◽  
Sirolimus Eluting Stent

scholarly journals Comparative Evaluation of Stainless Steel Stent (Sirolimus) and Cobalt Chromium Stent (Sirolimus) In Patient with Coronary Artery Disease

2016 ◽  
Vol 8 (04) ◽  
Author(s):  
J. Shah ◽  
J. Patel ◽  
S. Dani
Keyword(s):  
Coronary Artery Disease ◽  
Stainless Steel ◽  
Coronary Artery ◽  
Coronary Intervention ◽  
Cobalt Chromium ◽  
Cardiac Events ◽  
Target Vessel Revascularization ◽  
Adverse Cardiac Events ◽  
Cobalt Chromium Stent ◽  
Artery Disease

Coronary Artery Disease (CAD) occurs when the arteries of the heart that normally provide blood and oxygen to the heart are narrowed or even completely blocked due to clot formation. The Stenting implantation composes 84.2% of all Percutaneous coronary intervention (PCI). Despite the widespread use of these devices, bare metal stents (BMS) have been associated with a 20-30% restenosis rate which requires reintervention. In December 2006, US Food and Drug Administration cardiovascular experts concluded that for many patients, such as those with uncomplicated medical histories who undergo elective stenting of simple coronary blockages, drug-eluting stents remain a safe and appropriate therapy. Previously reports are suggestive of similar clinical outcomes for stainless steel and cobalt chromium bare metal stent. No reports are available for comparison of sirolimus eluting stainless steel stent and sirolimus eluting cobalt chromium stent. The present study was undertaken with the objective of comparative evaluation of Stainless Steel Stent (Sirolimus) and Cobalt Chromium Stent (Sirolimus) in Patient with Coronary Artery Disease. A single centric, retrospective, nonrandomized study involving 118 patients who have undergone PCI from January 2011 to March 2012 implanted with either Sirolimus Stainless Steel Stent (SSSS) or Sirolimus Cobalt Chromium Stents (SCCS) were included in the study. Primary objective was to determine and compare the clinical outcome and rates of target vessel revascularization (TVR) in patients undergoing primary PCI for CAD patients who were treated with Sirolimus cobalt-chromium stents and Sirolimus stainless steel stents. The secondary outcomes of study were Major Adverse Cardiac Events, mortality at the end of 1 month, 6 month and 1 year of outcomes. At 1 month follow up there was no significant difference between two groups (p = 0.96). The individual clinical component showed no difference in occurrence of death (p = 0.29), MI (p = 0.29) and TLR (p = 0.96) at end of 6 month. The cumulative clinical outcome at 1 year rate of target vessel revascularization TVR (SSSS 1.75% versus SCCS 0%, p = 0.29), target lesion revascularization (SSSS 5.27% versus SCCS 1.63%, p = 0.27), and Major Adverse Cardiac Events (SSSS 22.80% versus SCCS 13.11%, p = 0.16). This study showed that among Coronary artery disease (CAD) patients undergoing primary percutaneous coronary intervention, sirolimus stainless steel stent showed similar efficacy and safety to sirolimus cobalt chromium stent.

scholarly journals Penyakit Arteri Koroner: Pilih CABG atau PCI?

2015 ◽  
pp. 1-3
Author(s):  
Yoga Yuniadi
Keyword(s):  
Stainless Steel ◽  
Patency Rate ◽  
Bare Metal Stent ◽  
Drug Eluting Stent ◽  
Bare Metal ◽  
Cobalt Chromium ◽  
Metal Stent ◽  
Off Pump ◽  
Drug Eluting

Strategi revaskularisasi pada penyakit arteri koroner (PAK) terus menjadi bahan debat di kalangan kardiologi. Berbagai uji klinis yang telah dilakukan menunjukkan hasil yang bervariasi dan harus ditelaah secara detil karena persoalan strategi revaskularisasi menjadi masalah yang tidak sederhana tetapi harus memperhatikan subset pasien yang befvariasi untuk mendapatkan hasil yang terbaik. Prinsip dasar yang harus tetap dijaga oleh para kardiolog adalah keputusan medis harus berorientasi pada pasien. Patient first!Perbandingan secara tidak langsung antara bedah pintas arteri koroner (BPAK/CABG) dengan intervensi koroner perkutan (IKP/PCI) menunjukkan dengan CABG keperluan pengulangan revaskularisasi lebih sedikit. Masalah yang selalu dipertanyakan dalam membandingkan kedua teknik revaskularisasi itu adalah pengaruh perkembangan teknologi stent terhadap luaran pasien. Berbeda dengan teknik CABG relatif tidak banyak berubah yaitu terdiri dari teknik on- atau off-pump, sedangkan teknologi stent berkembang cepat dan mungkin akan memberikan luaran yang berbeda karena stent generasi terakhir dipercaya memiliki patency rate yang lebih baik. Teknologi stent berkembang dari bare-metal stent ke drug-eluting stent, kemudian drug eluting stent juga berevolusi mulai dari generasi pertama yang memakai obat sirolimus atau paclitaxel ke generasi kedua yang memakai obat everolimus atau zotarolimus. Demikian juga farmako-teknologi polymer yang berkembang ke arah polymer-free stent. Dalam hal platform stent dimulai dari stainless steel, cobalt chromium, platinum dan terakhir memakai polylactyic acid yang dapat diserap.

Abstract 16775: Efficacy and Safety of a Thinner-strut Silicon Carbide-coated Cobalt Chromium Bare-metal Stent Compared to a Thin-strut Uncoated Cobalt Chromium Bare-metal Stent in Large Vessel Stenting: Insights From Two Prospective Randomised All-comers Trials

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Kim W Hansen ◽  
Rikke Sørensen ◽  
Raban Jeger ◽  
Christoph Kaiser ◽  
Matthias Pfisterer ◽  
...  
Keyword(s):  
Silicon Carbide ◽  
Cardiac Death ◽  
Bare Metal Stent ◽  
Bare Metal ◽  
Target Vessel ◽  
Efficacy And Safety ◽  
Cobalt Chromium ◽  
Metal Stent ◽  
Target Vessel Revascularization ◽  
New Generation

Introduction: The new generation thinner-strut silicon carbide (SiC) coated cobalt chromium (CoCr) bare-metal stents (BMS) are designed to accelerate rapid endothelialisation and reduce thrombogenicity when implanted in coronary arteries. However, smaller studies suggest reduced efficacy with higher rates of symptomatic restenosis in patients receiving the newer generation BMS. Objective: We investigated the efficacy and safety of a new generation thinner-strut SiC coated CoCr BMS (SCC-BMS) as compared to an older thin-strut uncoated CoCr BMS (UC-BMS) in patients presenting with coronary artery disease requiring stenting of large vessels (≥3.0mm) and thus at low risk of restenosis. Methods: We included all patients randomized to SCC- (n=761) or UC-BMS (n=765) in the BASKET-PROVE II and I trials, respectively. Design, patients, interventions and follow-up were similar between trials except differing regimens of dual antiplatelet therapy. The primary endpoint was clinically driven target-vessel revascularization within 24 months. Safety endpoints of cardiac death, non-fatal myocardial infarction (MI), and definite/probable stent thrombosis were also assessed. We used Cox proportional hazards regressions to estimate relative hazards adjusting for known confounders. Results: Demographics, clinical presentation, and risk factors were comparable between the groups, but patients receiving SCC-BMS underwent less complex procedures. Rates of the primary endpoint were 10.4% in the SCC-BMS group and 8.4% among patients receiving UC-BMS yielding an adjusted relative hazard (HR) of 1.46 ([1.03-2.07], p=0.032). Estimates for the safety endpoints were: cardiac death (1.8% vs. 2.4% ; HR 0.77 [0.36-1.59], p=0.46), non-fatal MI (3.2% vs. 2.5% ; HR 1.68 [0.88-3.21], p=0.11), and definite/probable stent thrombosis (0.8% vs. 1.0% ; HR 0.97 [0.32-3.00], p=0.96). We detected no particular subgroups driving the increased risk of target-vessel revascularization in the SCC-BMS group. Conclusions: In patients requiring stenting of large coronary arteries, use of the newer generation SCC-BMS was associated with a higher risk of symptomatic restenosis despite less complex procedures compared to the UC-BMS with no signs of an offsetting safety benefit.

scholarly journals FRACTURE LOAD OF SILVER SOLDERED JOINTS ON STAINLESS STEEL AND COBALT-CHROMIUM ORTHODONTIC WIRES WITH VARIOUS JOINING CONFIGURATIONS

2021 ◽  
pp. 26-35
Keyword(s):  
Tensile Strength ◽  
Stainless Steel ◽  
Steel Wire ◽  
Fracture Load ◽  
Cobalt Chromium ◽  
Orthodontic Wires ◽  
Orthodontic Wire ◽  
The Wire ◽  
Site Planning ◽  
Band Material

The current research compared and analysed the tensile strength of silver soldered stainless steel and cobalt-chromium orthodontic wire joints with band material The effect of joint site planning on various orthodontic joining configurations was investigated. A total of sixty wire specimens were chosen, thirty in the stainless-steel group and thirty in the cobalt – chromium group. Again, each group's sample was divided into three subgroups, namely End – End, Round, and Orthodontic band material. The study findings suggested all three configurations can be used to make silver soldered joints regardless of the wire consistency. When subjecting the wire to joint site planning, however, stainless steel wire should be used with its limitations in mind.

scholarly journals FRACTURE LOAD OF SILVER SOLDERED JOINTS ON STAINLESS STEEL AND COBALT-CHROMIUM ORTHODONTIC WIRES WITH VARIOUS JOINING CONFIGURATIONS

2021 ◽  
pp. 26-35
Keyword(s):  
Tensile Strength ◽  
Stainless Steel ◽  
Steel Wire ◽  
Fracture Load ◽  
Cobalt Chromium ◽  
Orthodontic Wires ◽  
Orthodontic Wire ◽  
The Wire ◽  
Site Planning ◽  
Band Material

The current research compared and analysed the tensile strength of silver soldered stainless steel and cobalt-chromium orthodontic wire joints with band material The effect of joint site planning on various orthodontic joining configurations was investigated. A total of sixty wire specimens were chosen, thirty in the stainless-steel group and thirty in the cobalt – chromium group. Again, each group's sample was divided into three subgroups, namely End – End, Round, and Orthodontic band material. The study findings suggested all three configurations can be used to make silver soldered joints regardless of the wire consistency. When subjecting the wire to joint site planning, however, stainless steel wire should be used with its limitations in mind.

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