Bilateral adrenal metastases of endometrial cancer with adrenal insufficiency

2021 ◽  
Author(s):  
Tetsuro Shiraishi ◽  
Iori Kisu ◽  
Kanako Nakamura ◽  
Moito Iijima ◽  
Kiyoko Matsuda ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Adrenal Insufficiency ◽  
Adrenal Metastases

scholarly journals ADRENAL INSUFFICIENCY WITH NORMAL SERUM CORTISOL DUE TO LARGE, BILATERAL ADRENAL METASTASES

2018 ◽  
Vol 4 (4) ◽  
pp. e282-e284
Author(s):  
Lauren M. Maiorini ◽  
Kent Chan ◽  
Lawrence E. Shapiro
Keyword(s):  
Adrenal Insufficiency ◽  
Serum Cortisol ◽  
Normal Serum ◽  
Adrenal Metastases

Surgical Management of Isolated Bilateral Adrenal Metastases from Colon Carcinoma Causing Adrenal Insufficiency

2001 ◽  
Vol 67 (1) ◽  
pp. 113-116 ◽  
Author(s):  
Alfonso Crisci ◽  
Giuseppe Cartei ◽  
Pietro De Antoni ◽  
Gianluca Giannarini ◽  
Umberto Moro ◽  
...  
Keyword(s):  
Adrenal Insufficiency ◽  
Colon Carcinoma ◽  
Surgical Management ◽  
Adrenal Metastases

Adrenal insufficiency after stereotactic body radiation therapy for bilateral adrenal metastases

2015 ◽  
Vol 5 (3) ◽  
pp. e177-e181 ◽  
Author(s):  
Zabi Wardak ◽  
Jeffrey Meyer ◽  
Hans Ghayee ◽  
Lalan Wilfong ◽  
Robert Timmerman
Keyword(s):  
Radiation Therapy ◽  
Adrenal Insufficiency ◽  
Stereotactic Body Radiation Therapy ◽  
Adrenal Metastases ◽  
Stereotactic Body Radiation

scholarly journals Adrenal insufficiency due to bilateral adrenal metastases – A systematic review and meta-analysis

Heliyon ◽  
2019 ◽  
Vol 5 (5) ◽  
pp. e01783 ◽  
Author(s):  
Philippa H. Tallis ◽  
R. Louise Rushworth ◽  
David J. Torpy ◽  
Henrik Falhammar
Keyword(s):  
Systematic Review ◽  
Adrenal Insufficiency ◽  
Meta Analysis ◽  
Adrenal Metastases

scholarly journals Adrenocortical function in patients with macrometastases of the adrenal gland

2000 ◽  
pp. 91-97 ◽  
Author(s):  
A Lutz ◽  
M Stojkovic ◽  
M Schmidt ◽  
W Arlt ◽  
B Allolio ◽  
...  
Keyword(s):  
Adrenal Gland ◽  
Adrenal Insufficiency ◽  
Malignant Tumors ◽  
Cross Sectional Study ◽  
Adrenocortical Function ◽  
Adrenal Metastases ◽  
Cross Sectional ◽  
Study Population ◽  
The Impact ◽  
Bilateral Metastases

OBJECTIVE: Metastases of the adrenal gland are a frequent finding in patients with malignant tumors like bronchogenic carcinoma or breast cancer. Only limited and conflicting data on adrenocortical function in these patients are available. DESIGN: Cross-sectional study. METHODS: We investigated the impact of adrenal macrometastases on adrenocortical function in a series of 28 tumor patients using the ACTH(1-24) stimulation test and dexamethasone suppression test. Seven normal controls (Con), eleven patients without adrenal metastases (No Met), eight patients with unilateral (Uni Met) and nine patients with bilateral adrenal metastases (Bil Met) were investigated. RESULTS: The prevalence of adrenal insufficiency was low in our study population, with only two of nine patients with bilateral metastases having subclinical adrenocortical insufficiency. In the remaining patients with uni- or bilateral metastases, baseline and stimulated cortisol concentrations were higher than in controls and cancer patients without metastases (baseline cortisol (in nmol/l): Con: 307+/-33.2 vs Uni Met: 440+/-53.5, and Bil Met: 637.6+/-92.1, P=0.04 by ANOVA; cortisol 60 min after ACTH(1-24): Con: 794.6+/-41.2 vs Uni Met: 990.8+/-92.9, and Bil Met: 1151.4+/-155.5, P=0.03 by ANOVA). Simultaneously, baseline and stimulated serum aldosterone concentrations were significantly blunted in the tumor groups. CONCLUSIONS: Adrenal insufficiency is infrequent and develops only in patients with bilateral metastases. However, the majority of patients have activation of the hypothalamic-pituitary-adrenal axis despite adrenal metastases with strongly elevated cortisol concentrations.

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