Trends of fetal chromosome analysis by amniocentesis before and after beginning of noninvasive prenatal testing: A single‐center experience in Japan

2021 ◽  
Author(s):  
Shinobu Goto ◽  
Nobuhiro Suzumori ◽  
Kyoko Kumagai ◽  
Ayano Otani ◽  
Shino Ogawa ◽  
...  
Keyword(s):  
Prenatal Testing ◽  
Chromosome Analysis ◽  
Single Center ◽  
Noninvasive Prenatal Testing ◽  
Single Center Experience ◽  
Before And After

scholarly journals Increased Rate of Incidental Colorectal Malignant Polyps: A Single-Center Experience

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
T. Buchbjerg ◽  
R. Kroijer ◽  
I. Al-Najami ◽  
K. Urth Hansen ◽  
G. Baatrup
Keyword(s):  
Resection Margin ◽  
Single Center ◽  
Indication For Surgery ◽  
Residual Cancer ◽  
Single Center Experience ◽  
Primary Indication ◽  
Additional Surgery ◽  
Before And After ◽  
Endoscopic Microsurgery ◽  
Malignant Polyps

Background and Aims. To investigate the incidence and treatment of colorectal malignant polyps before and after colorectal cancer screening initiation in March 2014 in a single Danish center. Materials and Methods. 71 patients with colorectal malignant polyps in a single center from 2012 to 2015 were reported retrospectively. Results. There was a significant increase (P<0.01) in the incidence of colorectal malignant polyps from 2012 to 2013 and 2014 to 2015 (8 versus 63) relative to the increase in colonoscopies with polypectomy (1029 versus 2706). It coincides with the initiation of screening in March 2014. A positive, nonradical, or undeterminable resection margin was found in 57% (36/63), and this was the primary indication for surgery. Additional surgery was done in 49% of the cases (31/63) with 27 bowel resections and 4 transanal endoscopic microsurgery (TEM) procedures. Nineteen percent (5/27) had either residual cancer cells at the polypectomy site or lymph node metastasis in the resection specimens. Conclusion. Colorectal malignant polyps have become more frequent after the initiation of screening. The primary, and operator-dependent, indicator for surgery is the positive, nonradical, or undeterminable resection margin, and 1 in 5 operated has remaining cancer in the resection specimens.

scholarly journals Cancer Diagnoses Following Abnormal Noninvasive Prenatal Testing: A Case Series, Literature Review, and Proposed Management Model

2021 ◽  
pp. 1001-1012
Author(s):  
Eryn Dow ◽  
Alison Freimund ◽  
Kortnye Smith ◽  
Rodney J. Hicks ◽  
Peter Jurcevic ◽  
...  
Keyword(s):  
Case Series ◽  
Prenatal Testing ◽  
High Sensitivity ◽  
Maternal Blood ◽  
Noninvasive Prenatal Testing ◽  
Cell Free Dna ◽  
Single Center Experience ◽  
Cancer Breast ◽  
Free Dna ◽  
Positron Emission

Noninvasive prenatal testing (NIPT) is a screening test for fetal chromosomal aneuploidy using cell-free DNA derived from maternal blood. It has been rapidly accepted into obstetric practice because of its application from 10-weeks' gestation, and its high sensitivity and specificity. NIPT results can be influenced by several factors including placental or maternal mosaicism and co-twin demise; cell-free DNA from a maternal origin can also complicate interpretation, with evidence that NIPT can detect previously unsuspected malignancies. This study aimed to develop management guidelines for women with NIPT results suspicious of maternal malignancy. The Peter MacCallum Cancer Center's experience of seven cases where abnormal NIPT results led to investigation for maternal malignancy between 2016 and 2019 were reviewed, along with the published literature. Six of the seven women (86%) referred for investigation were diagnosed with advanced malignancies, including colorectal cancer, breast cancer, melanoma, and Hodgkin lymphoma. Based on our single-center experience, as well as the available literature, guidelines for the investigation of women with NIPT results suspicious of malignancy are proposed, including utilization of fluorodeoxyglucose positron emission tomography-computed tomography, which had a high concordance with other investigations and diagnoses. These guidelines include maternal and fetal investigations, as well as consideration of the complex medical, psychologic, social, and ethical needs of these patients and their families.

scholarly journals Transjugular intrahepatic portal shunt in the treatment of portal hypertension due to cirrhosis: single center experience

BMC Surgery ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Yun Chen ◽  
Hanyu Qiu ◽  
Xiaomei Zhang
Keyword(s):  
Portal Hypertension ◽  
Liver Function ◽  
Portal Pressure ◽  
Single Center ◽  
Short Term ◽  
Middle Term ◽  
Single Center Experience ◽  
Before And After ◽  
Serum Biochemical

Abstract Aim To investigate clinical efficacy of transjugular intrahepatic portal shunt (TIPS) for the treatment of cirrhotic portal hypertension. Methods 71 cases of patients with cirrhotic portal hypertension and esophageal and gastric variceal bleeding hospitalized from January 2014 to June 2017 were enrolled and treated with TIPS. The change of portal pressure and serum biochemical indexes before and after TIPS were compared, and re-hemorrhage rate, ascites incidence, complications, and survival rate were calculated. Results 71 patients (male/female 47/24, aged 29–77 years, average 48.9 ± 9.8 years) with cirrhotic portal hypertension received TIPS. The success rate of TIPS was 93% (66/71). During 1–24 months (mean 12.5 ± 7 months) follow-up of 66 patients, 61 cases survived and 5 cases died. The portal pressure decreased significantly from 40.48 ± 3.15 cmH2O to 23.59 ± 4.41 cmH2O after TIPS (P < 0.05). During the follow-up, the incidence of hepatic encephalopathy was 12.1%, the incidence of re-hemorrhage was 18.2%, and there were 4 cases of stent dysfunction, with 1 case of bare stent and 3 cases of dual stent. Conclusion TIPS is an effective procedure for the treatment of cirrhotic portal hypertension complications, since it can reduce portal pressure and significantly alleviate ascites. Liver function is impaired in short-term after TIPS, but TIPS has no significant effect on liver function in middle-term.

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