Clinical presentation, treatment, and outcomes associated with vaginal intraepithelial neoplasia: A retrospective study of 118 patients

2021 ◽  
Author(s):  
Dake Yu ◽  
Pengpeng Qu ◽  
Meihua Liu
Keyword(s):  
Retrospective Study ◽  
Clinical Presentation ◽  
Intraepithelial Neoplasia ◽  
Vaginal Intraepithelial Neoplasia

scholarly journals A Retrospective Study of 657 Women With Vaginal Intraepithelial Neoplasia (VaIN)

2021 ◽  
Author(s):  
Fanhui Meng ◽  
Yunyun Cao ◽  
Yudong Wang
Keyword(s):  
Retrospective Study ◽  
Clinical Characteristics ◽  
Intraepithelial Neoplasia ◽  
Diagnostic Methods ◽  
The Other ◽  
International Peace ◽  
Hpv Dna ◽  
Vaginal Intraepithelial Neoplasia ◽  
And Child Health ◽  
Health Hospital

Abstract Objective: The aim of this study was to explore the clinical characteristics of patients with VaIN and identify more sensitive diagnostic methods.Methods: This study retrospectively analyzed 657 patients with VaIN from the International Peace Maternal and Child Health Hospital in Shanghai during a ten-year period. Results: Among the 657 patients, 26.5% were diagnosed with VaIN 2/3. The proportions of patients with VaIN 2/3 among those who did and did not undergo hysterectomy were 39.5% and 24.7%, respectively. The sensitivity of cytology for VaIN in those with only VaIN, VaIN concomitant with cervical or vulvar lesions, and posthysterectomy VaIN was 56.7%, 66.5%, and 72.3%, respectively. The sensitivity of hrHPV for VaIN in the same categories was 87.7%, 86.5%, and 74.3%, respectively. The sensitivity of cytology and hrHPV cotesting for VaIN in the same categories was 95.2%, 95.6%, and 95.0%, respectively. In patients who did not undergo hysterectomy, HPV16 was detected in 9.5% of VaIN 1 lesions among the HPV DNA-positive patients, while the other 12 types of HPV were detected in 62.6% of VaIN 1 lesions. In patients who underwent hysterectomy, HPV16 was detected in 2.1% of VaIN 1 lesions, and the other 12 types of HPV were detected in 54.2% of VaIN 1 lesions.Conclusions: A combination of cytology and colposcopy could increase the sensitivity of the diagnosis of VaIN. The other 12 high-risk types of HPV positive may be more closely related to VAIN 1, more attention should be paid.

Accuracy of colposcopic findings in detecting vaginal intraepithelial neoplasia: a retrospective study

2020 ◽  
Vol 301 (3) ◽  
pp. 769-777 ◽  
Author(s):  
Frederik A. Stuebs ◽  
Martin C. Koch ◽  
Grit Mehlhorn ◽  
Paul Gass ◽  
Carla E. Schulmeyer ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Intraepithelial Neoplasia ◽  
Vaginal Intraepithelial Neoplasia

A retrospective study of 152 women with vaginal intraepithelial neoplasia

2015 ◽  
Vol 133 (1) ◽  
pp. 80-83 ◽  
Author(s):  
Jing Zhang ◽  
Xiaohan Chang ◽  
Yafei Qi ◽  
Yao Zhang ◽  
Shulan Zhang
Keyword(s):  
Retrospective Study ◽  
Intraepithelial Neoplasia ◽  
Vaginal Intraepithelial Neoplasia

Clinical presentation, treatment and outcome of vaginal intraepithelial neoplasia

2015 ◽  
Vol 293 (2) ◽  
pp. 415-419 ◽  
Author(s):  
Matthias Jentschke ◽  
Victoria Hoffmeister ◽  
Philipp Soergel ◽  
Peter Hillemanns
Keyword(s):  
Clinical Presentation ◽  
Intraepithelial Neoplasia ◽  
Vaginal Intraepithelial Neoplasia

scholarly journals A Retrospective Study of Cytology, High-Risk HPV, and Colposcopy Results of Vaginal Intraepithelial Neoplasia Patients

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Qing Cong ◽  
Yu Song ◽  
Qing Wang ◽  
Hongwei Zhang ◽  
Shujun Gao ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Retrospective Study ◽  
High Risk ◽  
Early Detection ◽  
Intraepithelial Neoplasia ◽  
Obstetrics And Gynecology ◽  
Vaginal Intraepithelial Neoplasia ◽  
Sample Data ◽  
Intact Uterus ◽  
High Risk Hpv

There is currently no large sample data of cytology, high-risk human papillomavirus (hrHPV), and colposcopy results of vaginal intraepithelial neoplasia (VaIN) in women who underwent hysterectomy and those who did not. We aim to explore the values of cytology, hrHPV, and colposcopy reports in detecting VaIN. A retrospective study of women diagnosed with VaIN by colposcopy-directed biopsy was performed at the Obstetrics and Gynecology Hospital of Fudan University, China, between January 1, 2014, and December 31, 2014. A total of 529 cases of VaIN were diagnosed, including 16.1% VaIN2/3 and 83.9% VaIN1. The ratio of VaIN2/3 in VaIN among patients after hysterectomy and with an intact uterus was 35.1% and 12.0%, respectively. The sensitivity of cytology for VaIN2/3 in only, concomitant, and posthysterectomy VaIN was 42.1%, 80.0%, and 80.8%, respectively. The sensitivity of hrHPV and cytology/hrHPV cotesting for VaIN2/3 in patients with an intact uterus versus those after hysterectomy was 93.5% versus 92.3% and 92.0% versus 100.0%, respectively. Notably, 13.3% of the patients with VaIN and 9.7% of the patients with VaIN2/3 underwent hysterectomy for noncervical diseases. The sensitivity of cytology and hrHPV for VaIN is noninferior to that of CIN2+, and thus these methods can help in the early detection of VaIN effectively.

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