scholarly journals Protective effects of berberine in a rat model of polycystic ovary syndrome mediated via the PI3K / AKT pathway

2021 ◽  
Author(s):  
Jia Yu ◽  
Caifei Ding ◽  
Zhoujia Hua ◽  
Xuejuan Jiang ◽  
Chenye Wang
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Rat Model ◽  
Polycystic Ovary ◽  
Akt Pathway ◽  
Protective Effects ◽  
Ovary Syndrome

scholarly journals Stress-induced activation of ovarian heat shock protein 90 in a rat model of polycystic ovary syndrome

2011 ◽  
Vol 38 (2) ◽  
pp. 396-407 ◽  
Author(s):  
Eunkuk Park ◽  
John F. Cockrem ◽  
Kyung-Hoon Han ◽  
Doh-Hee Kim ◽  
Min-Hyung Jung ◽  
...  
Keyword(s):  
Heat Shock ◽  
Polycystic Ovary Syndrome ◽  
Heat Shock Protein ◽  
Rat Model ◽  
Polycystic Ovary ◽  
Heat Shock Protein 90 ◽  
Ovary Syndrome

GnRH receptor autoantibodies induce polycystic ovary syndrome‐like features in a rat model

2021 ◽  
Author(s):  
Hongliang Li ◽  
Yankai Guo ◽  
Gege Zhang ◽  
Jielin Deng ◽  
Hayley Fischer ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Rat Model ◽  
Polycystic Ovary ◽  
Gnrh Receptor ◽  
Ovary Syndrome

scholarly journals Hyperandrogenism and Insulin Resistance, Not Changes in Body Weight, Mediate the Development of Endothelial Dysfunction in a Female Rat Model of Polycystic Ovary Syndrome (PCOS)

Endocrinology ◽  
2015 ◽  
Vol 156 (11) ◽  
pp. 4071-4080 ◽  
Author(s):  
Amanda Hurliman ◽  
Jennifer Keller Brown ◽  
Nicole Maille ◽  
Maurizio Mandala ◽  
Peter Casson ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
Weight Gain ◽  
Insulin Sensitivity ◽  
Endothelial Dysfunction ◽  
Polycystic Ovary Syndrome ◽  
Rat Model ◽  
Polycystic Ovary ◽  
Phase 1 ◽  
Ovary Syndrome

This study was designed to differentiate the contributions of hyperandrogenism, insulin resistance (IR), and body weight to the development of endothelial dysfunction in polycystic ovary syndrome and determine the effectiveness of insulin sensitization and antiandrogenic therapy after the establishment of vascular and metabolic dysfunction using a rat model of polycystic ovary syndrome. We hypothesized that the observed endothelial dysfunction was a direct steroidal effect, as opposed to changes in insulin sensitivity or body weight. Prepubertal female rats were randomized to the implantation of a pellet containing DHT or sham procedure. In phase 1, DHT-exposed animals were randomized to pair feeding to prevent weight gain or metformin, an insulin-sensitizing agent, from 5 to 14 weeks. In phase 2, DHT-exposed animals were randomized to treatment with metformin or flutamide, a nonsteroidal androgen receptor blocker from 12 to 16 weeks. Endothelial function was assessed by the vasodilatory response of preconstricted arteries to acetylcholine. Serum steroid levels were analyzed in phase 1 animals. Fasting blood glucose and plasma insulin were analyzed and homeostasis model assessment index calculated in all animals. Our data confirm the presence of endothelial dysfunction as well as increased body weight, hypertension, hyperinsulinemia, and greater IR among DHT-treated animals. Even when normal weight was maintained through pair feeding, endothelial dysfunction, hyperinsulinemia, and IR still developed. Furthermore, despite weight gain, treatment with metformin and flutamide improved insulin sensitivity and blood pressure and restored normal endothelial function. Therefore, the observed endothelial dysfunction is most likely a direct result of hyperandrogenism-induced reductions in insulin sensitivity, as opposed to weight gain.

scholarly journals Introducing a rat model of prenatal androgen-induced polycystic ovary syndrome in adulthood

2014 ◽  
Vol 99 (5) ◽  
pp. 792-801 ◽  
Author(s):  
Fahimeh Ramezani Tehrani ◽  
Mahsa Noroozzadeh ◽  
Saleh Zahediasl ◽  
Abbas Piryaei ◽  
Fereidoun Azizi
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Rat Model ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Prenatal Androgen

Endothelial relaxation mechanisms and nitrative stress are partly restored by Vitamin D3 therapy in a rat model of polycystic ovary syndrome

Life Sciences ◽  
2013 ◽  
Vol 93 (4) ◽  
pp. 133-138 ◽  
Author(s):  
Gabriella Masszi ◽  
Rita Benko ◽  
Noemi Csibi ◽  
Eszter M. Horvath ◽  
Anna-Maria Tokes ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Vitamin D3 ◽  
Rat Model ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Nitrative Stress
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