High neutrophil‐to‐lymphocyte ratio is a predictor of short‐term survival for patients with recurrent cervical cancer after radiation‐based therapy

2021 ◽  
Author(s):  
Ayumi Taguchi ◽  
Yujiro Nakajima ◽  
Akiko Furusawa ◽  
Yasunori Yoshino ◽  
Maki Takao ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Neutrophil To Lymphocyte Ratio ◽  
Short Term ◽  
Term Survival ◽  
Recurrent Cervical Cancer ◽  
Lymphocyte Ratio ◽  
Short Term Survival

scholarly journals Short term survival of critically ill COVID-19 Egyptian patients on assisted ventilation treated by either Dexamethasone or Tocilizumab

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alaa Rashad ◽  
Sherif Mousa ◽  
Hanaa Nafady-Hego ◽  
Asmaa Nafady ◽  
Hamed Elgendy
Keyword(s):  
Critically Ill ◽  
Cox Regression ◽  
Ferritin Level ◽  
Short Term ◽  
Term Survival ◽  
Cox Regression Analysis ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Dexamethasone Group ◽  
Short Term Survival

AbstractTocilizumab (TCZ) and Dexamethasone are used for the treatment of critically ill COVID-19 patients. We compared the short-term survival of critically ill COVID-19 patients treated with either TCZ or Dexamethasone. 109 critically ill COVID-19 patients randomly assigned to either TCZ therapy (46 patients) or pulse Dexamethasone therapy (63 patients). Age, sex, neutrophil/ lymphocyte ratio, D-dimer, ferritin level, and CT chest pattern were comparable between groups. Kaplan–Meier survival analysis showed better survival in Dexamethasone group compared with TCZ (P = 0.002), patients didn’t need vasopressor at admission (P < 0.0001), patients on non-invasive ventilation compared to patients on mechanical ventilation (P<0.0001 ), and in patients with ground glass pattern in CT chest (P<0.0001 ) compared with those who have consolidation. Cox regression analysis showed that, TCZ therapy (HR = 2.162, 95% CI, 1.144–4.087, P <0.0001) compared with Dexamethasone group, higher neutrophil/Lymphocyte ratio (HR = 2.40, CI, 1.351–4.185, P = 0.003), lower PaO2/FiO2, 2 days after treatment, (HR = 1.147, 95% CI, 1.002–1.624, P < 0.0001) independently predicted higher probability of mortality. Dexamethasone showed better survival in severe COVID-19 compared to TCZ. Considering the risk factors mentioned here is crucial when dealing with severe COVID-19 cases.Clinical trial registration No clinicalTrials.gov: Nal protocol approved by Hospital Authorities, for data collection and for participation in CT04519385 (19/08/2020).

scholarly journals Application of Mixture Cure Models in Determining the Survival of Patients with Cervical Cancer

2021 ◽  
Vol 14 (3) ◽  
Author(s):  
Rasool Gharaaghaji ◽  
Hale Ayatollahi ◽  
Marziye Mohammadpour ◽  
Javid Fereidoni ◽  
Hamid Reza Khalkhali
Keyword(s):  
Cervical Cancer ◽  
Parametric Models ◽  
Sample Population ◽  
Short Term ◽  
Term Survival ◽  
Factors Affecting ◽  
Cure Models ◽  
West Azerbaijan ◽  
Short Term Survival

Background: Cervical cancer is the fourth most common cancer among women and the seventh most common worldwide. Objectives: The present study aimed at investigating the usability of cure models in analyzing patients' survival. Besides, the factors affecting the long-term and short-term survival of the patients were determined, using Weibull, log-logistic, and log-normal models. Methods: The sample population of the study included 109 female patients with cervical cancer referred to Motahhari Hospital of Urmia (West Azerbaijan province) from 2004 to 2015. The cure survival analysis was used to determine the patients' survival. Results: The mean and standard deviation age at diagnosis was 50.1 ± 11.7 years. The patients' age, age at marriage, and the disease relapse were significant in the single-variable model on the long-term survival function of the patients. Moreover, the findings showed that Cured Log Logistic Parametric Model was more suitable for analyzing survival data in West Azerbaijan Province, Iran. The relapse variable was significant for all the parametric models. Conclusions: Given the divided sample population into immune and susceptible groups, the mixture cure models can be used to analyze the long-term and short-term survival of the patients with cervical cancer. Moreover, these models can be used to recognize the factors affecting both groups simultaneously.

Influence of age and shock severity on short-term survival in patients with cardiogenic shock

2021 ◽  
Author(s):  
Jacob C Jentzer ◽  
Benedikt Schrage ◽  
David R Holmes ◽  
Salim Dabboura ◽  
Nandan S Anavekar ◽  
...  
Keyword(s):  
Cardiogenic Shock ◽  
Mayo Clinic ◽  
Older Patients ◽  
Cox Proportional Hazards ◽  
Circulatory Support ◽  
Short Term ◽  
Term Survival ◽  
Risk Of Death ◽  
Coronary Syndrome ◽  
Short Term Survival

Abstract Aims Cardiogenic shock (CS) is associated with poor outcomes in older patients, but it remains unclear if this is due to higher shock severity. We sought to determine the associations between age and shock severity on mortality among patients with CS. Methods and results Patients with a diagnosis of CS from Mayo Clinic (2007–15) and University Clinic Hamburg (2009–17) were subdivided by age. Shock severity was graded using the Society for Cardiovascular Angiography and Intervention (SCAI) shock stages. Predictors of 30-day survival were determined using Cox proportional-hazards analysis. We included 1749 patients (934 from Mayo Clinic and 815 from University Clinic Hamburg), with a mean age of 67.6 ± 14.6 years, including 33.6% females. Acute coronary syndrome was the cause of CS in 54.0%. The distribution of SCAI shock stages was 24.1%; C, 28.0%; D, 33.2%; and E, 14.8%. Older patients had similar overall shock severity, more co-morbidities, worse kidney function, and decreased use of mechanical circulatory support compared to younger patients. Overall 30-day survival was 53.3% and progressively decreased as age or SCAI shock stage increased, with a clear gradient towards lower 30-day survival as a function of increasing age and SCAI shock stage. Progressively older age groups had incrementally lower adjusted 30-day survival than patients aged &lt;50 years. Conclusion Older patients with CS have lower short-term survival, despite similar shock severity, with a high risk of death in older patients with more severe shock. Further research is needed to determine the optimal treatment strategies for older CS patients.

scholarly journals Parenteral Nutrition and Oxidant Load in Neonates

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2631
Author(s):  
Kandeepan Karthigesu ◽  
Robert F. Bertolo ◽  
Robert J. Brown
Keyword(s):  
Parenteral Nutrition ◽  
Storage Temperature ◽  
Oral Feeding ◽  
Published Data ◽  
Short Term ◽  
Antioxidant Defences ◽  
Term Survival ◽  
Nutrient Sources ◽  
Short Term Survival

Neonates with preterm, gastrointestinal dysfunction and very low birth weights are often intolerant to oral feeding. In such infants, the provision of nutrients via parenteral nutrition (PN) becomes necessary for short-term survival, as well as long-term health. However, the elemental nutrients in PN can be a major source of oxidants due to interactions between nutrients, imbalances of anti- and pro-oxidants, and environmental conditions. Moreover, neonates fed PN are at greater risk of oxidative stress, not only from dietary sources, but also because of immature antioxidant defences. Various interventions can lower the oxidant load in PN, including the supplementation of PN with antioxidant vitamins, glutathione, additional arginine and additional cysteine; reduced levels of pro-oxidant nutrients such as iron; protection from light and oxygen; and proper storage temperature. This narrative review of published data provides insight to oxidant molecules generated in PN, nutrient sources of oxidants, and measures to minimize oxidant levels.

A registry study on radial head arthroplasties in the Netherlands: Indications, types and short-term survival

2021 ◽  
pp. 175857322098784
Author(s):  
Arno A Macken ◽  
Ante Prkić ◽  
Koen LM Koenraadt ◽  
Iris van Oost ◽  
Anneke Spekenbrink-Spooren ◽  
...  
Keyword(s):  
Radial Head ◽  
Register Data ◽  
Implant Survival ◽  
Short Term ◽  
Term Survival ◽  
Arthroplasty Register ◽  
Common Indication ◽  
Radial Head Arthroplasty ◽  
Kaplan Meier ◽  
Short Term Survival

Background This study aims to use the Dutch Arthroplasty Register data to report an overview of the contemporary indications and implant designs, and report the short-term survival of radial head arthroplasty. Methods From the Dutch Arthroplasty Register, data on patient demographics, surgery and revision were extracted for radial head arthroplasties performed from January 2014 to December 2019. Implant survival was calculated using the Kaplan–Meier method. Results Two hundred fifty-eight arthroplasties were included with a median follow-up of 2.2 years. The most common indication was a fracture of the radial head (178, 69%). One hundred thirty-nine (68%) of the prostheses were of bipolar design, and the most commonly used implant type was the Radial Head System (Tornier; 134, 51%). Of the 258 included radial head arthroplasties, 16 were revised at a median of six months after surgery. Reason for revision was predominantly aseptic loosening (9). The overall implant survival was 95.8% after one year, 90.5% after three years and 89.5% after five years. Discussion For radial head arthroplasties, acute trauma is the most common indication and Radial Head System the most commonly used implant. The implant survival is 89.5% after five years.

Short-term survival, space use and diel patterns of coastal fish species revealed from ‘solo datasets’

2021 ◽  
pp. 1-9
Author(s):  
Gonzalo Mucientes ◽  
Katharina Leeb ◽  
Fiona-Elaine Straßer ◽  
David Villegas-Ríos ◽  
Alexandre Alonso-Fernández
Keyword(s):  
Fish Species ◽  
Space Use ◽  
Short Term ◽  
Term Survival ◽  
Coastal Fish ◽  
Diel Patterns ◽  
Survival Space ◽  
Short Term Survival

Prognostic indicators of short-term survival of ineffective airway clearance in children with acute respiratory infection: a longitudinal study

2020 ◽  
Vol 56 (4) ◽  
pp. 376-387
Author(s):  
Lívia Maia Pascoal ◽  
Marcos Venícios de Oliveira Lopes ◽  
Viviane Martins da Silva ◽  
Daniel Bruno Resende Chaves ◽  
Beatriz Amorim Beltrão ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Respiratory Infection ◽  
Acute Respiratory Infection ◽  
Prognostic Indicators ◽  
Short Term ◽  
Term Survival ◽  
Airway Clearance ◽  
Short Term Survival
Sign in / Sign up

Export Citation Format

Share Document