Analysis of clinical factors and reasons that influence the disposition of cryopreserved embryos in Japanese patients with infertility treated in our clinic

2021 ◽  
Vol 47 (4) ◽  
pp. 1425-1432
Author(s):  
Yuko Nakagawa ◽  
Sachie Onogi ◽  
Shi‐Qing Zhang ◽  
Seiko Nishihara ◽  
Masanori Ito ◽  
...  
Keyword(s):  
Japanese Patients ◽  
Clinical Factors ◽  
Cryopreserved Embryos

Analysis of clinical factors influencing bone mineral density in Japanese patients with diabetes

2016 ◽  
Vol 120 ◽  
pp. S142-S143
Author(s):  
Shogo Funakoshi ◽  
Hiroshi Takata ◽  
Seiki Hirano ◽  
Kumiko Yoshimura ◽  
Satoko Ohmi ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Japanese Patients ◽  
Clinical Factors ◽  
Mineral Density ◽  
Factors Influencing ◽  
Patients With Diabetes

Clinical Factors Predicting the Response of Acute Graft-Versus-Host Disease to Corticosteroid Therapy.

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 3046-3046
Author(s):  
Makoto Murata ◽  
Hideki Nakasone ◽  
Junya Kanda ◽  
Takahiko Nakane ◽  
Tatsuo Furukawa ◽  
...  
Keyword(s):  
Stem Cell ◽  
Corticosteroid Therapy ◽  
Acute Gvhd ◽  
Systemic Corticosteroid ◽  
Japanese Patients ◽  
Clinical Factors ◽  
Cell Sources ◽  
Grade Ii ◽  
Probability Of Improvement ◽  
Systemic Corticosteroid Therapy

Abstract Abstract 3046 Systemic corticosteroid therapy is recommended as a first-line treatment for grade II or higher acute graft-versus-host disease (GVHD). Several clinical factors have been reported to be predictive of response to corticosteroid therapy in retrospective studies in which most or all patients received bone marrow transplantation. However, stem cell sources for allogeneic hematopoietic cell transplantation (HCT) dramatically changed with the frequent use of peripheral blood stem cells (PBSCs) and umbilical cord blood (UCB), and no study has compared the response rates of corticosteroid therapy among these stem cell sources. A retrospective study to identify clinical factors affecting the response of grade II-IV acute GVHD to systemic corticosteroid therapy was performed using the national registry data for Japanese patients who received first allogeneic HCT with bone marrow (BM) (n=2004), PBSCs (n=685), and UCB (n=863). Data were analyzed by STATA ver.12 statistical software. This study was approved by the ethical committees of the Nagoya University School of Medicine. Acute GVHD improved in 2259 (63.6%) of the 3552 patients. On multivariate logistic regression analysis, various factors were identified to predict corticosteroid response (Table 1). Interestingly, UCB was significantly associated with a higher probability of improvement, whereas HLA-matched unrelated BM and HLA-mismatched stem cell sources other than UCB were significantly associated with a lower probability of improvement; HLA-matched related PBSC was not significantly different from HLA-matched related BM. The cumulative incidence of non-relapse mortality (NRM) was significantly higher in patients without than with improvement of acute GVHD with corticosteroid therapy (P < 0.0001). On competing risk regression analysis, patients without improvement with corticosteroid therapy were more likely to have NRM than those with improvement [HR, 2.50; 95% CI, 2.18–2.88]. Other factors associated with significantly worse NRM included age 16–49 y and ≥ 50 y (vs. < 16 y), grade III and IV acute GVHD (vs. grade II), and liver involvement of acute GVHD (vs. no involvement). Overall survival (OS) was significantly lower in patients without improvement with corticosteroid therapy than in patients with improvement (29.5% vs. 42.5% at 15y after transplantation) (P < 0.0001). After adjustment by patient age, disease, grade of acute GVHD, and liver involvement of acute GVHD, OS was significantly lower in patients without than in patients with improvement with corticosteroid therapy [HR, 1.63; 95% CI, 1.46–1.81]. The present study demonstrated, for the first time, a higher probability of improvement in grade II-IV acute GVHD with systemic corticosteroid therapy in patients after UCB transplantation than in those after BM and PBSC transplantation. This finding should be considered in the design of future clinical trials of acute GVHD treatment. The response rate to corticosteroid therapy in Japanese patients (63.6%) was comparable to that in Caucasian patients (50–60%) and, when it is ineffective, Japanese patients also show high NRM and low OS. Thus, another important message of this study is that the establishment of a second-line treatment for corticosteroid-refractory acute GVHD is required for not only Caucasian patients but also for Japanese patients. A prospective study to validate the present findings is warranted. Table 1. Factors predicting the response of grade II-IV acute GVHD to systemic corticosteroid therapy Factor Relative risk* (95% CI) P Patient age (y)     <16 1     16–49 1.54 (1.22–1.94) <0.001     ≥50 1.16 (0.91–1.47) 0.239 Stem cell source     HLA-matched related BM 1     HLA-matched related PBSC 0.81 (0.60–1.10) 0.185     HLA-matched unrelated BM 0.59 (0.45–0.78) <0.001     UCB 1.37 (1.01–1.85) <0.041     HLA-mismatched related BM 0.39 (0.26–0.60) <0.001     HLA-mismatched related PBSC 0.43 (0.28–0.64) <0.001     HLA-mismatched unrelated BM 0.60 (0.45–0.81) <0.01 Onset of acute GVHD     ≤day14 1     > day14 1.21 (1.02–1.44) 0.033 Grade of acute GVHD     II 1     III 0.48 (0.39–0.58) <0.001     IV 0.07 (0.05–0.10) <0.001 Liver acute GVHD     No 1     Yes 0.55 (0.45–0.67) <0.001 Gut acute GVHD     No 1     Yes 0.71 (0.59–0.85) <0.001 * Values > 1.0 indicate higher probability of improvement; values < 1.0 indicate lower probability. Disclosures: No relevant conflicts of interest to declare.

Effect of Genetic Polymorphisms on Development of Gout

2013 ◽  
Vol 40 (8) ◽  
pp. 1374-1378 ◽  
Author(s):  
Wako Urano ◽  
Atsuo Taniguchi ◽  
Eisuke Inoue ◽  
Chieko Sekita ◽  
Naomi Ichikawa ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Genetic Factors ◽  
Japanese Patients ◽  
Cumulative Effects ◽  
Clinical Factors ◽  
Risk Alleles ◽  
C Statistic ◽  
Japanese Male ◽  
Male Patients ◽  
The Mean

Objective.To validate the association between genetic polymorphisms and gout in Japanese patients, and to investigate the cumulative effects of multiple genetic factors on the development of gout.Methods.Subjects were 153 Japanese male patients with gout and 532 male controls. The genotypes of 11 polymorphisms in the 10 genes that have been indicated to be associated with serum uric acid levels or gout were determined. The cumulative effects of the genetic polymorphisms were investigated using a weighted genotype risk score (wGRS) based on the number of risk alleles and the OR for gout. A model to discriminate between patients with gout and controls was constructed by incorporating the wGRS and clinical factors. C statistics method was applied to evaluate the capability of the model to discriminate gout patients from controls.Results.Seven polymorphisms were shown to be associated with gout. The mean wGRS was significantly higher in patients with gout (15.2 ± 2.01) compared to controls (13.4 ± 2.10; p < 0.0001). The C statistic for the model using genetic information alone was 0.72, while the C statistic was 0.81 for the full model that incorporated all genetic and clinical factors.Conclusion.Accumulation of multiple genetic factors is associated with the development of gout. A prediction model for gout that incorporates genetic and clinical factors may be useful for identifying individuals who are at risk of gout.

scholarly journals Preoperative clinical factors and visual outcomes following orbital decompression with dysthyroid optic neuropathy

2020 ◽  
Author(s):  
Mizuki Tagami ◽  
Shigeru Honda ◽  
Atsushi Azumi
Keyword(s):  
Visual Acuity ◽  
Optic Neuropathy ◽  
Japanese Patients ◽  
Decompression Surgery ◽  
Orbital Decompression ◽  
Clinical Factors ◽  
Dysthyroid Optic Neuropathy ◽  
Visual Outcomes ◽  
Additional Surgery ◽  
Case Series Study

Abstract Purpose: To investigate preoperative clinical factors and visual outcomes of Japanese patients with dysthyroid optic neuropathy (DON) after urgent orbital decompression. Methods: This retrospective, observational case series study investigated 44 patients who exhibited several preoperative clinical factors that might be associated with the need for urgent orbital decompression due to DON. Additionally, the visual acuity of DON patients was compared between the patients preoperatively and at 1 and 6 months postoperatively. Results: All 44 patients received steroid and with or without radiation therapy, with 27 patients able to avoid undergoing urgent surgery. However, the remaining 17 patients required urgent orbital decompression following a lack of response to the therapy. None of the patients who initially avoided surgery required additional surgery for DON. Factors significantly associated with the need for urgent orbital decompression surgery included: female gender, older age, long disease duration, unilateral significant DON, history of resistance to pulsed steroid therapy, unstable thyroid function, high TRAb(Thyrotrophin receptor antibody )value, poor visual acuity, presence of central diplopia, and presence of corneal problems ( P <0.05 each). The results also showed that postoperative visual outcomes of surgery for DON were acceptable. Conclusion: This study revealed several preoperative clinical factors for DON that appear to be associated with the need for urgent orbital decompression surgery in Japanese patients.

scholarly journals Clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes: A retrospective study

PLoS ONE ◽  
2019 ◽  
Vol 14 (9) ◽  
pp. e0222598 ◽  
Author(s):  
Shoko Tamaki ◽  
Akio Kanazawa ◽  
Junko Sato ◽  
Yoshifumi Tamura ◽  
Takashi Asahara ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Retrospective Study ◽  
Bacterial Translocation ◽  
Japanese Patients ◽  
Clinical Factors ◽  
Factors Associated

scholarly journals Preoperative clinical factors and visual outcomes following orbital decompression with dysthyroid optic neuropathy

2019 ◽  
Author(s):  
Mizuki Tagami ◽  
Shigeru Honda ◽  
Atsushi Azumi
Keyword(s):  
Visual Acuity ◽  
Optic Neuropathy ◽  
Japanese Patients ◽  
Decompression Surgery ◽  
Orbital Decompression ◽  
Clinical Factors ◽  
Dysthyroid Optic Neuropathy ◽  
Visual Outcomes ◽  
Additional Surgery ◽  
Case Series Study

Abstract Purpose: To investigate preoperative clinical factors and visual outcomes of Japanese patients with dysthyroid optic neuropathy (DON) after urgent orbital decompression. Methods: This retrospective, observational case series study investigated 44 patients who exhibited several preoperative clinical factors that might be associated with the need for urgent orbital decompression due to DON. Additionally, the visual acuity of DON patients was compared between the patients preoperatively and at 1 and 6 months postoperatively. Results: All 44 patients received steroid and radiation therapy, with 27 patients able to avoid undergoing urgent surgery. However, the remaining 17 patients required urgent orbital decompression following a lack of response to the therapy. None of the patients who initially avoided surgery required additional surgery for DON. Factors significantly associated with the need for urgent orbital decompression surgery included: female gender, older age, long disease duration, unilateral significant DON, history of resistance to pulsed steroid therapy, unstable thyroid function, poor visual acuity, presence of central diplopia, and presence of corneal problems ( P <0.05 each). The results also showed that postoperative visual outcomes of surgery for DON were acceptable. Conclusion: This study revealed several preoperative clinical factors for DON that appear to be associated with the need for urgent orbital decompression surgery in Japanese patients.

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