Prognostic role of maspin expression in patients with cervical dysplasia and cervical cancer

2020 ◽  
Vol 46 (5) ◽  
pp. 759-764 ◽  
Author(s):  
Esra Isci Bostanci ◽  
Ismail Guler ◽  
Asiye U. Dikmen ◽  
Ozlem Erdem ◽  
Haldun Guner ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cervical Dysplasia ◽  
Prognostic Role ◽  
Maspin Expression

The prognostic role of horizontal and circumferential tumor extent in cervical cancer: Implications for the 2019 FIGO staging system

2020 ◽  
Vol 158 (2) ◽  
pp. 266-272
Author(s):  
Roman E. Zyla ◽  
Lilian T. Gien ◽  
Danielle Vicus ◽  
Ekaterina Olkhov-Mitsel ◽  
Jelena Mirkovic ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Staging System ◽  
Prognostic Role ◽  
Figo Staging ◽  
Tumor Extent

A single-center retrospective analysis to evaluate the prognostic role of lymph node density in patients with lymph node-positive cervical cancer.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e17013-e17013
Author(s):  
Arkadius A. Polasik ◽  
Wolfgang Janni ◽  
Christoph Scholz ◽  
Nikolaus De Gregorio ◽  
Fabienne Schochter ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Retrospective Analysis ◽  
Prognostic Role ◽  
Node Density ◽  
Lymph Node Density ◽  
Lymph Node Positive ◽  
Positive Lymph Nodes

e17013 Background: The aim of this retrospective analysis is to evaluate the prognostic role of lymph node density (LND), i.e. the ratio of positive lymph nodes to the total number of lymph nodes removed during surgery, in nodal-positive cervical cancer patients. Methods: Out of 266 patients with cervical cancer that underwent surgery including lymphonodectomy between 2000 and 2017 at the Department for Gynecology and Obstetrics of the University Hospital Ulm, 86 patients with positive lymph nodes were included in the analysis. According to former study results, patients were divided into two groups with LND < 10% vs. ≥ 10%. Univariable and multivariable cox-regression models (adjusted for age, histological subtype, grading, body mass index, R-status, lymphangiosis, histologically confirmed FIGO-status and chemotherapy) were used to evaluate the association between LND and both overall survival (OS) and disease-free survival (DFS). Results: In the 86 patients, a median of 42 lymph nodes were removed (range 11 – 107), and a median of 2 lymph nodes (range 1 – 25) were found positive. 57 (66.3%) patients had a LND < 10% and 29 (33.7%) patients had a LND ≥ 10%. There was no significant association between LND (≥ 10% vs. < 10%) and OS in both univariable (hazard ratio[HR] 1.49, 95% CI 0.72 – 3.07, p = 0.280) and multivariable survival analysis (HR 1.46, 95% CI 0.64 – 3.32, p = 0.372), respectively. However, LND was significantly associated with DFS in univariable analysis (HR 2.11, 95% CI 1.10 – 4.03, p = 0.024) and was found to be an independent predictor for DFS in adjusted multivariable analysis (HR 2.30, 95% CI 1.08 – 4.91, p = 0.031). Conclusions: LND ≥ 10% in patients with lymph node-positive cervical cancer is associated with a worsened DFS compared to patients with a LND < 10%. Thus, LND may be used as an independent prognostic marker and/or for risk stratification in these patients.

scholarly journals The Role of Chemokines in Cervical Cancers

Medicina ◽  
2021 ◽  
Vol 57 (11) ◽  
pp. 1141
Author(s):  
Fabian Garrido ◽  
Carl Mathis Wild ◽  
Johanna Mittelberger ◽  
Franziska Dobler ◽  
Mariella Schneider ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Progression ◽  
Immune Checkpoint ◽  
Cervical Dysplasia ◽  
Experimental Studies ◽  
Immune Checkpoints ◽  
Clear Understanding ◽  
Cervical Cancers ◽  
Therapy Development

Both clinical-pathological and experimental studies have shown that chemokines play a key role in activating the immune checkpoint modulator in cervical cancer progression and are associated with prognosis in tumor cell proliferation, invasion, angiogenesis, chemoresistance, and immunosuppression. Therefore, a clear understanding of chemokines and immune checkpoint modulators is essential for the treatment of this disease. This review discusses the origins and categories of chemokines and the mechanisms that are responsible for activating immune checkpoints in cervical dysplasia and cancer, chemokines as biomarkers, and therapy development that targets immune checkpoints in cervical cancer research.

Prognostic role of maspin expression in melanoma: probably far from clinical use

2017 ◽  
Vol 71 (1) ◽  
pp. 158-162 ◽  
Author(s):  
Simone Ribero ◽  
Rebecca Senetta ◽  
Simona Osella-Abate ◽  
Maria S Scalzo ◽  
Isabella Castellano ◽  
...  
Keyword(s):  
Clinical Use ◽  
Prognostic Role ◽  
Maspin Expression
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