Bile acid levels and risk of adverse perinatal outcomes in intrahepatic cholestasis of pregnancy: A meta-analysis

2017 ◽  
Vol 43 (9) ◽  
pp. 1411-1420 ◽  
Author(s):  
Donghua Cui ◽  
Yongxing Zhong ◽  
Lin Zhang ◽  
Hechun Du
Keyword(s):  
Bile Acid ◽  
Intrahepatic Cholestasis ◽  
Meta Analysis ◽  
Perinatal Outcomes ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
Adverse Perinatal Outcomes ◽  
Cholestasis Of Pregnancy

scholarly journals Predictors of adverse perinatal outcomes in intrahepatic cholestasis of pregnancy

2019 ◽  
Vol 90 (4) ◽  
pp. 217-222 ◽  
Author(s):  
Samettin Çelik ◽  
Canan S. Çalışkan ◽  
Handan Çelik ◽  
Mehmet Güçlü ◽  
Alper Başbuğ
Keyword(s):  
Intrahepatic Cholestasis ◽  
Perinatal Outcomes ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
Adverse Perinatal Outcomes ◽  
Cholestasis Of Pregnancy

scholarly journals Intrahepatic cholestasis of pregnancy

2021 ◽  
Vol 16 (S3) ◽  
pp. 50-55
Author(s):  
Ana Maria SCUTELNICU ◽  
◽  
Brînduşa Ana CIMPOCA-RAPTIS ◽  
Anca Marina CIOBANU ◽  
Nicolae GICĂ ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Intrahepatic Cholestasis ◽  
Perinatal Outcomes ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
Fetal Asphyxia ◽  
Increased Risk ◽  
Adverse Perinatal Outcomes ◽  
Adverse Pregnancy ◽  
Cholestasis Of Pregnancy ◽  
Meconium Stained Amniotic Fluid

Intrahepatic cholestasis of pregnancy is the most common liver disease during pregnancy. The main features are maternal pruritus, in the absence of a rash, and raised serum bile acids. Intrahepatic cholestasis of pregnancy is associated with an increased risk of adverse perinatal outcomes, including preterm birth, meconium-stained amniotic fluid, fetal asphyxia with neonatal unit admission or even stillbirth. The main treatment option is ursodeoxycholic acid. We review the etiology, diagnosis, adverse pregnancy outcomes, focusing especially on management of this intriguing condition.

scholarly journals Management of Intrahepatic Cholestasis of Pregnancy: Recommendations of the Working Group on Obstetrics and Prenatal Medicine – Section on Maternal Disorders

2021 ◽  
Vol 81 (08) ◽  
pp. 922-939
Author(s):  
Carsten Hagenbeck ◽  
Amr Hamza ◽  
Sven Kehl ◽  
Holger Maul ◽  
Frank Lammert ◽  
...  
Keyword(s):  
Bile Acid ◽  
Intrahepatic Cholestasis ◽  
Perinatal Outcomes ◽  
Fetal Monitoring ◽  
Fetal Outcome ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
Bile Acid Level ◽  
Cardinal Symptom ◽  
Cholestasis Of Pregnancy ◽  
Meconium Stained Amniotic Fluid

AbstractIntrahepatic cholestasis of pregnancy (ICP) is the most common liver disease specific to pregnancy. The cardinal symptom of pruritus and a concomitant elevated level of bile acids in the serum and/or alanine aminotransferase (ALT) are suggestive for the diagnosis. Overall, the maternal prognosis is good. The fetal outcome depends on the bile acid level. ICP is associated with increased risks for adverse perinatal outcomes, including preterm delivery, meconium-stained amniotic fluid, and stillbirth. Acute fetal asphyxia and not chronic uteroplacental dysfunction leads to stillbirth. Therefore, predictive fetal monitoring is not possible. While medication with ursodeoxycholic acid (UDCA) improves pruritus, it has not been shown to affect fetal outcome. The indication for induction of labour depends on bile acid levels and gestational age. There is a high risk of recurrence in subsequent pregnancies.

scholarly journals Early Onset of Intrahepatic Cholestasis of Pregnancy: a Case Report

2021 ◽  
Author(s):  
Maria Cemortan ◽  
Liudmila Stavinskaia ◽  
Irina Sagaidac ◽  
Olga Cernetchi
Keyword(s):  
Pregnancy Outcomes ◽  
Intrahepatic Cholestasis ◽  
Perinatal Outcomes ◽  
Liver Function Tests ◽  
High Rate ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
High Incidence ◽  
Elevated Liver Function Tests ◽  
Adverse Perinatal Outcomes ◽  
Cholestasis Of Pregnancy

Abstract Intrahepatic cholestasis of pregnancy (ICP) is a disorder characterized by pruritus and elevated liver function tests. Associated with a high incidence of adverse perinatal outcomes, ICP requires thorough attention in clinical practice. In addition, there is a high rate of stillbirth in cases of ICP. Women with ICP should be informed of the inability to predict stillbirth. Multi-disciplinary cooperation is critical for managing the condition and ensuring better pregnancy outcomes.

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