Role of inflammation in intrahepatic cholestasis of pregnancy

2016 ◽  
Vol 42 (3) ◽  
pp. 252-257 ◽  
Author(s):  
Ebru Biberoglu ◽  
Ayse Kirbas ◽  
Korkut Daglar ◽  
Ozgur Kara ◽  
Erdem Karabulut ◽  
...  
Keyword(s):  
Intrahepatic Cholestasis ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
Cholestasis Of Pregnancy

Exploring the genetic role of the HLA-DPB1 locus in Chileans with intrahepatic cholestasis of pregnancy

1996 ◽  
Vol 24 (3) ◽  
pp. 320-323 ◽  
Author(s):  
Juan G. Mella ◽  
Elke Roschmann ◽  
Juan C. Glasinovic ◽  
Alejandra Alvarado ◽  
Mirella Scrivanti ◽  
...  
Keyword(s):  
Intrahepatic Cholestasis ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
Cholestasis Of Pregnancy

scholarly journals The Role of Steroid Hormones in the Development of Intrahepatic Cholestasis of Pregnancy

2015 ◽  
pp. S203-S209 ◽  
Author(s):  
A. PAŘÍZEK ◽  
M. DUŠKOVÁ ◽  
L. VÍTEK ◽  
M. ŠRÁMKOVÁ ◽  
M. HILL ◽  
...  
Keyword(s):  
Liver Function ◽  
Bile Acids ◽  
Steroid Hormones ◽  
Intrahepatic Cholestasis ◽  
Point Of View ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
Hepatic Transaminases ◽  
Exogenous Factors ◽  
Cholestasis Of Pregnancy

Intrahepatic cholestasis of pregnancy (ICP) is a disorder of liver function, commonly occurring in the third trimester but sometimes also as soon as the end of the second trimester of pregnancy. Symptoms of this disorder include pruritus, plus abnormal values of bile acids and hepatic transaminases. After birth, symptoms disappear and liver function returns to normal. Though ICP is relatively non-complicated and often symptomatically mild from the point-of-view of the mother, it presents a serious risk to the fetus, making this disease the subject of great interest. The etiology and pathogenesis of ICP is multifactorial and as yet not fully elucidated. Hormonal factors likely play a significant role, along with genetic as well as exogenous factors. Here we summarize the knowledge of changes in steroid hormones and their role in the development of intrahepatic cholestasis of pregnancy. In addition, we consider the role of exogenous factors as possible triggers of steroid hormone changes, the relationship between metabolic steroids and bile acids, as well as the combination of these factors in the development of ICP in predisposed pregnant women.

scholarly journals The role of ABC transporters’ gene polymorphism in the etiology of intrahepatic cholestasis of pregnancy

2018 ◽  
Vol 89 (7) ◽  
pp. 393-397 ◽  
Author(s):  
Krzysztof Piątek ◽  
Grażyna Kurzawińska ◽  
Justyna Magiełda ◽  
Krzysztof Drews ◽  
Magdalena Barlik ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Abc Transporters ◽  
Intrahepatic Cholestasis ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
Cholestasis Of Pregnancy

The Role of Melatonin, IL-8 and IL-10 in Intrahepatic Cholestasis of Pregnancy

2020 ◽  
Author(s):  
Samettin Çelik ◽  
Huri Guve ◽  
Canan Çalışkan ◽  
Sebahattin Çelik
Keyword(s):  
Intrahepatic Cholestasis ◽  
Inflammatory Cytokine ◽  
Elevated Serum ◽  
Interleukin 10 ◽  
Interleukin 8 ◽  
Controlled Study ◽  
Control Group ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
Cholestasis Of Pregnancy

Abstract Introduction Intrahepatic cholestasis of pregnancy is a pregnancy-specific liver disease that usually emerges during the third trimester of pregnancy. It is characterized by itching and elevated serum total bile acid levels, and it may lead to severe fetal complications. This study aimed to investigate the role of interleukin-8, a pro-inflammatory cytokine; interleukin-10, an anti-inflammatory cytokine; and melatonin in intrahepatic cholestasis of pregnancy. Materials and Methods This prospective, case-controlled study was conducted with 51 women with intrahepatic cholestasis of pregnancy (40 mild and 11 severe cases) and 43 healthy pregnant women. Serum interleukin-8, interleukin-10, and melatonin levels were evaluated. Results Melatonin and interleukin -10 were significantly lower in subjects with intrahepatic cholestasis of pregnancy (p=0.001; p=0.001, respectively p<0.05). Interleukin-8 levels were found to be significantly higher in the cholestasis group than control group (p=0.001, p<0.05). Conclusions Because interleukin-8, interleukin-10, and melatonin were found to be significantly correlated with intrahepatic cholestasis of pregnancy, we believe this finding could shed light on the etiology of the disease.

The role of interleukin-17 in intrahepatic cholestasis of pregnancy

2015 ◽  
Vol 29 (6) ◽  
pp. 977-981 ◽  
Author(s):  
Ayse Kirbas ◽  
Ebru Biberoglu ◽  
Ali Ozgur Ersoy ◽  
Asiye Ugras Dikmen ◽  
Cemile Koca ◽  
...  
Keyword(s):  
Intrahepatic Cholestasis ◽  
Interleukin 17 ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
Cholestasis Of Pregnancy
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