Comparison of oxidative status of mouse pre-antral follicles derived from vitrified whole ovarian tissue and vitrified pre-antral follicles in the presence of alpha lipoic acid

2014 ◽  
Vol 40 (6) ◽  
pp. 1680-1688 ◽  
Author(s):  
Sahar Hatami ◽  
Saeed Zavareh ◽  
Mojdeh Salehnia ◽  
Taghi Lashkarbolouki ◽  
Isaac Karimi
Keyword(s):  
Lipoic Acid ◽  
Ovarian Tissue ◽  
Oxidative Status ◽  
Alpha Lipoic Acid ◽  
Antral Follicles

scholarly journals The Protective Effects of Alpha-Lipoic Acid and Coenzyme Q10Combination on Ovarian Ischemia-Reperfusion Injury: An Experimental Study

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Ahmet Ali Tuncer ◽  
Mehmet Fatih Bozkurt ◽  
Tulay Koken ◽  
Nurhan Dogan ◽  
Mine Kanat Pektaş ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Reperfusion Injury ◽  
Lipoic Acid ◽  
Sham Group ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Ovarian Tissue ◽  
Coenzyme Q ◽  
Alpha Lipoic Acid ◽  
Oxide Synthase

Objective. This study aims to evaluate whether alpha-lipoic acid and/or coenzyme Q10can protect the prepubertal ovarian tissue from ischemia-reperfusion injury in an experimental rat model of ovarian torsion.Materials and Methods. Forty-two female preadolescent Wistar-Albino rats were divided into 6 equal groups randomly. The sham group had laparotomy without torsion; the other groups had torsion/detorsion procedure. After undergoing torsion, group 2 received saline, group 3 received olive oil, group 4 received alpha-lipoic acid, group 5 received coenzyme Q10, and group 6 received both alpha-lipoic acid and coenzyme Q10orally. The oxidant-antioxidant statuses of these groups were compared using biochemical measurement of oxidized/reduced glutathione, glutathione peroxidase and malondialdehyde, pathological evaluation of damage and apoptosis within the ovarian tissue, and immunohistochemical assessment of nitric oxide synthase.Results. The left ovaries of the alpha-lipoic acid + coenzyme Q10group had significantly lower apoptosis scores and significantly higher nitric oxide synthase content than the left ovaries of the control groups. The alpha-lipoic acid + coenzyme Q10group had significantly higher glutathione peroxidase levels and serum malondialdehyde concentrations than the sham group.Conclusions. The combination of alpha-lipoic acid and coenzyme Q10has beneficial effects on oxidative stress induced by ischemia-reperfusion injury related to ovarian torsion.

Effect of Catalase or Alpha Lipoic Acid Supplementation in the Vitrification Solution of Ovine Ovarian Tissue

2018 ◽  
Vol 16 (4) ◽  
pp. 258-269 ◽  
Author(s):  
Luciana M. Silva ◽  
Gildas T. Mbemya ◽  
Denise D. Guerreiro ◽  
Danielle Cristina C. Brito ◽  
Nathalie J. Donfack ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
Ovarian Tissue ◽  
Alpha Lipoic Acid ◽  
Acid Supplementation ◽  
Vitrification Solution

Alpha Lipoic Acid Supplementation Improves Ovarian Tissue Vitrification Outcome: An Alternative to Preserve the Ovarian Function of Morada Nova Ewe

2021 ◽  
Author(s):  
Lucy Vanessa Sulca Ñaupas ◽  
Danielle Cristina Calado Brito ◽  
Samara Silva de Souza ◽  
Fabiana Aparecida Santilli Brandão ◽  
Renato Félix da Silva ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
Ovarian Function ◽  
Ovarian Tissue ◽  
Alpha Lipoic Acid ◽  
Acid Supplementation

Effect of the alpha-lipoic acid on apoptosis in HIT-T15 cells induced by high glucose

2010 ◽  
Vol 34 (8) ◽  
pp. S14-S14
Author(s):  
Yi Yang ◽  
Wei‑Ping Wang ◽  
Yi‑Nan Liu ◽  
Ting Guo ◽  
Ping Chen ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
High Glucose ◽  
Alpha Lipoic Acid

Evaluation of dissolution profiles of alpha lipoic acid soft gelatin capsules and tablets

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
A Uzunovic ◽  
S Hadzidedic ◽  
A Elezovic ◽  
S Pilipovic ◽  
A Sapcanin
Keyword(s):  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
Gelatin Capsules ◽  
Soft Gelatin Capsules

Secunder prevention with alpha-lipoic acid and vitamin E in porphyria cutanea tarda patients

2008 ◽  
Vol 46 (05) ◽  
Author(s):  
E Székely ◽  
K Szentmihályi ◽  
M Bor ◽  
Á Pusztai ◽  
T Kurucz ◽  
...  
Keyword(s):  
Vitamin E ◽  
Lipoic Acid ◽  
Porphyria Cutanea Tarda ◽  
Alpha Lipoic Acid

Advanced glycation end product-induced activation of NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cells

Diabetes ◽  
1997 ◽  
Vol 46 (9) ◽  
pp. 1481-1490 ◽  
Author(s):  
A. Bierhaus ◽  
S. Chevion ◽  
M. Chevion ◽  
M. Hofmann ◽  
P. Quehenberger ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
Advanced Glycation ◽  
Advanced Glycation End Product ◽  
Cultured Endothelial Cells ◽  
Nf Kappab

The use of rosuvastatin and alpha lipoic acid in patients with unstable angina

2017 ◽  
Vol 23 (1-2) ◽  
pp. 9-14
Author(s):  
E.H. Zaremba ◽  
◽  
O.V. Smalyukh ◽  
O.V. Zaremba-Fedchyshyn ◽  
O.V. Zaremba ◽  
...  
Keyword(s):  
Unstable Angina ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid

EVALUATION OF THE EFFECT OF CARNOSINE AND ALPHA-LIPOIC ACID ON THE HEMATOLOGICAL PARAMETERS OF WISTAR RATS WITH INDUCED FATTY LIVER DISEASE

2020 ◽  
Author(s):  
Оксана Константиновна Мустафина ◽  
Элеонора Николаевна Трушина ◽  
Николай Александрович Ригер ◽  
Илья Владимирович Аксенов
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Lipoic Acid ◽  
Fatty Liver Disease ◽  
Hematological Parameters ◽  
Biologically Active ◽  
Alpha Lipoic Acid ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease ◽  
Significant Protective Effect

В исследовании установлено, что использование высококалорийного холинодефицитного рациона (ВКХДР) у крыс привело к снижению уровня гемоглобина и эритроцитарных показателей, лейкоцитозу. Не выявлено достоверного влияния ВКХДР на общее количество тромбоцитов и эритроцитов. Добавление в рационы крыс карнозина и альфа-липоевой кислоты не оказало протективного влияния на изменения гематологического статуса в условиях развития НАЖБП. Studies on the effect of minor biologically active substances on the hematological parameters of rats against the background of induced fatty liver dystrophy. The addition of carnosine and alpha-lipoic acid to rat diets did not have a significant protective effect on changes in the hematological status in conditions of non-alcoholic fatty liver disease.

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