Role of single nucleotide polymorphisms in estrogen-metabolizing enzymes and susceptibility to uterine leiomyoma in Han Chinese: A case-control study

2013 ◽  
Vol 40 (4) ◽  
pp. 1077-1084 ◽  
Author(s):  
Yang Shen ◽  
Qian Xu ◽  
Mulan Ren ◽  
Yunlang Cai ◽  
Jie Xu
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Uterine Leiomyoma ◽  
Case Control Study ◽  
Case Control ◽  
Han Chinese ◽  
Nucleotide Polymorphisms ◽  
Metabolizing Enzymes ◽  
Single Nucleotide ◽  
Control Study

scholarly journals Association of IL-10 and IL-10RA single nucleotide polymorphisms with the responsiveness to HBV vaccination in Chinese infants of HBsAg(+)/HBeAg(−) mothers: a nested case–control study

BMJ Open ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. e022334
Author(s):  
Simin Wen ◽  
Yanhua Wu ◽  
Yuchen Pan ◽  
Mengzhuo Cao ◽  
Dan Zhao ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Single Nucleotide Polymorphisms ◽  
Case Control Study ◽  
Case Control ◽  
Han Chinese ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Hbv Vaccination ◽  
Nested Case Control ◽  
Control Study

ObjectivesTo investigate the association of interleukin (IL)-10 and IL-10 receptor A (IL-10RA) single nucleotide polymorphisms with the responsiveness to hepatitis B virus (HBV) vaccination in newborns whose mothers were hepatitis B surface antigen (HBsAg)(+)/hepatitis B e antigen (HBeAg)(–).DesignNested case–control study.SettingChangchun, China.Participants713 infants from a Han Chinese population whose mothers were HBsAg(+)/HBeAg(–) and participated in the prevention of mother-to-child transmission of HBV at the First Hospital of Jilin University from July 2012 to July 2015 were included. Infants were excluded for HBsAg-positive; unstandardised vaccination process; inadequate blood samples; not Han Chinese and failed genotyping.ResultsInfants with artificial feeding pattern were correlated with low responsiveness to HBV vaccination (p=0.009). The GG genotype of IL-10 rs3021094 was correlated with a higher risk of low responsiveness to HBV vaccination (OR 2.80, 95% CI 1.35 to 5.83). No haplotype was found to be correlated with responsiveness to HBV vaccination. No gene–gene interaction was found between IL-10 and IL-10RA.ConclusionsOur study found that IL-10 gene variants were significantly associated with the immune response to the HBV vaccine. Identifying these high-risk infants who born to HBsAg(+)/HBeAg(–) mothers and low responses to hepatitis B vaccination will provide evidence for individualised prevention strategies.

scholarly journals Role of Single Nucleotide Polymorphisms of Mammaglobin-A Gene in Nasal Polyposis: A Case Control Study

2020 ◽  
Vol 18 (1) ◽  
pp. 10-15
Author(s):  
Işılay Öz ◽  
Sibel Özdaş ◽  
Sibel Baştimur ◽  
Talih Özdaş ◽  
Sami Engin Muz ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Nasal Polyposis ◽  
Case Control Study ◽  
Case Control ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Control Study
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