Effect of postoperative administration of inhaled nitric oxide combined with high‐frequency oscillatory ventilation in infants with acute hypoxemic respiratory failure and pulmonary hypertension after congenital heart surgery: A retrospective cohort study

2021 ◽  
Author(s):  
Shu‐Ting Huang ◽  
Yu‐Qing Lei ◽  
Wen‐Peng Xie ◽  
Yi‐Rong Zheng ◽  
Qiang Chen ◽  
...  
Keyword(s):  
High Frequency ◽  
Retrospective Cohort ◽  
Congenital Heart ◽  
Heart Surgery ◽  
Congenital Heart Surgery ◽  
High Frequency Oscillatory Ventilation ◽  
Hypoxemic Respiratory Failure ◽  
Acute Hypoxemic Respiratory Failure ◽  
Postoperative Administration ◽  
High Frequency Oscillatory

scholarly journals Nasal High-Frequency Oscillatory Ventilation vs. Nasal Continuous Positive Airway Pressure as Therapy for Postextubation Respiratory Failure in Infants After Congenital Heart Surgery

2021 ◽  
Vol 9 ◽  
Author(s):  
Hong-Lin Wu ◽  
Yu-Qing Lei ◽  
Wen-Peng Xie ◽  
Qiang Chen ◽  
Yi-Rong Zheng
Keyword(s):  
High Frequency ◽  
Airway Pressure ◽  
Congenital Heart ◽  
Heart Surgery ◽  
Positive Airway Pressure ◽  
Oxygenation Index ◽  
Congenital Heart Surgery ◽  
High Frequency Oscillatory Ventilation ◽  
Nasal Trauma ◽  
High Frequency Oscillatory

Objective: This study aimed to evaluate the effects of nasal high-frequency oscillatory ventilation (NHFOV) vs. nasal continuous positive airway pressure (NCPAP) on postextubation respiratory failure (PRF) in infants after congenital heart surgery (CHS).Method: Eighty infants underwent postoperative invasive mechanical ventilation for more than 12 h and planned extubation. The infants were randomized to undergo either NHFOV or NCPAP after extubation. Primary outcomes were the incidence of PRF and reintubation, the average PaCO2 level, the average oxygenation index (OI), and pulmonary recruitment in the early extubation phase. Secondary outcomes included the NCPAP/NHFOV time, length of hospital stay, treatment intolerance, signs of discomfort, pneumothorax, adverse hemodynamic effects, nasal trauma, and mortality.Results: Except for PaCO2 within 12 after extubation (39.3 ± 5.8 vs. 43.6 ± 7.3 mmHg, p = 0.05), there was no statistically significant difference for any of the primary outcome measure (PRF, reintubation within 12 h after extubation, oxygenation index within 12 h after extubation, or lung volumes on X-ray after extubation) or secondary outcome measures (duration of non-invasive ventilation, duration of hospital stay, ventilation intolerance, signs of discomfort, pneumothorax, nasal trauma, adverse hemodynamic effects, or death prior to discharge), p > 0.1 for each comparison.Conclusion: NHFOV therapy after extubation in infants after CHS was more efficient in improving CO2 cleaning than NCPAP therapy, but there was no difference in other outcomes (PRF, reintubation, oxygenation index, and pulmonary recruitment).

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