scholarly journals Neurocognitive decline in cardiac surgery—Distraction rather than destruction?

2021 ◽  
Author(s):  
Tulio Caldonazo ◽  
Hristo Kirov ◽  
Torsten Doenst
Keyword(s):  
Cardiac Surgery ◽  
Neurocognitive Decline

C reactive protein and inflammatory response associated to neurocognitive decline following cardiac surgery

2006 ◽  
Vol 130 (2) ◽  
pp. 175-176
Author(s):  
B. Ramlawi ◽  
J.L. Rudolph ◽  
S. Mieno ◽  
S. Gautam ◽  
J. Feng ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Inflammatory Response ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Neurocognitive Decline

C-Reactive protein and inflammatory response associated to neurocognitive decline following cardiac surgery

Surgery ◽  
2006 ◽  
Vol 140 (2) ◽  
pp. 221-226 ◽  
Author(s):  
Basel Ramlawi ◽  
James L. Rudolph ◽  
Shigetoshi Mieno ◽  
Jun Feng ◽  
Munir Boodhwani ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Inflammatory Response ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Neurocognitive Decline

scholarly journals Inflammation but not Glycemic Control is Associated with Neurocognitive Decline After Cardiac Surgery

2021 ◽  
Author(s):  
Laura Scrimgeour ◽  
Ian Ikeda ◽  
Nicholas Sellke ◽  
Guangbin Shi ◽  
Jun Feng ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cardiac Surgery ◽  
Blood Glucose ◽  
Glycemic Control ◽  
Transcriptome Analysis ◽  
Neurocognitive Function ◽  
Human Transcriptome ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Neurocognitive Decline

Background: Whether perioperative glycemic control or markers of inflammation is associated with neurocognitive decline (NCD) after cardiac surgery was examined. Methods: Thirty patients undergoing cardiac surgery utilizing cardiopulmonary bypass (CPB) were screened for NCD preoperatively and on post-operative day four (POD4). Serum cytokine levels were measured and human transcriptome analysis was performed on blood samples. Neurocognitive data are presented as a change from baseline to POD4 in a score standardized with respect to age and gender. Results: A decline in neurocognitive function was identified in 73% (22/30) of patients on POD4. Patients with postoperative leukocytosis (WBC ≥ 10.5) had more NCD when compared to their baseline function (p=0.03). Patients with elevated IL-8 levels at 6 hours postoperatively had a significant decline in NCD at POD4 (p=0.04). Surprisingly, TNF-α, IL-1β, IL-2, or IL-6 levels were not associated with NCD (p>0.3 for all). There was no difference in neurocognitive function between patients with elevated HbA1c levels preoperatively (p=0.973) or elevated fasting blood glucose levels the morning of surgery (>126mg/dL, p=0.910), or a higher maximum blood glucose levels during CPB (>180mg/dL, p=0.252), or higher average glucose levels during CPB (>160mg/dL, p=0.639). Human transcriptome analysis demonstrated unique and differential patterns of gene expression in patients depending on the presence of DM and NCD. Conclusions: Perioperative glycemic control does not have an effect on NCD soon after cardiac surgery. Postoperative leukocytosis and elevated IL-8 levels are associated with neurocognitive decline. The profile of gene expression was altered in patients with NCD with or without diabetes.

scholarly journals Cerebral Ischemic Lesions on Diffusion-Weighted Imaging Are Associated With Neurocognitive Decline After Cardiac Surgery

Stroke ◽  
2008 ◽  
Vol 39 (5) ◽  
pp. 1427-1433 ◽  
Author(s):  
P. Alan Barber ◽  
Sylvia Hach ◽  
Lynette J. Tippett ◽  
Linda Ross ◽  
Alan F. Merry ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Diffusion Weighted Imaging ◽  
Diffusion Weighted ◽  
Cerebral Ischemic ◽  
Neurocognitive Decline

Mycobacterium chimaera Encephalitis Following Cardiac Surgery: A New Syndrome

2019 ◽  
Author(s):  
Darren Lau ◽  
Ryan Cooper ◽  
Justin Chen ◽  
Valerie L Sim ◽  
Jennifer A McCombe ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Neurocognitive Decline

Abstract We report the cases of 3 patients with fatal, disseminated Mycobacterium chimaera infections following cardiac surgeries. Progressive neurocognitive decline and death were explained by active granulomatous encephalitis, with widespread involvement of other organs. This syndrome is clinically elusive and, thus, may have caused deaths in prior reported series.

Chronic exposure to nicotine does not prevent neurocognitive decline after cardiac surgery

2003 ◽  
Vol 17 (3) ◽  
pp. 341-345 ◽  
Author(s):  
George N Djaiani ◽  
Barbara Phillips-Bute ◽  
James A Blumenthal ◽  
Mark F Newman
Keyword(s):  
Cardiac Surgery ◽  
Chronic Exposure ◽  
Neurocognitive Decline

scholarly journals Lower preoperative hematocrit, longer hospital stay, and neurocognitive decline after cardiac surgery

Surgery ◽  
2020 ◽  
Vol 168 (1) ◽  
pp. 147-154
Author(s):  
Anastassia Y. Gorvitovskaia ◽  
Laura A. Scrimgeour ◽  
Brittany A. Potz ◽  
Nicholas C. Sellke ◽  
Afshin Ehsan ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Hospital Stay ◽  
Neurocognitive Decline
Sign in / Sign up

Export Citation Format

Share Document