scholarly journals Percutaneous mitral valve repair assisted by a catheter‐based circulatory support device in a heart transplant patient

Author(s):  
Gaik Nersesian ◽  
Daniel Lewin ◽  
Felix Schoenrath ◽  
Natalia Solowjowa ◽  
Marian Kukucka ◽  
...  
2017 ◽  
Vol 2017 ◽  
pp. 1-3
Author(s):  
Marie Larcher ◽  
Audey Delas ◽  
Clément Delmas ◽  
Olivier Cointault ◽  
Camille Dambrin ◽  
...  

Acute kidney injury (AKI) is often observed after heart transplantation. In this setting, acute tubular necrosis is the main histological finding on kidneys. We report the unusual pathology found in a kidney from a heart-transplant patient. The patient experienced several hemodynamic insults, massive transfusion, and implantation of a mechanical circulatory-support device before heart transplantation: there was prolonged AKI after transplantation. A kidney biopsy revealed acute tubular necrosis and renal hemosiderosis, which was probably related to the transfusion and to mechanical circulatory-support device-induced intravascular hemolysis. Assessment of iron during resuscitation could have prevented, at least partly, AKI.


Author(s):  
Gaik Nersesian ◽  
Daniel Lewin ◽  
Felix Schoenrath ◽  
Natalia Solowjowa ◽  
Marian Kukucka ◽  
...  

Abstract Systemic infections and chronic graft rejection represent common causes of mortality and morbidity in heart transplant patients. In severe cases, cardiogenic shock (CS) may occur and require hemodynamic stabilization with temporary mechanical circulatory support (tempMCS).1 Under these devastating circumstances, treatment of sequelae of left ventricular dysfunction, such as secondary mitral regurgitation (MR) is challenging, especially when surgical repair is deemed futile. In non-transplant patients, interventional mitral valve repair strategies such as the MitraClip system (Abbott Cardiovascular, Plymouth, MN, USA) have been used to successfully treat secondary MR and allow for weaning from tempMCS.2 We report about the first patient in whom profound cardiogenic shock after heart transplantation was stabilized with tempMCS followed by interventional elimination of secondary MR.


2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
F Meijerink ◽  
J Baan ◽  
B.J Bouma

Abstract Background Tricuspid Regurgitation (TR) is often present in patients with mitral regurgitation (MR) and is associated with increased mortality and morbidity after percutaneous mitral valve repair (PMVR) using the MitraClip (Abbott Vascular). It is unclear to what extent TR is reduced after PMVR and whether the reduction of TR is related to survival and functional outcome. Purpose The aim of this study was to determine (1) the TR course after PMVR and (2) if this was related to survival and clinical outcome. Methods Patients who underwent PMVR and had complete echocardiographic data at baseline and follow-up were included. TR severity was graded as none, mild, moderate or severe (according to current guidelines) and was determined before treatment and at 6-months of follow up. Favorable TR course was defined as improvement of ≥1 grade or ≤ mild TR at 6-months. Clinical endpoints were all-cause mortality during 1-year of follow-up and improvement in New York Heart Association (NYHA) functional class after 6 months. Results A total of 67 patients were included (mean age 76 years, 57% male, 81% NYHA class ≥3 and 69% baseline TR ≥ moderate). Favorable TR course was achieved in 31 patients (46%) (figure 1A). All-cause mortality at 1 year was 7.5%, and was lower in the favorable TR course group (0% vs. 13.9%, p=0.057) (figure 1B). Improvement in NYHA class at 6-months was seen in 45% of patients without vs. 81% of patients with favorable TR course (p=0.01) (figure 1C). Conclusion A favorable TR course is achieved in 46% of PMVR patients and is associated with improved survival and improvement of NYHA class. The relatively high rate of an unfavorable TR course at 6-months, indicates that interventional treatment of the tricuspid valve might benefit these patients. TR course (A) and NYHA improvement (B) Funding Acknowledgement Type of funding source: Other. Main funding source(s): Abbott


2020 ◽  
Vol 21 (1) ◽  
pp. 52-60 ◽  
Author(s):  
Tomás Benito-González ◽  
Rodrigo Estévez-Loureiro ◽  
Pedro A. Villablanca ◽  
Patrizio Armeni ◽  
Ignacio Iglesias-Gárriz ◽  
...  

2012 ◽  
Vol 27 (3) ◽  
pp. 295-298 ◽  
Author(s):  
Salvatore Scandura ◽  
Gian Paolo Ussia ◽  
Anna Caggegi ◽  
Sarah Mangiafico ◽  
Valeria Cammalleri ◽  
...  

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