scholarly journals Hepatorenal dysfunction predicts operative mortality after triple valve surgery: Utility of MELD‐Na

Author(s):  
Kevin Lim ◽  
Simon Chi Ying Chow ◽  
Jacky Yan Kit Ho ◽  
Song Wan ◽  
Malcolm John Underwood ◽  
...  
Author(s):  
Kevin Lim ◽  
Chi Ying Simon Chow ◽  
Yan Kit Ho ◽  
Song Wan ◽  
Malcolm Underwood ◽  
...  

Background Despite significant advancements in operative techniques and myocardial protection, triple valve surgery (TVS) remains a formidable operation with a relatively high in-hospital mortality. We evaluated the prognostic value of Model for End-stage Liver Disease score including sodium (MELD-Na) for mortality after TVS and its predictive value when incorporated in the EuroSCORE risk model. Methods We performed a retrospective cohort study of 61 consecutive patients who underwent TVS from November 2005 to June 2016. Demographics, clinical, biochemical, and operative data were collected and analysed. Results Median follow-up duration was 8.0 years. 70.5% of patients suffered from rheumatic heart disease. 86.9% underwent mechanical double valve replacement with tricuspid valve repair. There were six operative deaths (9.84%), with the most common cause of death being multiorgan failure (83.3%). 26.2% had a moderately elevated MELD-Na score of 9 to 15, and 4.9% had a severely elevated score of >15. Patients with a MELD-Na >9 had a higher unadjusted rate of operative mortality, prolonged ventilation, need for dialysis and acute liver failure after TVS. Hierarchical logistic regression was performed using logistic EuroSCORE as the base model. After risk adjustment, each point of MELD-Na score increase was associated with 1.405 times increase in odds of operative mortality. The regression analysis was repeated by incorporating individual components of the MELD-Na score, including bilirubin, sodium, and albumin. All three biochemical parameters were significantly associated with operative mortality Conclusion MELD-Na score as a quantifier of hepatorenal dysfunction is sensitive and specific for mortality after triple valve surgery.


2010 ◽  
Vol 58 (S 01) ◽  
Author(s):  
S Peterss ◽  
N Khaladj ◽  
C Fortmann ◽  
M Shrestha ◽  
I Kutschka ◽  
...  

2013 ◽  
Vol 61 (S 01) ◽  
Author(s):  
PS Risteski ◽  
N Monsefi ◽  
E Srndic ◽  
T Josic ◽  
UA Stock ◽  
...  

Author(s):  
Petar Risteski ◽  
Nadejda Monsefi ◽  
Aleksandra Miskovic ◽  
Tanja Josic ◽  
Sherife Bala ◽  
...  

2006 ◽  
Vol 81 (6) ◽  
pp. 2172-2178 ◽  
Author(s):  
Bahaaldin Alsoufi ◽  
Vivek Rao ◽  
Michael A. Borger ◽  
Manjula Maganti ◽  
Susan Armstrong ◽  
...  

2014 ◽  
Vol 19 (6) ◽  
pp. 978-984 ◽  
Author(s):  
Antonio Lio ◽  
Michele Murzi ◽  
Gioia Di Stefano ◽  
Antonio Miceli ◽  
Enkel Kallushi ◽  
...  

2017 ◽  
Vol 4 (1) ◽  
pp. 1-8
Author(s):  
Yi-Wen B. Liao ◽  
Tom K.M. Wang ◽  
Sophie Harmos ◽  
Tharumenthiran Ramanathan ◽  
Peter Ruygrok

Background: The increasing prevalence of degenerative and functional mitral valve disease as the population ages alongside introduction of percutaneous mitral valve interventions mandates revision of outcomes of mitral valve surgery (MVS) in elderly and high risk patients. We compared the characteristics and outcomes of octogenarians and septuagenarians undergoing MVS. Methods: All patients over 70 years of age having isolated MVS at Auckland City Hospital during 2005-2012 were studied and divided into 70-79 and >80 years age-groups for analysis. Results: There were 20 octogenarians and 81 septuagenarians studied. Apart from median age (82.0 vs. 74.0 years, P<0.001) and previous stroke (15.0% vs. 1.2%, P=0.024) respectively, there were no significant differences in pre-operative characteristics. Octogenarians however had significantly higher median EuroSCORE (4.5% vs. 3.4%, P=0.010) and STS Score (5.6 vs. 2.8%, P=0.002). Despite this, octogenarians had numerically but not statistically significantly less operative mortality (0.0% vs. 7.4%, P=0.340). One, three and five-year survivals were 100.0%, 80.0% and 70.0% for octogenarians and 91.4%, 86.4% and 73.8% septuagenarians. There was also no difference in composite and individual post-operative complications including stroke (P=0.358-1.000). The only independent predictor of operative mortality was cardiopulmonary bypass time odds ratio 1.02, 95% confidence interval 1.00-1.04, P=0.044. Conclusion: Although octogenarians were older with higher risk scores, they did not have increased mortality and morbidity from MVS. MVS remains a safe procedure in selected octogenarians, and other factors beyond age and risk scores such as frailty would be important in deciding the modality of mitral valve intervention in elderly patients.


2017 ◽  
Vol 65 (S 01) ◽  
pp. S1-S110
Author(s):  
G. Färber ◽  
S. Tkebuchava ◽  
C. Sponholz ◽  
M. Diab ◽  
T. Doenst

2013 ◽  
Vol 61 (S 01) ◽  
Author(s):  
T Noack ◽  
J Seeburger ◽  
P Kiefer ◽  
M Vollroth ◽  
M Höbartner ◽  
...  

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