Should sildenafil be started 2 weeks before the operation in ventricular septal defect patients with high pulmonary vascular resistance?

2020 ◽  
Vol 36 (1) ◽  
pp. 422-423
Author(s):  
Ruchit Patel ◽  
Vinay Upadhyay ◽  
Vidur Bansal
Keyword(s):  
Ventricular Septal Defect ◽  
Pulmonary Vascular Resistance ◽  
Vascular Resistance ◽  
Septal Defect ◽  
High Pulmonary Vascular Resistance

Assessment and follow-up of patients with ventricular septal defect and elevated pulmonary vascular resistance

1989 ◽  
Vol 63 (5) ◽  
pp. 327-331 ◽  
Author(s):  
John M. Neutze ◽  
Tatsuo Ishikawa ◽  
Patricia M. Clarkson ◽  
A.Louise Calder ◽  
Brian G. Barratt-Boyes ◽  
...  
Keyword(s):  
Ventricular Septal Defect ◽  
Pulmonary Vascular Resistance ◽  
Vascular Resistance ◽  
Septal Defect

INCREASING PULMONARY VASCULAR RESISTANCE DURING INFANCY IN ASSOCIATION WITH VENTRICULAR SEPTAL DEFECT

PEDIATRICS ◽  
1966 ◽  
Vol 38 (2) ◽  
pp. 220-230 ◽  
Author(s):  
Julien I. E. Hoffman ◽  
Abraham M. Rudolph
Keyword(s):  
Ventricular Septal Defect ◽  
Vascular Disease ◽  
Pulmonary Vascular Resistance ◽  
Vascular Resistance ◽  
Septal Defect ◽  
The Other ◽  
Pulmonary Vascular Disease ◽  
Ventricular Septal Defects ◽  
Septal Defects ◽  
Pulmonary Arterial

Three children with big ventricular septal defects, large pulmonary blood flows, and pulmonary hypertension were catheterized at the ages of 3, 6, and 6 months. Pulmonary vascular resistance was low in two and slightly raised in the other. Recatheterization at the ages of 9, 16, and 26 months, respectively, showed increases of pulmonary vascular resistance in all, and the ventricular septal defects were successfully closed by open-heart operation soon thereafter. In the one child who was recatheterized only after there was clinical evidence of a raised pulmonary vascular resistance, postoperative catheterization showed a progressive rise in pulmonary vascular resistance indicating progressive pulmonary vascular disease. The other two children who were clinically well were recatheterized specifically to try and detect early pulmonary vascular changes and, in contrast, in both of these children pulmonary arterial pressures and vascular resistances have returned to normal after operation. These patients demonstrate that in those at risk of developing pulmonary vascular disease (big ventricular septal defect with high pressures and flows), pulmonary vascular resistance can rise rapidly in early life. In these patients progressive pulmonary vascular disease could be prevented if surgery to lower pulmonary arterial pressure and blood flow is done early enough. Even in patients who appear to be improving, recatheterization is necessary to demonstrate a moderate rise in pulmonary vascular resistance, since a moderate rise is not detectable by current clinical techniques.

Ventricular septal defect with increased pulmonary vascular resistance

1974 ◽  
Vol 33 (3) ◽  
pp. 403-409 ◽  
Author(s):  
Beat Friedli ◽  
B.S. Langford Kidd ◽  
William T. Mustard ◽  
John D. Keith
Keyword(s):  
Ventricular Septal Defect ◽  
Pulmonary Vascular Resistance ◽  
Vascular Resistance ◽  
Septal Defect
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