Gene Therapy for Vein Graft Failure

2013 ◽  
Vol 28 (2) ◽  
pp. 144-147 ◽  
Author(s):  
Xiao-Wen Wang ◽  
Xing-Ji Zhao ◽  
Xiao-Yong Xiang
Keyword(s):  
Gene Therapy ◽  
Vein Graft ◽  
Graft Failure ◽  
Vein Graft Failure

Gene Therapy for Vein Graft Failure Using Tissue Inhibitors of Metalloproteinases

1999 ◽  
Vol 97 (s41) ◽  
pp. 15P-15P
Author(s):  
SJ George ◽  
AH Baker ◽  
GD Angelini ◽  
AC Newby
Keyword(s):  
Gene Therapy ◽  
Vein Graft ◽  
Graft Failure ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Tissue Inhibitors ◽  
Vein Graft Failure

Preventing saphenous vein graft failure: does gene therapy have a role?

2003 ◽  
Vol 76 (3) ◽  
pp. 959-966 ◽  
Author(s):  
Enoch F Akowuah ◽  
Paul J Sheridan ◽  
Graham J Cooper ◽  
Christopher Newman
Keyword(s):  
Gene Therapy ◽  
Saphenous Vein ◽  
Vein Graft ◽  
Graft Failure ◽  
Saphenous Vein Graft ◽  
Vein Graft Failure

Prevention of coronary in-stent restenosis and vein graft failure: Does vascular gene therapy have a role?

2012 ◽  
Vol 136 (1) ◽  
pp. 23-34 ◽  
Author(s):  
Keith E. Robertson ◽  
Robert A. McDonald ◽  
Keith G. Oldroyd ◽  
Stuart A. Nicklin ◽  
Andrew H. Baker
Keyword(s):  
Gene Therapy ◽  
Vein Graft ◽  
Graft Failure ◽  
Stent Restenosis ◽  
Vein Graft Failure ◽  
In Stent Restenosis

scholarly journals Torsion Does Not Affect Early Vein Graft Patency in the Rat Femoral Artery Model

2018 ◽  
Vol 35 (04) ◽  
pp. 299-305
Author(s):  
Amro Harb ◽  
Maxwell Levi ◽  
Akio Kozato ◽  
Yelena Akelina ◽  
Robert Strauch
Keyword(s):  
Vein Graft ◽  
Graft Failure ◽  
Blood Flow Rate ◽  
Graft Patency ◽  
Sprague Dawley ◽  
Rat Models ◽  
Vein Grafts ◽  
Sprague Dawley Rats ◽  
Training Courses ◽  
Vein Graft Failure

Background Torsion of vein grafts is a commonly cited reason for graft failure in clinical setting. Many microsurgery training courses have incorporated vein graft procedures in their curricula, and vein graft torsion is a common technical error made by the surgeons in these courses. To improve our understanding of the clinical reproducibility of practicing vein graft procedures in microsurgery training courses, this study aims to determine if torsion can lead to early vein graft failure in nonsurvival surgery rat models. Methods Sprague-Dawley rats were divided into five cohorts with five rats per cohort for a total of 25 rats. Cohorts were labeled based on degree of vein graft torsion (0, 45, 90, 135, and 180 degrees). Torsion was created in the vein grafts at the distal arterial end by mismatching sutures placed between the proximal end of the vein graft and the distal arterial end. Vein graft patency was then verified 2 and 24 hours postoperation. Results All vein grafts were patent 2 and 24 hours postoperation. At 2 hours, the average blood flow rate measurements for 0, 45, 90, 135, and 180 degrees of torsion were 0.37 ± 0.02, 0.38 ± 0.04, 0.34 ± 0.01, 0.33 ± 0.01, and 0.29 ± 0.02 mL/min, respectively. At 24 hours, they were 0.94 ± 0.07, 1.03 ± 0.15, 1.26 ± 0.22, 1.41 ± 0.11, and 0.89 ± 0.15 mL/min, respectively. Conclusion Torsion of up to 180 degrees does not affect early vein graft patency in rat models. To improve the clinical reproducibility of practicing vein graft procedures in rat models, we suggest that microsurgery instructors assess vein graft torsion prior to clamp release, as vessel torsion does not seem to affect graft patency once the clamps are removed.

About the Impact of Extracardiac Vascular Disease on Vein Graft Failure

2014 ◽  
Vol 98 (5) ◽  
pp. 1889-1890 ◽  
Author(s):  
Ismail Yurekli ◽  
Habib Cakir ◽  
Yuksel Besir ◽  
Orhan Gokalp
Keyword(s):  
Vascular Disease ◽  
Vein Graft ◽  
Graft Failure ◽  
The Impact ◽  
Vein Graft Failure
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