Triggers and decision-making patterns for receiving total knee arthroplasty among older adults with knee osteoarthritis: A qualitative descriptive study

2018 ◽  
Vol 27 (23-24) ◽  
pp. 4373-4380 ◽  
Author(s):  
Kuo-Yao Hsu ◽  
Yun-Fang Tsai ◽  
Wen-Ling Yeh ◽  
Dave W. Chen ◽  
Ching-Yen Chen ◽  
...  
Keyword(s):  
Older Adults ◽  
Decision Making ◽  
Total Knee Arthroplasty ◽  
Knee Osteoarthritis ◽  
Knee Arthroplasty ◽  
Descriptive Study ◽  
Qualitative Descriptive ◽  
Total Knee

Older adults’ postoperative pain medication usage after total knee arthroplasty: A qualitative descriptive study

2012 ◽  
Vol 8 (3) ◽  
pp. 145-152 ◽  
Author(s):  
Samantha Bremner, MSc ◽  
Fiona Webster, PhD ◽  
Joel Katz, PhD ◽  
Judy Watt-Watson, PhD ◽  
Colin McCartney, MBChB
Keyword(s):  
Older Adults ◽  
Total Knee Arthroplasty ◽  
Postoperative Pain ◽  
Knee Arthroplasty ◽  
Descriptive Study ◽  
Pain Medication ◽  
Medication Usage ◽  
Qualitative Descriptive ◽  
Total Knee

Factors related to the indecision of older adults with knee osteoarthritis about receiving physician-recommended total knee arthroplasty

2016 ◽  
Vol 39 (22) ◽  
pp. 2302-2307 ◽  
Author(s):  
Wen-Ling Yeh ◽  
Yun-Fang Tsai ◽  
Kuo-Yao Hsu ◽  
Dave Weichih Chen ◽  
Ching-Yen Chen
Keyword(s):  
Older Adults ◽  
Total Knee Arthroplasty ◽  
Knee Osteoarthritis ◽  
Knee Arthroplasty ◽  
Total Knee

Circulating surgery-induced gene signatures are associated with recovery from total knee arthroplasty for knee osteoarthritis

2021 ◽  
Vol 29 ◽  
pp. S355-S356
Author(s):  
M.A. Kirksey ◽  
S.G. Lessard ◽  
M. Khan ◽  
G.A. Birch ◽  
D. Oliver ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Osteoarthritis ◽  
Knee Arthroplasty ◽  
Gene Signatures ◽  
Total Knee

scholarly journals Age and Sex Differences in Knee Osteoarthritis Patients’ Expectations of Total Knee Arthroplasty

2017 ◽  
Vol 25 ◽  
pp. S346 ◽  
Author(s):  
G.A. Hawker ◽  
D. Marshall ◽  
A. Jones ◽  
L. Woodhouse ◽  
B. Ravi ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Sex Differences ◽  
Knee Osteoarthritis ◽  
Knee Arthroplasty ◽  
Total Knee ◽  
Age And Sex

scholarly journals MAFbx, MuRF1, and the stress-activated protein kinases are upregulated in muscle cells during total knee arthroplasty

2012 ◽  
Vol 303 (4) ◽  
pp. R376-R386 ◽  
Author(s):  
Ashley N. Bailey ◽  
Austin D. Hocker ◽  
Benjamin R. Vermillion ◽  
Keith Smolkowski ◽  
Steven N. Shah ◽  
...  
Keyword(s):  
Older Adults ◽  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Muscle Protein ◽  
Vastus Lateralis ◽  
Cost Effective ◽  
Mrna Levels ◽  
Tourniquet Time ◽  
Total Knee ◽  
Expanding Population

Total knee arthroplasty (TKA) is the most common and a cost-effective surgical remediation for older adults with long-standing osteoarthritis. In parallel with the expanding population of older adults, the number of TKAs performed annually is projected to be 3.48 million by 2030. During this surgery, a tourniquet is used to stop blood flow to the operative leg. However, the molecular pathways that are affected by tourniquet use during TKA continue to be elucidated. We hypothesized that components of the catabolic FoxO3a (i.e., MuRF1, MAFbx, and Bnip3) pathway, as well as the cellular stress pathways [i.e., stress-activated protein kinase (SAPK)/JNK and MAPKs], are upregulated during TKA. The purpose of this study was to measure changes in transcripts and proteins involved in muscle cell catabolic and stress-activated pathways. We obtained muscle biopsies from subjects, 70 ± 1.3 yr, during TKA, from the vastus lateralis at baseline (before tourniquet inflation), during maximal ischemia (just before tourniquet release), and during reperfusion. Total tourniquet time was 43 ± 2 min and reperfusion time was 16 ± 1. Significant increases in FoxO3a downstream targets, MAFbx and MuRF1, were present for mRNA levels during ischemia (MAFbx, P = 0.04; MuRF1, P = 0.04), and protein expression during ischemia (MAFbx, P = 0.002; MuRF1, P = 0.001) and reperfusion (MuRF1, P = 0.002). Additionally, stress-activated JNK gene expression ( P = 0.01) and protein were elevated during ischemia ( P = 0.001). The results of this study support our hypothesis that protein degradation pathways are stimulated during TKA. Muscle protein catabolism is likely to play a role in the rapid loss of muscle volume measured within 2 wk of this surgery.

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