Platelet‐rich plasma in hair loss—Mechanism, preparation, and classification

2021 ◽  
Author(s):  
Sajin Alexander ◽  
Ilse Horo ◽  
Sobha Johnson ◽  
Sheela Daniel
Keyword(s):  
Hair Loss ◽  
Platelet Rich Plasma ◽  
Loss Mechanism

A Split Scalp Study of Single versus Double Spin Platelet-rich plasma Injections in Treatment of Female Pattern Hair Loss: Clinical Effect and Relation to Vascular Endothelial Growth Factor in PRP

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Samar A Salem ◽  
Rania M Elhusseiny ◽  
Haitham M Saleh
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Hair Loss ◽  
Platelet Rich Plasma ◽  
Intradermal Injection ◽  
Vascular Endothelial ◽  
Single Spin ◽  
Double Spin ◽  
Female Pattern Hair Loss ◽  
The Right ◽  
Endothelial Growth Factor

Abstract Background Female pattern hair loss (FPHL) is the most common hair loss disorder in women. Platelet-rich plasma (PRP) provides an option for patients recalcitrant to the currently approved therapies. As there are many methods for the preparation of PRP, the most suitable for AGA therapy is not yet clear. Aims To compare the efficacy between single and double spin PRP injections in treatment of FPHL and to assess the relationship between the concentrations of vascular endothelial growth factor (VEGF) in the PRP preparation and the treatment results obtained. Patients and Methods 15 female patients with FPHL were enrolled. Each patient was subjected to intradermal injection of PRP (prepared by double-spin method) into the right half of the scalp, in addition to intradermal injection of PRP (prepared by singlespin method) into the left half of the scalp in the form of three treatment sessions three weeks apart. Evaluation of treatment response was done through comparing patients' global photographs, assessment of patients' satisfaction and folliscopic assessment before and after treatment. Results Our results showed clinically significant improvement by comparing patients' photographs in most of the treated patients. In addition, folliscopy revealed significant change of the terminal hair density in the right half of the scalp following treatment sessions.VEGF concentration didn't differ significantly between double-spin and single-spin prepared PRP, also it didn't differ significantly upon calcium activation. Conclusions PRP is an effective treatment modality for FPHL. Double-spin prepared PRP could yield better results in the treatment of FPHL than the single-spin method. However, adding Calcium gluconate prior to PRP injection is of no benefit as it didn't significantly increase the release of VEGF. Yet, further studies discussing different PRP preparation protocols and involving a larger number of cases are needed to minimize statistical errors and to detect the most accurate PRP preparation method with the greatest yield of growth factors.

scholarly journals Skin care physicians insight on epidemiological patterns, diagnosis and treatment modalities for female pattern hair loss

2020 ◽  
Vol 7 (1) ◽  
pp. 11
Author(s):  
Krishna Rajesh Kilaru ◽  
Suhasini Attada ◽  
Pooja Munnangi ◽  
Manogna Chowdary Kilaru
Keyword(s):  
Side Effects ◽  
Hair Loss ◽  
Treatment Guidelines ◽  
Age Of Onset ◽  
Platelet Rich Plasma ◽  
Diagnosis And Treatment ◽  
Treatment Modalities ◽  
Common Side Effect ◽  
Medication Cost ◽  
Female Pattern Hair Loss

<p class="abstract"><strong>Background:</strong> Female pattern hair loss (FPHL) is a common cause of hair loss in women characterized by a diffuse reduction in hair density over the crown and frontal scalp with retention of the frontal hairline. The underlying pathophysiology is multifactorial. There are no universally agreed treatment guidelines available. The objective of the study was to understand the diagnosis and treatment pattern of female pattern hair loss and the role of minoxidil topical formulation and its combination in the management of FPHL.</p><p class="abstract"><strong>Methods: </strong>Predesigned questionnaire on FPHL was prepared based on review of literature and was filled by 80 consultant dermatologists. Recorded data was statistically analyzed.</p><p class="abstract"><strong>Results: </strong>Common age of onset of FPHL was between 20 to 30 years. Majority (96.25%) have reported FPHL in association with psychological morbidity. The most preferred treatment in mild and severe FPHL was minoxidil 5% and platelet rich plasma (PRP) plus minoxidil respectively. Most dermatologists (47.5%) treated with minoxidil for over 6 months. Majority (27.5%) reported flaking as the most common side effect with minoxidil followed by dryness, scalp irritation and itching. Majority (27.5%) observed that long treatment duration was contributing to non-compliance followed by medication cost and side effects. Majority of the dermatologists (90%) felt the need for treatment guidelines in the current Indian scenario.</p><p class="abstract"><strong>Conclusions: </strong>Minoxidil was the most common preferred treatment for mild and severe FPHL. PRP is the most common choice of combination therapy with minoxidil. Minimizing side effects, patient education and universal treatment guidelines can help manage FPHL better.  </p>

Platelet rich plasma for the management of hair loss: Better alone or in combination?

2018 ◽  
Vol 18 (2) ◽  
pp. 483-486 ◽  
Author(s):  
Eduardo Anitua ◽  
Ander Pino ◽  
Pedro Jaén ◽  
Mª Rogelia Navarro
Keyword(s):  
Hair Loss ◽  
Platelet Rich Plasma

Platelet-Rich Plasma Hybridized Adipose Transplant (PHAT) for the Treatment of Hair Loss

2022 ◽  
Author(s):  
Rosita Pensato ◽  
Antonio Zaffiro ◽  
Barbara Hersant ◽  
Concetta Errico ◽  
Jean Paul Meningaud ◽  
...  
Keyword(s):  
Hair Loss ◽  
Platelet Rich Plasma

scholarly journals Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil®, Finasteride®, and Adult Stem Cell-Based Therapy

2020 ◽  
Vol 21 (8) ◽  
pp. 2702 ◽  
Author(s):  
Pietro Gentile ◽  
Simone Garcovich
Keyword(s):  
Systematic Review ◽  
Hair Loss ◽  
Platelet Rich Plasma ◽  
Adult Stem Cell ◽  
Lower Grade ◽  
Androgenic Alopecia ◽  
Positive Effects ◽  
Cell Based Therapy ◽  
Local Injections ◽  
Meta Analyses

The number of articles evaluating platelet-rich plasma (PRP) efficacy in androgenic alopecia (AGA) have exponentially increased during the last decade. A systematic review on this field was performed by assessing in the selected studies the local injections of PRP compared to any control for AGA. The protocol was developed in accordance with the Preferred Reporting for Items for Systematic Reviews and Meta-Analyses-Protocols (PRISMA-P) guidelines. A multistep search of the PubMed, MEDLINE, Embase, PreMEDLINE, Ebase, CINAHL, PsycINFO, Clinicaltrials.gov, Scopus database, and Cochrane databases was performed to identify studies on hair loss treatment with platelet-rich plasma. Of the 163 articles initially identified, 123 articles focusing on AGA were selected and, consequently, only 12 clinical trials were analyzed. The studies included had to match predetermined criteria according to the PICOS (patients, intervention, comparator, outcomes, and study design) approach. In total, 84% of the studies reported a positive effect of PRP for AGA treatment. Among them, 50% of the studies demonstrated a statistically significant improvement using objective measures and 34% of the studies showed hair density and hair thickness improvement, although no p values or statistical analysis was described. In total, 17% of the studies reported greater improvement in lower-grade AGA, while 8% noted increased improvement in higher-grade AGA. Only 17% of the studies reported that PRP was not effective in treating AGA. The information analyzed highlights the positive effects of PRP on AGA, without major side effects and thus it be may considered as a safe and effective alternative procedure to treat hair loss compared with Minoxidil® and Finasteride®.

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