A systematic review on the treatment of pediatric severe alopecia areata by topical immunotherapy or Anthralin (contact sensitization) or low‐level light/laser therapy (LLLT): focus on efficacy, safety, treatment duration, recurrence, and follow‐up based on clinical studies

2021 ◽  
Author(s):  
Elham Behrangi ◽  
Masoumeh Roohaninasab ◽  
Afsaneh Sadeghzadeh‐Bazargan ◽  
Niloufar Najar Nobari ◽  
Mohammadreza Ghassemi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Laser Therapy ◽  
Alopecia Areata ◽  
Clinical Studies ◽  
Treatment Duration ◽  
Contact Sensitization ◽  
Low Level ◽  
Topical Immunotherapy

scholarly journals Low-Level Laser Therapy for Temporomandibular Disorders: A Systematic Review with Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Gang-Zhu Xu ◽  
Jie Jia ◽  
Lin Jin ◽  
Jia-Heng Li ◽  
Zhan-Yue Wang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Laser Therapy ◽  
Methodological Quality ◽  
Low Level Laser Therapy ◽  
Low Level ◽  
Low Level Laser ◽  
Jadad Scale ◽  
Level Laser

Objectives. We systematically reviewed randomized controlled trials (RCTs) of the effect of low-level laser therapy (LLLT) versus placebo in patients with temporomandibular disorder (TMD). Methods. A systematic search of multiple online sources electronic databases was undertaken. The methodological quality of each included study was assessed using the modified Jadad scale, and the quality of evidence was evaluated using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system. Results. A total of 31 RCTs were included. Total modified Jadad scale scores showed that the methodological quality was high in 30 studies and low in 1 study. Combining data from all clinically heterogeneous studies revealed positive effects of LLLT on pain relief, regardless of the visual analogue scale (VAS) score or the change of VAS score between the baseline and the final follow-up time point, while dosage analyses showed discrepant results about the effects of high or low doses for patients with TMD. Follow-up analyses showed that LLLT significantly reduced pain at the short-term follow-up. Temporomandibular joint function outcomes indicated that the overall effect favored LLLT over placebo. Conclusion. This systematic review suggests that LLLT effectively relieves pain and improves functional outcomes in patients with TMD.

scholarly journals Low-level laser therapy for temporomandibular disorders (tmd) treatment: a systematic review of randomized trials

2014 ◽  
Vol 2 (5) ◽  
pp. 376
Author(s):  
Priscila Leite ◽  
Nicole Melo ◽  
Pâmela Silva ◽  
Robinsom Montenegro ◽  
Paulo Bonan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Temporomandibular Joint ◽  
Laser Therapy ◽  
Diagnostic Criteria ◽  
Temporomandibular Disorders ◽  
Low Level Laser Therapy ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser ◽  
Significant Difference

AIM: Conducting a systematic review of randomized clinical trials focusing on the efficacy of LLLT on pain control in patients with TMD, diagnosed by the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). MATERIAL AND METHODS: Search was performed at PubMed/MEDLINE database with the terms: (1) “Laser AND temporomandibular disorders”; (2) “Laser AND temporomandibular disorders AND RDC/TMD”; (3) “Low-level laser therapy AND temporomandibular disorders”; (4) “Low-level laser therapy AND temporomandibular disorders AND RDC/TMD”; (5) “Low-level laser therapy AND temporomandibular joint dysfuntion syndrome”; (6) “Low-level laser therapy AND temporomandibular joint dysfuntion syndrome AND RDC/TMD”; (7) “Laser AND temporomandibular joint dysfuntion syndrome” (8) “Laser AND RDC/TMD”; (9) “Low-level laser therapy AND RDC/TMD”. Inclusion criteria: articles need to be randomized clinical trial performed in humans; evaluate the effect of LLLT in the treatment of TMD diagnosed by the use of RDC/TMD; published in English or Portuguese in the last 10 years. Protocol studies and pilot studies were excluded. RESULTS: Ten studies were included. The type of laser used was Gallium Aluminum Arsenide (GaAlAs) diode, with exception of 1 paper, which used super pulsed Gallium Arsenide laser. Eight studies reported decreased in pain levels, in two articles there was no statistically significant difference between test and placebo groups. CONCLUSION: In most studies, LLLT was effective in pain remission, but there is no standardization in parameters like wavelength, output power and frequency. Studies with more complex experimental designs, standardized diagnostic criteria for TMD and defined protocols for the use of LLLT are needed to determine its efficacy in the treatment of TMD.

scholarly journals A Systematic Review on Papers That Study on SNPs That Affect SARS-CoV-2 Infection & COVID-19 Severity

2021 ◽  
Author(s):  
Siyeon Suh ◽  
Sol Lee ◽  
Ho Gym ◽  
Sun Ha Jee ◽  
Sanghyuk Yoon ◽  
...  
Keyword(s):  
Systematic Review ◽  
Virus Infection ◽  
Global Health ◽  
Full Text ◽  
Clinical Studies ◽  
Time History ◽  
The World ◽  
History Of ◽  
Severity Of The Disease

Abstract Background:COVID-19, caused by SARS-CoV-2 has become the most threatening issue to all populations around the world. It is directly and indirectly affecting all of us and thus, is a emergence topic dealt in global health. In order to avoid the infection, various studies have been done and still ongoing. Now having over 141 million cases of COVID19 and causing over 3 million deaths around the world, the tendency of infection and degree severity of the disease shown in different groups of people came up as an issue. Here, we reviewed 21 papers on SNPs related to SARS-CoV-2 infection severity and analyzed the results of them.Methods:The PubMed databases were searched for papers discussing SNPs associated with SARS-CoV-2 infection severity. Clinical studies with human patients and statistically showing relevance of the SNP with virus infection were included. Quality Assessment of all papers were done with Newcastle Ottawa Scale.Results:In the analysis, 21 full-text literatures out of 2956 screened titles and abstracts, including 63496 cases, were included. All were human based clinical studies, some based on certain regions gathered patient data and some based on big databases obtained online. ACE2, TMPRSS2, IFITM3 are the genes mentioned most frequently that are related with SARS-CoV-2 infection. 20 out of 21 studies mentioned one of more of those genes. The relevant genes according to SNPs were also analyzed. rs12252-C, rs143936283, rs2285666, rs41303171, and rs35803318 are the SNPs that were mentioned at least twice in two different studies.Conclusions: We found that ACE2, TMPRSS2, IFITM3 are the major genes that are involved in SARS-CoV-2 infection. The mentioned SNPs were all related to one or more of the above mentioned genes. There were discussions on certain SNPs that increased the infection severity to certain ethinic groups more than the others. However, as there is limited follow up and data due to shortage of time history of the disease, studies may be limited.

Effect of low-level laser therapy on pain and disability in patients with plantar fasciitis: A systematic review and meta-analysis

2021 ◽  
pp. 102478
Author(s):  
Janice S. Guimarães ◽  
Fabio L. Arcanjo ◽  
Gustavo Leporace ◽  
Leonardo F. Metsavaht ◽  
Cristiano Sena ◽  
...  
Keyword(s):  
Systematic Review ◽  
Laser Therapy ◽  
Plantar Fasciitis ◽  
Meta Analysis ◽  
Low Level Laser Therapy ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser
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