Topical antimicrobial peptides in combined treatment of acne patients

2021 ◽  
Author(s):  
Ziyuan Ma ◽  
Nikolay Kochergin ◽  
Olga Olisova ◽  
Elena Snarskaya
Keyword(s):  
Antimicrobial Peptides ◽  
Combined Treatment ◽  
Topical Antimicrobial

scholarly journals ANTIBACTERIAL PEPTIDES IN THE TREATMENT OF ACNE VULGARIS PATIENTS

2019 ◽  
Vol 22 (5-6) ◽  
pp. 185-191
Author(s):  
Ziyuan Ma ◽  
N. G Kochergin
Keyword(s):  
Antimicrobial Peptides ◽  
Regulatory Mechanism ◽  
Acne Vulgaris ◽  
Pathogenic Factors ◽  
Cutibacterium Acnes ◽  
Cellular Immune System ◽  
Proinflammatory Activity ◽  
Cellular Immune ◽  
Topical Antimicrobial ◽  
Positive Results

Acne vulgaris is a multifactorial disease. Besides genomic regulatory mechanism and among numerous triggering factors Cutibacterium acnes is considered as one of the main pathogenic factors, that can activate the human humoral and cellular immune system, exhibiting a robust proinflammatory activity. The article provides an updated review of the data on current antimicrobial peptides that could be used as potential therapeutic agents against microorganisms located in the skin and related to acne disease, which embraces promise to solve the problem of antimicrobial resistance of cutibacterium acnes. The positive results of regular investigation of clinical efficacy of topical antimicrobial peptides GDP-20 in 33 acne vulgaris patients are presented.

Hybrid treatment of multilevel revascularization in patients with peripheral arterial disease – a multi-centre study in Korea

VASA ◽  
2018 ◽  
Vol 47 (3) ◽  
pp. 235-241 ◽  
Author(s):  
Soon Cheon Lee ◽  
Jin Hyun Joh ◽  
Jeong-Hwan Chang ◽  
Hyung-Kee Kim ◽  
Jang Yong Kim ◽  
...  
Keyword(s):  
Endovascular Treatment ◽  
Combined Treatment ◽  
Ankle Brachial Index ◽  
Primary Patency ◽  
Limb Ischaemia ◽  
University Hospitals ◽  
Multi Centre Study ◽  
Free Survival ◽  
Technical Success Rate ◽  
Hybrid Treatment

Abstract. Background: Endovascular treatment is an alternative first-line management for peripheral artery disease (PAD). Hybrid treatment (HT) is defined as a combined treatment for patients with PAD using endovascular and open surgery, simultaneously performed in an operating room. The results of HT are reportedly good for multilevel revascularization (MR) in patients with chronic limb ischaemia, and even in older high-risk patients. The goal of this study was to examine the clinical and haemodynamic outcomes of HT in patients who need MR. Patients and methods: Nine university hospitals in Korea participated in this multicentre study. A total of 134 patients with multilevel PAD underwent HT and MR. Patients were enrolled from July 2014 to June 2015 and were followed for 18 months. Results: The mean age of the patients was 68.8 ± 9.93 years and 88.1 % were men. Patients with Rutherford category 2 to 3 and 4 to 6 comprised 59.0 % and 42.0 % of the group, respectively. The technical success rate was 100 %. The primary patency rates at 12 and 18 months were 77.6 % and 63.9 %, respectively. The primary-assisted patency rates at 12 and 18 months were both 90.0 %. The pre-operative mean ankle brachial index (0.43 ± 0.23) increased to 0.87 ± 0.23 at six months post-operatively (t-test, p < 0.05). The amputation free survival rate was 97.1 %. Conclusions: Although outcomes of multilevel PAD are reportedly poor when endovascular treatment alone is used, we have shown that HT is a feasible alternative modality for patients with multilevel PAD, with satisfactory amputation-free survival and freedom from re-intervention rates.

A Case of Catatonia in a 14-Year-Old Girl with Schizophrenia Treated with Electroconvulsive Therapy

2013 ◽  
Vol 41 (1) ◽  
pp. 69-74 ◽  
Author(s):  
Frank Häßler ◽  
Olaf Reis ◽  
Steffen Weirich ◽  
Jacqueline Höppner ◽  
Birgit Pohl ◽  
...  
Keyword(s):  
Case Report ◽  
Treatment Response ◽  
Electroconvulsive Therapy ◽  
Rating Scale ◽  
Combined Treatment ◽  
Adolescent Patient

This article presents a case of a 14-year-old female twin with schizophrenia who developed severe catatonia following treatment with olanzapine. Under a combined treatment with amantadine, electroconvulsive therapy (ECT), and (currently) ziprasidone alone she improved markedly. Severity and course of catatonia including treatment response were evaluated with the Bush-Francis Catatonia Rating Scale (BFCRS). This case report emphasizes the benefit of ECT in the treatment of catatonic symptoms in an adolescent patient with schizophrenic illness.

Initial evaluation of the effectiveness of individual and group plus individual (combined) treatment

2013 ◽  
Author(s):  
Halley J. Brown ◽  
Lois A. Huebner ◽  
Zac E. Imel ◽  
Alexandra R. Kelly ◽  
Elizabeth Duszak ◽  
...  
Keyword(s):  
Combined Treatment ◽  
Initial Evaluation

Antimicrobial peptides in COPD

Pneumologie ◽  
2009 ◽  
Vol 63 (S 01) ◽  
Author(s):  
G Günther ◽  
E Andresen ◽  
J Bullwinkel ◽  
C Lange ◽  
H Heine
Keyword(s):  
Antimicrobial Peptides
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