scholarly journals Local skin reaction to the AZD1222 vaccine in a patient who survived COVID‐19

2021 ◽  
Author(s):  
Antonella Tammaro ◽  
Ganiyat Adenike Ralitsa Adebanjo ◽  
Francesca Magri ◽  
Francesca Romana Parisella ◽  
Camilla Chello ◽  
...  
Keyword(s):  
Skin Reaction ◽  
Local Skin ◽  
Local Skin Reaction

Post-marketing safety surveillance of tumor treating fields (TTFields) in patients with high-grade glioma in clinical practice.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 2542-2542
Author(s):  
Wenyin Shi ◽  
Deborah T. Blumenthal ◽  
Nancy Ann Oberheim Bush ◽  
Seid Kebir ◽  
Rimas Vincas Lukas ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Brain Tumors ◽  
Elderly Patients ◽  
Skin Reaction ◽  
Anaplastic Astrocytoma ◽  
Phase Iii ◽  
Local Skin ◽  
Tumor Treating Fields ◽  
Safety Surveillance ◽  
Local Skin Reaction

2542 Background: Tumor Treating Fields (TTFields) are an antineoplastic treatment delivering low intensity, intermediate frequency, alternating electric fields through two pairs of transducer arrays locoregionally applied to tumor bed. TTFields are FDA-approved for glioblastoma (GBM; 200 kHz) and mesothelioma (150 kHz). Safety and effectiveness were demonstrated in the phase III EF-11 and EF-14 trials in recurrent GBM (rGBM) and in newly diagnosed GBM (ndGBM), respectively. The main TTFields-related adverse event (AE) was array-associated manageable skin irritation. We report AEs from TTFields-treated patients in the real-world, clinical practice setting. Methods: Unsolicited, global, post-market surveillance data from TTFields-treated patients (October 2011–February 2019) were retrospectively analyzed using MedDRA v21.1, stratified by region (US, EMEA [Europe, Middle East, Africa], or Japan), diagnosis (ndGBM, rGBM, anaplastic astrocytoma and anaplastic oligodendroglioma, or other brain tumors that includes brain metastases from different cancer types), and years of age (<18, pediatric; 18 to 64, adults; or ≥65, elderly). Results: Of 11,029 patients, 53% had ndGBM, 39% had rGBM (at any line of recurrence), 6% had anaplastic astrocytoma/oligodendroglioma, and 1% had other brain tumors. Most were adults (73%) and 26% were elderly (≥65 years of age). The majority of patients were males (66.3%) compared to females (33.7%), with a ratio representative of a typical GBM population. The most reported TTFields-related AE was array-associated local skin reaction, with an incidence of 38% in ndGBM, 29% in rGBM, 38% in anaplastic astrocytoma/oligodendroglioma, 31% in other brain tumors, 37% in pediatric, 34% in adults, and 36% in elderly patients. Most skin AEs were mild to moderate and resolved with no treatment or over the counter topical ointments. Incidence of other TTFields-related AEs in patients with ndGBM and rGBM, respectively, included heat sensation (under-array warmth; 11%, 10%), electric sensation (under-array tingling; 11%, 9%), and headache (7%, 6%). Conclusions: This retrospective, global, TTFields safety surveillance analysis revealed no new safety signals, with favorable safety and tolerability comparable to published TTFields/GBM trials. The most common TTFields-related AE was array-associated local skin reaction. The safety profile remained consistent among subgroups (diagnosis, age, or region) and total cohort, indicating feasibility in multiple subpopulations, including elderly patients.

scholarly journals Exaggerated Delayed Hypersensitivity to Mosquito Bites in Chronic Lymphocytic Leukemia

Blood ◽  
1965 ◽  
Vol 26 (3) ◽  
pp. 257-268 ◽  
Author(s):  
ROBERT I. WEED
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Skin Reaction ◽  
Lymphocytic Leukemia ◽  
Delayed Hypersensitivity ◽  
Local Skin ◽  
Local Skin Reaction ◽  
Cutaneous Hypersensitivity ◽  
Insect Bites ◽  
Delayed Cutaneous Hypersensitivity

Abstract This report has reviewed the clinical histories of 8 patients with chronic lymphocytic leukemia who manifested a marked delayed hypersensitivity type of local skin reaction to insect bites, and mosquito antigen and were capable of reacting normally to other delayed hypersensitivity antigens. We have suggested that this abnormality may represent another example of altered immunologic responsiveness in this disease, consistent with the notion that the lymphocyte is of prime importance for the development of delayed cutaneous hypersensitivity.

scholarly journals Cutaneous and Labyrinthine Tolerance of Bioactive Glass S53P4 in Mastoid and Epitympanic Obliteration Surgery: Prospective Clinical Study

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Daniele Bernardeschi ◽  
Yann Nguyen ◽  
Francesca Yoshie Russo ◽  
Isabelle Mosnier ◽  
Evelyne Ferrary ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Inner Ear ◽  
Round Window ◽  
Bone Conduction ◽  
Hearing Threshold ◽  
Round Window Membrane ◽  
Prospective Clinical Study ◽  
Local Skin ◽  
Local Skin Reaction ◽  
Bone Conduction Hearing

Objective. To evaluate the cutaneous and the inner ear tolerance of bioactive glass S53P4 when used in the mastoid and epitympanic obliteration for chronic otitis surgery.Material and Methods. Forty-one cases have been included in this prospective study. Cutaneous tolerance was clinically evaluated 1 week, 1 month, and 3 months after surgery with a physical examination of the retroauricular and external auditory canal (EAC) skin and the presence of otalgia; the inner ear tolerance was assessed by bone-conduction hearing threshold 1 day after surgery and by the presence of vertigo or imbalance.Results. All surgeries but 1 were uneventful: all patients maintained the preoperative bone-conduction hearing threshold except for one case in which the round window membrane was opened during the dissection of the cholesteatoma in the hypotympanum and this led to a dead ear. No dizziness or vertigo was reported. Three months after surgery, healing was achieved in all cases with a healthy painless skin. No cases of revision surgery for removal of the granules occurred in this study.Conclusion. The bioactive glass S53P4 is a well-tolerated biomaterial for primary or revision chronic otitis surgery, as shown by the local skin reaction which lasted less than 3 months and by the absence of labyrinthine complications.

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