A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low‐potency topical corticosteroid in the treatment of intertrigo

2021 ◽  
Author(s):  
Charussri Leeyaphan ◽  
Supenya Varothai ◽  
Suphattra Trakanwittayarak ◽  
Pranittra Suphatsathienkul ◽  
Suthasinee Pattaravadee ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Topical Corticosteroid ◽  
Controlled Trial ◽  
Aloe Barbadensis ◽  
Tapioca Starch ◽  
Argania Spinosa ◽  
Kernel Oil ◽  
Randomized Controlled ◽  
Butyrospermum Parkii ◽  
Spent Grain

The Comparative Study of Efficacy between Cream Containing Spent Grain Wax, Shea Butter, Argania spinosa Kernel Oil, Tapioca Starch, and 1% Hydrocortisone Cream in The Treatment of Intertrigo

2021 ◽  
Vol 104 (4) ◽  
pp. 565-570
Keyword(s):  
Life Quality ◽  
Shea Butter ◽  
Tapioca Starch ◽  
Argania Spinosa ◽  
Kernel Oil ◽  
Treatment And Prevention ◽  
Significant Difference ◽  
Common Skin ◽  
Spent Grain ◽  
Skin Redness

Background: Intertrigo is a common skin problem. Although there was no standard treatment due to few clinical studies, topical corticosteroids, and drying agents such as talcum are usually used to treat intertrigo, and the side effects of these agents should be monitoring. Objective: To compare the efficacy between cream containing spent grain wax, shea butter, Argania spinosa kernel oil, Tapioca starch, and 1% hydrocortisone cream for the treatment and prevention of intertrigo. Materials and Methods: Fifty-eight lesions from 18 intertrigo patients were randomized into two groups, HCC group, which is the 1% hydrocortisone cream and STIMU-TEX AS group, which is the combination cream of spent grain wax, shea butter, Argania spinosa kernel oil, and tapioca starch. The evaluations were performed at baseline, the first week, the second week, and the fourth week via scoring of skin redness, pruritus, excoriation, Dermatology Life Quality Index (DLQI), and patient satisfaction. The adverse events were also recorded. Results: All participants completed the protocol. At the end of the study, 27 of 29 lesions were completely cured in the HCC group, and 25 of 29 lesions cured in the STIMU-TEX AS group. Although the number of complete remissions of the STIMU-TEX AS group was inferior to the HCC group, it was not statistically significant. There was no relapse within two weeks after completing the treatment. Conclusion: The outcomes showed no statistically significant difference between both groups; thus, the cream may be considered as an alternative treatment and prevention of intertrigo. Keywords: Intertrigo, Spent grain wax, Shea butter, Argania spinosa kernel oil, Tapioca starch

Treatment Fidelity Procedures for an Aphasia Intervention Within a Randomized Controlled Trial: Design, Feasibility, and Results

2020 ◽  
Vol 29 (1S) ◽  
pp. 412-424
Author(s):  
Elissa L. Conlon ◽  
Emily J. Braun ◽  
Edna M. Babbitt ◽  
Leora R. Cherney
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Treatment Protocol ◽  
Treatment Fidelity ◽  
Protocol Adherence ◽  
Study Condition ◽  
Randomized Controlled ◽  
Aphasia Therapy ◽  
Percent Accuracy ◽  
Over Time

Purpose This study reports on the treatment fidelity procedures implemented during a 5-year randomized controlled trial comparing intensive and distributed comprehensive aphasia therapy. Specifically, the results of 1 treatment, verb network strengthening treatment (VNeST), are examined. Method Eight participants were recruited for each of 7 consecutive cohorts for a total of 56 participants. Participants completed 60 hr of aphasia therapy, including 15 hr of VNeST. Two experienced speech-language pathologists delivered the treatment. To promote treatment fidelity, the study team developed a detailed manual of procedures and fidelity checklists, completed role plays to standardize treatment administration, and video-recorded all treatment sessions for review. To assess protocol adherence during treatment delivery, trained research assistants not involved in the treatment reviewed video recordings of a subset of randomly selected VNeST treatment sessions and completed the fidelity checklists. This process was completed for 32 participants representing 2 early cohorts and 2 later cohorts, which allowed for measurement of protocol adherence over time. Percent accuracy of protocol adherence was calculated across clinicians, cohorts, and study condition (intensive vs. distributed therapy). Results The fidelity procedures were sufficient to promote and verify a high level of adherence to the treatment protocol across clinicians, cohorts, and study condition. Conclusion Treatment fidelity strategies and monitoring are feasible when incorporated into the study design. Treatment fidelity monitoring should be completed at regular intervals during the course of a study to ensure that high levels of protocol adherence are maintained over time and across conditions.

Phonomotor Versus Semantic Feature Analysis Treatment for Anomia in 58 Persons With Aphasia: A Randomized Controlled Trial

2019 ◽  
Vol 62 (12) ◽  
pp. 4464-4482 ◽  
Author(s):  
Diane L. Kendall ◽  
Megan Oelke Moldestad ◽  
Wesley Allen ◽  
Janaki Torrence ◽  
Stephen E. Nadeau
Keyword(s):  
Randomized Controlled Trial ◽  
Response Latency ◽  
Controlled Trial ◽  
Semantic Knowledge ◽  
Semantic Feature ◽  
Feature Analysis ◽  
Group Differences ◽  
Randomized Controlled ◽  
Confrontation Naming ◽  
Semantic Feature Analysis

Purpose The ultimate goal of anomia treatment should be to achieve gains in exemplars trained in the therapy session, as well as generalization to untrained exemplars and contexts. The purpose of this study was to test the efficacy of phonomotor treatment, a treatment focusing on enhancement of phonological sequence knowledge, against semantic feature analysis (SFA), a lexical-semantic therapy that focuses on enhancement of semantic knowledge and is well known and commonly used to treat anomia in aphasia. Method In a between-groups randomized controlled trial, 58 persons with aphasia characterized by anomia and phonological dysfunction were randomized to receive 56–60 hr of intensively delivered treatment over 6 weeks with testing pretreatment, posttreatment, and 3 months posttreatment termination. Results There was no significant between-groups difference on the primary outcome measure (untrained nouns phonologically and semantically unrelated to each treatment) at 3 months posttreatment. Significant within-group immediately posttreatment acquisition effects for confrontation naming and response latency were observed for both groups. Treatment-specific generalization effects for confrontation naming were observed for both groups immediately and 3 months posttreatment; a significant decrease in response latency was observed at both time points for the SFA group only. Finally, significant within-group differences on the Comprehensive Aphasia Test–Disability Questionnaire ( Swinburn, Porter, & Howard, 2004 ) were observed both immediately and 3 months posttreatment for the SFA group, and significant within-group differences on the Functional Outcome Questionnaire ( Glueckauf et al., 2003 ) were found for both treatment groups 3 months posttreatment. Discussion Our results are consistent with those of prior studies that have shown that SFA treatment and phonomotor treatment generalize to untrained words that share features (semantic or phonological sequence, respectively) with the training set. However, they show that there is no significant generalization to untrained words that do not share semantic features or phonological sequence features.

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