Role of CYR61 in psoriatic lesional and perilesional skin: A clinical and immunohistochemical study

2021 ◽  
Author(s):  
Wafaa Ahmed Shehata ◽  
Alaa Hassan Maraee ◽  
Eman Essam Abdo ◽  
Aiat Shaban Hemida
Keyword(s):  
Immunohistochemical Study ◽  
Perilesional Skin

scholarly journals CD206+ macrophage is an accelerator of endometriotic-like lesion via promoting angiogenesis in the endometriosis mouse model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yosuke Ono ◽  
Osamu Yoshino ◽  
Takehiro Hiraoka ◽  
Erina Sato ◽  
Akiko Furue ◽  
...  
Keyword(s):  
Mouse Model ◽  
Diphtheria Toxin ◽  
Immunohistochemical Study ◽  
Mrna Levels ◽  
Cytokines And Chemokines ◽  
Diphtheria Toxin Receptor ◽  
Endothelial Cell Marker ◽  
Toxin Receptor ◽  
Group A

AbstractIn endometriosis, M2 MΦs are dominant in endometriotic lesions, but the actual role of M2 MΦ is unclear. CD206 positive (+) MΦ is classified in one of M2 type MΦs and are known to produce cytokines and chemokines. In the present study, we used CD206 diphtheria toxin receptor mice, which enable to deplete CD206+ cells with diphtheria toxin (DT) in an endometriosis mouse model. The depletion of CD206+ MΦ decreased the total weight of endometriotic-like lesions significantly (p < 0.05). In the endometriotic-like lesions in the DT group, a lower proliferation of endometriotic cells and the decrease of angiogenesis were observed. In the lesions, the mRNA levels of VEGFA and TGFβ1, angiogenic factors, in the DT group significantly decreased to approximately 50% and 30% of control, respectively. Immunohistochemical study revealed the expressions of VEGFA and an endothelial cell marker CD31 in lesions of the DT group, were dim compared to those in control. Also, the number of TGFβ1 expressing MΦ was significantly reduced compared to control. These data suggest that CD206+ MΦ promotes the formation of endometriotic-like lesions by inducing angiogenesis around the lesions.

The role of ALK5 in the profile of early reproductive losses in the use of assisted reproductive technologies

2021 ◽  
pp. 70-76
Author(s):  
Abuduwaili Ruziguli ◽  
Nikolai Nikolaevich Rukhliada ◽  
Anna Nikolaevna Taits ◽  
Tatyana Ivanovna Prohorovich ◽  
Tatyana Aleksandrovna Libova
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Embryo Transfer ◽  
Spontaneous Abortion ◽  
Assisted Reproductive Technologies ◽  
Immunohistochemical Study ◽  
Reproductive Technologies ◽  
Decidual Tissue ◽  
Reproductive Losses

This article is devoted to the assessment of the role of ALK5 in the profile of early reproductive losses in the use of assisted reproductive technologies, in particular, by using immunohistochemical study in the group of patients with early spontaneous abortion after the procedure of embryo transfer, a lower level of ALK5 expression in the decidual tissue was revealed (in comparison with control), which may be related to the occurrence of early reproductive losses caused by the imbalance in Th1 / Th2 and its effect on the increase in the concentration of natural killer cells.

Morphostructural and immunohistochemical study on the role of metallothionein in the detoxification of heavy metals inApis melliferaL., 1758

2017 ◽  
Vol 80 (11) ◽  
pp. 1215-1220 ◽  
Author(s):  
Antonio Salvaggio ◽  
Roberta Pecoraro ◽  
Elena Maria Scalisi ◽  
Daniele Tibullo ◽  
Bianca Maria Lombardo ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Immunohistochemical Study

scholarly journals Role of CD8 Cytotoxic T Lymphocytes in Hepatocellular Carcinoma: An Immunohistochemical Study

2019 ◽  
Vol 87 (12) ◽  
pp. 4061-4069
Author(s):  
ASMAA G. ABDOU, M.D.; HALA S. EL-REBEY, M.D. ◽  
NANIS S. HOLAH, M.D.; MERVAT S. SULTAN, M.D. ◽  
SHYMAA H. IBRAHIM, M.Sc.
Keyword(s):  
Hepatocellular Carcinoma ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Immunohistochemical Study
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