Fusidic acid cream comparatively minimizes signs of inflammation and postinflammatory hyperpigmentation after ablative fractional CO 2 laser resurfacing in Chinese patients: A randomized controlled trial

2020 ◽  
Author(s):  
Min Wei ◽  
Li Li ◽  
Xiao Feng Zhang ◽  
Mengna Li ◽  
Baoxi Wang ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Fusidic Acid ◽  
Controlled Trial ◽  
Chinese Patients ◽  
Laser Resurfacing ◽  
Randomized Controlled ◽  
Postinflammatory Hyperpigmentation

Fractional CO2 laser resurfacing for atrophic acne scars: A randomized controlled trial with blinded response evaluation

2012 ◽  
Vol 44 (6) ◽  
pp. 447-452 ◽  
Author(s):  
Lene Hedelund ◽  
Christina S. Haak ◽  
Katrine Togsverd-Bo ◽  
Morten K. Bogh ◽  
Peter Bjerring ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Co2 Laser ◽  
Controlled Trial ◽  
Response Evaluation ◽  
Laser Resurfacing ◽  
Fractional Co2 Laser ◽  
Randomized Controlled ◽  
Acne Scars

scholarly journals Acupuncture to Improve Symptoms for Stable Angina (AIMS-A): Study Protocol for a Randomized Controlled Trial (Preprint)

2019 ◽  
Author(s):  
Judith Schlaeger ◽  
Hui Yan Cai ◽  
Alana D. Steffen ◽  
Veronica Angulo ◽  
Adhir R. Shroff ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Stable Angina ◽  
Controlled Trial ◽  
Treatment Protocol ◽  
Attention Control ◽  
Chinese Patients ◽  
Control Group ◽  
Mcgill Pain Questionnaire ◽  
Analgesic Effects ◽  
Randomized Controlled

BACKGROUND Acupuncture has demonstrated physiologic analgesic effects in Chinese patients with stable angina. One proposed mechanism of action for analgesic effects is the downregulation of M1 macrophages, Interleukin-1β, Interleukin-6, Interleukin-18, and tumor necrosis factor alpha (TNF-α). OBJECTIVE The purpose of this study is to test a 10-session, 5-week acupuncture treatment protocol as a complementary therapy for symptoms of stable angina for American patients, who vary from Chinese patients in healthcare systems and other salient variables. METHODS We are conducting a randomized controlled trial (RCT) of 69 adults (35 assigned to initial acupuncture and 34 to an attention control condition) with a medically confirmed diagnosis of stable angina, whose pain and associated symptoms have not been controlled to their satisfaction with guideline-directed medical management. Participants in the experimental group will receive a standardized Traditional Chinese Medicine (TCM) point prescription. The attention control group will view non-pain-related health education videos over 5 weeks equal to the 10 hours of treatment for the acupuncture group. Participants will complete the McGill Pain Questionnaire and the Seattle Angina Questionnaire-7, as well as have inflammatory cytokines measured at baseline and study completion. Primary outcomes are anginal pain and quality of life. RESULTS Results will be available upon completion of the randomized controlled trial and the analysis of the data. CONCLUSIONS We will generate data on feasibility, acceptability, effect sizes, and protocol revisions for a future fully powered RCT of the protocol. Findings will help determine if patients with persistent ischemic symptoms experience a pro-inflammatory state and/or hyperalgesia caused by multiple neural and immune processes not always relieved with medication. CLINICALTRIAL ClinicalTrials.gov Identifier: NCT02914834

scholarly journals An automated structured education intervention based on a smartphone app in Chinese patients with type 1 diabetes: a protocol for a single-blinded randomized controlled trial

Trials ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Fansu Huang ◽  
Xinyin Wu ◽  
Yuting Xie ◽  
Fang Liu ◽  
Juan Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Randomized Controlled Trial ◽  
Type 1 Diabetes ◽  
Controlled Trial ◽  
Routine Care ◽  
Chinese Patients ◽  
Smartphone App ◽  
Structured Education ◽  
Randomized Controlled

Abstract Background Although evidence had demonstrated the effectiveness of smartphone apps in diabetes care, the majority of apps had been developed for type 2 diabetes mellitus (T2DM) patients and targeted at populations outside of China. The effects of applying a smartphone app with structured education on glycemic control in type 1 diabetes mellitus (T1DM) are unclear. A digital, culturally tailored structured education program was developed in a smartphone app (Yi tang yun qiao) to provide an automated, individualized education program aimed at improving self-management skills in patients with T1DM in China. This trial aims to investigate the effectiveness of this smartphone app among Chinese T1DM patients. Methods and analysis This single-blinded, 24-week, parallel-group randomized controlled trial of a smartphone app versus routine care will be conducted in Changsha, China. We plan to recruit 138 patients with T1DM who will be randomly allocated into the intervention group (automated, individualized education through an app) or routine care group. The intervention will last for 24 weeks. The primary outcome will be the change in glycated hemoglobin (HbA1c) from baseline to week 24. The secondary outcomes will include time in range, fasting blood glucose, levels of serum triglycerides and cholesterol, blood pressure, body mass index, quality of life, diabetes self-care activities, diabetes self-efficacy, depression, anxiety, and patient satisfaction. Adverse events will be formally documented. Data analysis will be conducted using the intention-to-treat principle with appropriate univariate and multivariate methods. Missing data will be imputed with a multiple imputation method under the “missing at random” assumption. Discussion This trial will investigate the effectiveness of an app-based automated structured education intervention for Chinese patients with T1DM. If the intervention is effective, this study will provide a strategy that satisfies the need for effective lifelong diabetes care to reduce the disease burden and related complications resulting from T1DM. Trial registration ClinicalTrials.gov NCT04016987. Registered on 29 October 2019.

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