scholarly journals The effect of hypoxia on the proliferation capacity of dermal papilla cell by regulating lactate dehydrogenase

2020 ◽  
Author(s):  
Jun Ye ◽  
Xiaoli Tang ◽  
Yunzhu Long ◽  
Zhou Chu ◽  
Qing Zhou ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Dermal Papilla ◽  
Dermal Papilla Cell ◽  
Proliferation Capacity

scholarly journals iTRAQ-Based Quantitative Proteomic Comparison of Early- and Late-Passage Human Dermal Papilla Cell Secretome in Relation to Inducing Hair Follicle Regeneration

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0167474 ◽  
Author(s):  
Huan Zhang ◽  
Ning-Xia Zhu ◽  
Keng Huang ◽  
Bo-Zhi Cai ◽  
Yang Zeng ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Dermal Papilla ◽  
Dermal Papilla Cell ◽  
Late Passage

scholarly journals Comparison of Effects on Gene Expression Activity of Low-Molecular-Weight Lychee Fruit Polyphenol (Oligonol®), Adenosine, and Minoxidil in Human Dermal Papilla Cells

2017 ◽  
Vol 3 (1) ◽  
pp. 5 ◽  
Author(s):  
Koji Wakame ◽  
Akifumi Nakata ◽  
Keisuke Sato ◽  
Yoshihiro Mihara ◽  
Jun Takanari ◽  
...  
Keyword(s):  
Cell Lines ◽  
Dna Microarrays ◽  
Food Product ◽  
Dermal Papilla ◽  
Pcr Analysis ◽  
Low Molecular Weight ◽  
Dermal Papilla Cells ◽  
Dermal Papilla Cell ◽  
Expression Of Genes ◽  
Expression Activity

Background: Oligonol® (OLG) is a functional food product and ingredient for cosmetics derived from a lychee fruit polyphenol. It has been reported to act on the skin as an anti-inflammatory and prevent UVB-induced skin damage.Aim: In this study, with the aim of exploring new functionalities of OLG on the scalp, we investigated the effect of OLG on human dermal papilla cells by comparing with adenosine and minoxidil at the genetic level.Method: OLG, adenosine, and minoxidil were applied to human dermal papilla cell lines for 24 h, after which VEGF, FGF-7, WNT5a, and WNT10a mRNA expressions were measured by real-time PCR analysis. Additionally, using DNA microarrays, we investigated the effect on 205 inflammation-related genes.Result: Consequently, in human dermal papilla cell lines, FGF-7 and WNT10a mRNA expression were observed in 100 µg/mL OLG-supplemented cells. The results of the DNA microarray analysis showed that 10 genes were suppressed by OLG.Conclusions: OLG may be expected to affect function of human dermal papilla cell by regulating the expression of genes related to cell proliferation and inflammation.

scholarly journals Characterization of ovine dermal papilla cell aggregation

2016 ◽  
Vol 8 (3) ◽  
pp. 121 ◽  
Author(s):  
AgnesRosarina Prita Sari ◽  
NicholasWolfgang Rufaut ◽  
LeslieNorman Jones ◽  
RodneyDaniel Sinclair
Keyword(s):  
Dermal Papilla ◽  
Cell Aggregation ◽  
Dermal Papilla Cell

Transfection of rat dermal papilla cells with a gene encoding a temperature-sensitive polyomavirus large T antigen generates cell lines retaining a differentiated phenotype

1994 ◽  
Vol 107 (7) ◽  
pp. 1761-1772
Author(s):  
W. Filsell ◽  
J.C. Little ◽  
A.J. Stones ◽  
S.P. Granger ◽  
S.A. Bayley
Keyword(s):  
Cell Lines ◽  
Hair Growth ◽  
Dermal Papilla ◽  
Growth Cycle ◽  
T Antigen ◽  
Temperature Sensitive ◽  
Early Passage ◽  
Gene Encoding ◽  
Dermal Papilla Cells ◽  
Dermal Papilla Cell

The dermal papilla is a discrete group of cells at the base of the hair follicle and is implicated in controlling the hair growth cycle. Early passage dermal papilla cells can induce hair growth in vivo, but, upon further culturing, this property is lost. In order to study the events occurring in hair induction, a representative dermal papilla cell line was required. We have transfected passage 1 rat vibrissa dermal papilla cells with a polyomavirus large T gene encoding a temperature-sensitive T antigen, and generated permanent cell lines in which the immortalizing function can be switched off by temperature shift. The cells established without crisis, resembled cells in the starting population, and retained the aggregative properties of early passage dermal papilla cells. Growth studies were performed on the immortalized cell lines, which showed that transferring the cells to the restrictive temperature for the large T gene product resulted in cell senescence or quiescence, and changes in morphology. Implantation of cell pellets into the ears of immunologically compatible rats showed that the immortal cells retained hair-inductive ability. Cytokines are believed to have an important role in the control of hair growth. The pattern of cytokine gene expression in the immortal cell lines was compared with early passage dermal papilla cells and a non-hair-inducing dermal papilla cell line, using reverse transcriptase-polymerase chain reaction. Epidermal growth factor, tumour necrosis factor, and interleukin-1a were detected in the immortalized and non-hair-inducing dermal papilla cell lines, but were absent in passage 2 dermal papilla cells. All other cytokines examined were detected in all the cell types under study. These results demonstrate that the polyomavirus large Ttsa-immortalized dermal papilla cell lines are very similar to passage 2 dermal papilla cells and thus provide a good model for hair growth studies. Cytokine expression profiles indicate that the expression of several cytokines may be implicated in hair induction. Further studies are under way to investigate the relationship between cytokine expression and the hair growth cycle.

Induction of dermal fibroblasts into dermal papilla cell-like cells in hydrogel microcapsules for enhanced hair follicle regeneration

2020 ◽  
Vol 21 ◽  
pp. 100805
Author(s):  
Bei Xie ◽  
Mengting Chen ◽  
Pinghui Ding ◽  
Lei Lei ◽  
Xing Zhang ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Dermal Papilla ◽  
Dermal Fibroblasts ◽  
Dermal Papilla Cell

scholarly journals Establishment of Rat Dermal Papilla Cell Lines that Sustain the Potency to Induce Hair Follicles from Afollicular Skin

1998 ◽  
Vol 111 (5) ◽  
pp. 767-775 ◽  
Author(s):  
Mutsumi Inamatsu ◽  
Takashi Matsuzaki ◽  
Hiroko Iwanari ◽  
Katsutoshi Yoshizato
Keyword(s):  
Cell Lines ◽  
Dermal Papilla ◽  
Hair Follicles ◽  
Dermal Papilla Cell
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