Potential role of the skin microbiota in Inflammatory skin diseases

2020 ◽  
Author(s):  
Pan Chen ◽  
Guangwen He ◽  
Jingru Qian ◽  
Yi Zhan ◽  
Rong Xiao
Keyword(s):  
Potential Role ◽  
Skin Diseases ◽  
Skin Microbiota ◽  
Inflammatory Skin Diseases ◽  
Inflammatory Skin

scholarly journals Relationship between Skin Microbiota and Skin Biophysical Parameters in Inflammatory Skin Disease: A Systematic Review

2021 ◽  
Vol 7 (1) ◽  
pp. 1-6
Author(s):  
Paola Perugini ◽  
Keyword(s):  
Systematic Review ◽  
Atopic Dermatitis ◽  
Skin Diseases ◽  
Bacterial Flora ◽  
Skin Microbiota ◽  
Biophysical Parameters ◽  
Microbial Composition ◽  
Inflammatory Skin Diseases ◽  
Starting Point ◽  
Inflammatory Skin

Many recent studies highlight the importance of skin microbiota for skin health. Alterations in the balance of bacterial flora cause the development of inflammatory skin diseases such as acne, atopic dermatitis, or psoriasis. This systematic review aims to investigate the relationship, in these skin diseases, between skin microbiota and skin biophysical parameters, such as pH, Transepidermal Water Loss (TEWL), Hydration (HI) and sebum levels. Google Scholar, Medline via Pubmed, and Web of Science were considered as scientific database to search studies about this topic. Research about acne and psoriasis did not produce any results. For this reason, in this review, only articles concerning atopic dermatitis were discussed. Therefore, a possible correlation between skin barrier functionality and microbial composition was also investigated. So, this could be a starting point for the diagnosis of atopic dermatitis or, more generally, for all inflammatory skin diseases.

scholarly journals Features of the Skin Microbiota in Common Inflammatory Skin Diseases

Life ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 962
Author(s):  
Iva Ferček ◽  
Liborija Lugović-Mihić ◽  
Arjana Tambić-Andrašević ◽  
Diana Ćesić ◽  
Ana Gverić Grginić ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Seborrheic Dermatitis ◽  
Bacterial Species ◽  
Clinical Manifestations ◽  
Skin Microbiome ◽  
Bacterial Strains ◽  
Skin Microbiota ◽  
Inflammatory Skin Diseases ◽  
Bacterial Microbiome ◽  
Inflammatory Skin

Many relatively common chronic inflammatory skin diseases manifest on the face (seborrheic dermatitis, rosacea, acne, perioral/periorificial dermatitis, periocular dermatitis, etc.), thereby significantly impairing patient appearance and quality of life. Given the yet unexplained pathogenesis and numerous factors involved, these diseases often present therapeutic challenges. The term “microbiome” comprises the totality of microorganisms (microbiota), their genomes, and environmental factors in a particular environment. Changes in human skin microbiota composition and/or functionality are believed to trigger immune dysregulation, and consequently an inflammatory response, thereby playing a potentially significant role in the clinical manifestations and treatment of these diseases. Although cultivation methods have traditionally been used in studies of bacterial microbiome species, a large number of bacterial strains cannot be grown in the laboratory. Since standard culture-dependent methods detect fewer than 1% of all bacterial species, a metagenomic approach could be used to detect bacteria that cannot be cultivated. The skin microbiome exhibits spatial distribution associated with the microenvironment (sebaceous, moist, and dry areas). However, although disturbance of the skin microbiome can lead to a number of pathological conditions and diseases, it is still not clear whether skin diseases result from change in the microbiome or cause such a change. Thus far, the skin microbiome has been studied in atopic dermatitis, seborrheic dermatitis, psoriasis, acne, and rosacea. Studies on the possible association between changes in the microbiome and their association with skin diseases have improved the understanding of disease development, diagnostics, and therapeutics. The identification of the bacterial markers associated with particular inflammatory skin diseases would significantly accelerate the diagnostics and reduce treatment costs. Microbiota research and determination could facilitate the identification of potential causes of skin diseases that cannot be detected by simpler methods, thereby contributing to the design and development of more effective therapies.

The Role of Chemokines in Inflammatory Skin Diseases

2004 ◽  
pp. 191-225
Author(s):  
G. Girolomoni ◽  
S. Pastore ◽  
A. Cavani ◽  
C. Albanesi
Keyword(s):  
Skin Diseases ◽  
Inflammatory Skin Diseases ◽  
Inflammatory Skin

scholarly journals The Role of the Cutaneous Microbiome in Hidradenitis Suppurativa—Light at the End of the Microbiological Tunnel

2020 ◽  
Vol 21 (4) ◽  
pp. 1205 ◽  
Author(s):  
Langan ◽  
Recke ◽  
Bokor-Billmann ◽  
Billmann ◽  
Kahle ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Treatment Strategies ◽  
Current Treatment ◽  
Acne Inversa ◽  
Inflammatory Skin Diseases ◽  
Microbial Dysbiosis ◽  
Inflammatory Skin ◽  
Personalised Treatment ◽  
Generation Sequencing

The development of next generation sequencing, coupled with advances in bio-informatics, has provided new insights into the role of the cutaneous microbiome in the pathophysiology of a range of inflammatory skin diseases. In fact, it has even been suggested that the identification of specific skin microbial signatures may not only be useful in terms of diagnosis of skin diseases but they may also ultimately help inform personalised treatment strategies. To date, research investigating the role of microbiota in the development of inflammatory skin diseases has largely focused on atopic eczema and psoriasis vulgaris. The role of the microbiome in Hidradenits suppurativa (HS)—also known as acne inversa—a chronic auto-inflammatory skin disease associated with significant morbidity, has received comparatively little attention. This is despite the fact that antimicrobial therapy plays a central role in the treatment of HS. After briefly outlining the clinical features of HS and current treatment strategies, we move on to review the evidence of microbial dysbiosis in HS pathophysiology. We conclude by outlining the potential for metagenomic studies to deepen our understanding of HS biology but more importantly to identify novel and much needed treatment strategies.

Hair eruption initiates and commensal skin microbiota aggravate adverse events of anti-EGFR therapy

2019 ◽  
Vol 11 (522) ◽  
pp. eaax2693 ◽  
Author(s):  
Jörg Klufa ◽  
Thomas Bauer ◽  
Buck Hanson ◽  
Craig Herbold ◽  
Philipp Starkl ◽  
...  
Keyword(s):  
Adverse Events ◽  
Skin Diseases ◽  
De Novo ◽  
Growth Factor Receptor ◽  
Erk Signaling ◽  
Skin Microbiota ◽  
Inflammatory Skin Diseases ◽  
Commensal Microbiota ◽  
Barrier Defect ◽  
Inflammatory Skin

Epidermal growth factor receptor (EGFR)–targeted anticancer therapy induces stigmatizing skin toxicities affecting patients’ quality of life and therapy adherence. The lack of mechanistic details underlying these adverse events hampers their management. We found that EGFR/ERK signaling is required in LRIG1-positive stem cells during de novo hair eruption to secure barrier integrity and prevent the invasion of commensal microbiota and inflammatory skin disease. EGFR-deficient epidermis is permissive for microbiota outgrowth and displays an atopic-like TH2-dominated signature. The opening of the follicular ostia during hair eruption allows invasion of commensal microbiota into the hair follicle, initiating an additional TH1 and TH17 response culminating in chronic folliculitis. Restoration of epidermal ERK signaling via prophylactic FGF7 treatment or transgenic SOS expression rescues the barrier defect in the absence of EGFR, highlighting a therapeutic anchor point. These data reveal that commensal skin microbiota provoke atopic-like inflammatory skin diseases by invading into the follicular opening of erupting hair.

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