Nanostructured lipid carriers incorporating prickly pear seed oil for the encapsulation of vitamin A

2019 ◽  
Vol 18 (6) ◽  
pp. 1875-1884 ◽  
Author(s):  
Sham AlZahabi ◽  
Omar S. Sakr ◽  
Adham A. Ramadan
2018 ◽  
Vol 11 (3) ◽  
pp. 1181-1189 ◽  
Author(s):  
Evelyn Regalado-Rentería ◽  
Juan Rogelio Aguirre-Rivera ◽  
Marco Martín González-Chávez ◽  
Roberto Sánchez-Sánchez ◽  
Fidel Martínez-Gutiérrez ◽  
...  

2011 ◽  
Vol 236-238 ◽  
pp. 1818-1823 ◽  
Author(s):  
Rong Kong ◽  
Qiang Xia ◽  
Guang Yu Liu

Vitamin A Palmitate-loaded Nanostructured Lipid Carriers were prepared by High Pressure Homogenization (HPH) technique. The influences of storage conditions such as time and temperature on the physical and chemical storage stability of VAP-NLCs were studied in details. Preparation and physicochemical properties of VAP lipid nanoparticles were investigated using various analytical equipments such as TEM, photon correlation spectroscopy (PCS), laser diffractometry (LD) and ultraviolet spectrophotometer. The respective optimal HPH pressure and cycles were 70MPa and 5 cycles, so VAP-NLC dispersions under the optimized condition gave rise to the entrapment efficiency (EE) of 99.8%, PI of 0.234, mean diameter of 144±1.7 nm (2% VAP loading capacity). In addition, VAP lipid nanoparticle has a distinct spherical shape, its particle sizes were around 60–330 nm according to VAP contents and zeta potential values -18~-23 mV. Furthermore, the pH of VAP-NLC dispersion was near to 7.0. This study showed that VAP-NLC could hopefully be applied for food products.


2019 ◽  
Vol 96 (2) ◽  
pp. 201-211 ◽  
Author(s):  
Xin Ying Lee ◽  
Chee Chin Chu ◽  
Zafarizal Aldrin Bin Azizul Hasan ◽  
Siaw Kim Chua ◽  
Kar Lin Nyam

2020 ◽  
Vol 8 (6) ◽  
pp. 485-494
Author(s):  
Nazanin Fathi ◽  
Farzaneh Lotfipour ◽  
Solmaz M. Dizaj ◽  
Hamed Hamishehkar ◽  
Maryam Mohammadi

Background: Nanostructured lipid carriers (NLCs), due to their impressive benefits, have recently been considered in different areas. Besides, NLC loaded with essential oils is attractive for finding more effective antimicrobial products, especially against common bacteria such as Staphylococcus epidermidis (S. epidermidis). Objective: This study aims to prepare and characterize NLCs encapsulated with Punica granatum (P. granatum) seed oil (PGS oil-loaded NLCs) and examine the antimicrobial effect of this combination against S. epidermidis. Methods: PGS oil-loaded NLCs were prepared using a hot melt homogenization method. Later, they were characterized by determining particle size distribution (particle size analyzer), morphology (scanning electron microscopy (SEM)), and zeta potential (surface charge of NLCs). Minimum inhibitory concentrations (MIC) of PGS oil-loaded NLCs were assessed and compared with seed oil emulsion of P. granatum against S. epidermidis. Results: PGS oil-loaded NLCs were spherical shaped nanoparticles, with a mean size of 102.10 nm and narrow size distribution (PDI = 0.26). The antibacterial assay showed PGS oil-loaded NLCs to have a higher in vitro antimicrobial activity than seed oil emulsion of P. granatum. Conclusion: To conclude, NLCs may be a favorable carrier to develop new antimicrobial agents. Lay Summary: The lipid nanoparticles such as nanostructured lipid carriers (NLCs) appeared as products first on the cosmetic market. Their advantages help them to be used in different healthcare and cosmetic products. With regard to previous studies, Punica granatum (P. granatum) extract shows antimicrobial and antioxidant properties that could be a valuable natural source against the wide ranges of bacteria. Then, P. granatum seed oil (PGS oil-loaded NLCs) prepared in this study can be used in dental and skin-related materials as a new natural antimicrobial product.


2018 ◽  
Vol 244 ◽  
pp. 83-92 ◽  
Author(s):  
Yasamin Soleimanian ◽  
Sayed Amir Hossein Goli ◽  
Jaleh Varshosaz ◽  
Sayed Mohammad Sahafi

2011 ◽  
Vol 694 ◽  
pp. 365-369 ◽  
Author(s):  
Qiang Xia ◽  
Rong Kong

Vitamin A Palmitate-loaded Nanostructured Lipid Carriers (VAP-NLC) were prepared by High Pressure Homogenization (HPH) technique. Trehalose, glucose, mannitol, α-lactin, D-sorbitol, D-maltose monohydrate and sucrose were chosen as the cryoprotectants. Also, the centrifugal stability of VAP-NLC dispersions after diluting different times and the effects of cryoprotectants on the diameter during the freeze-drying process were investigated extensively. Glucose and α-lactin proved to be the most effective in preventing particles aggregation during the VAP-NLC freeze-drying process. The most suitable concentrations were proved to be 5 wt% and 5 wt%, respectively when the dilution times of VAP-NLC dispersions reached 7 or more before freeze-drying. In conclusion, the NLC formulation demonstrated a promising perspective for oral delivery of poorly water-soluble actives in food industry.


Proceedings ◽  
2021 ◽  
Vol 66 (1) ◽  
pp. 29
Author(s):  
Filomena Nazzaro ◽  
Florinda Fratianni ◽  
Antonio d’Acierno ◽  
Lucia Caputo ◽  
Vincenzo De Feo ◽  
...  

Prickly pear [Opuntia ficus-indica (L.) Mill.] is a succulent plant that is globally diffused. The oil obtained from its seeds has antimicrobial and antioxidant properties. We evaluated the antibiofilm of the oil and its capacity to block the metabolic changes taking place in the microbial cells included in the biofilm. The oil was capable to inhibit at 38.75% the biofilm of Escherichia coli, Pseudomonas aeruginosa, and Pectobacterium carotovorum (38.75%, 71.84%, and 63.06% inhibition, respectively). The metabolic activity of the microbial cells within the biofilm was also strongly inhibited. The action of the prickly pear seeds oil was effective also in blocking at 64.97% the metabolism of Listeria monocytogenes cells.


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