scholarly journals ACE2 and TMPRSS2 in human saliva can adsorb to the oral mucosal epithelium

2021 ◽  
Author(s):  
Fucun Zhu ◽  
Yi Zhong ◽  
Huan Ji ◽  
Ran Ge ◽  
Lu Guo ◽  
...  
Keyword(s):  
Human Saliva ◽  
Mucosal Epithelium

BIOASSAY OF PROLACTIN

1969 ◽  
Vol 60 (1) ◽  
pp. 91-100 ◽  
Author(s):  
Charles S. Nicoll
Keyword(s):  
Epithelial Cells ◽  
Lipid Content ◽  
Dry Weight ◽  
Fat Content ◽  
Assay Sensitivity ◽  
Mucosal Epithelium ◽  
Wet Weight ◽  
Total Dry Weight

ABSTRACT The response of the pigeon crop-sac to systemically acting prolactin (injected subcutaneously) was evaluated by measuring the wet weight of the responsive lateral lobes of the organ and by determining the dry weight of a 4 cm diameter disc of mucosal epithelium taken from one hemicrop. Of several different injection schedules tested, administration of prolactin in four daily injections was found to yield optimal responses. When compared with a graded series of prolactin doses, measurement of the mucosal dry weight proved to be a better method of response quantification than determination of the crop-sac wet weight with respect to both assay sensitivity and precision. The submucosal tissue of the crop-sac was estimated to constitute about 64 % of the total dry weight of the unstimulated organ and it was found to be relatively unresponsive to prolactin stimulation in comparison with the mucosa. The lipid content of the mucosal epithelium was determined using unstimulated crop-sacs or tissues which showed varying degrees of prolactin-induced proliferation. The fat content of the mucosal epithelial cells increased only slightly more rapidly than the dry weight or the defatted dry weight of the mucosa. Suggestions are made for the further improvement of the systemic crop-sac assay for prolactin.

Use of OPLC for quantitation of HCHO, as the dimedone adduct, in human saliva in different dental pathologies

2002 ◽  
Vol 15 (1) ◽  
pp. 19-22 ◽  
Author(s):  
T. Katarzyna Różyło ◽  
Anna Żabińska ◽  
Ingrid Różyło-Kalinowska
Keyword(s):  
Human Saliva

Human Saliva as a Liquid Biopsy for Detecting the SARS-CoV-2

2020 ◽  
Vol 29 (Special Supplement) ◽  
pp. S1-S3
Author(s):  
Zohaib Khurshid ◽  
◽  
Shahjahan Katpar ◽  
Keyword(s):  
Liquid Biopsy ◽  
Human Saliva

Ion Release from Casts of Commercially Pure Titanium in Mixed Solutions of Organic Acids Contained in Human Saliva

2008 ◽  
Vol 52 (4) ◽  
pp. 501-506 ◽  
Author(s):  
Teruhisa Hirayama ◽  
Marie Koike ◽  
Tadafumi Kurogi ◽  
Akiko Shibata ◽  
Shigeru Nakamura ◽  
...  
Keyword(s):  
Organic Acids ◽  
Pure Titanium ◽  
Human Saliva ◽  
Commercially Pure Titanium ◽  
Ion Release ◽  
Commercially Pure ◽  
Mixed Solutions

scholarly journals Human Saliva-Mediated Hydrolysis of Eugenyl-β-D-Glucoside and Fluorescein-di-β-D-Glucoside in In Vivo and In Vitro Models

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 172
Author(s):  
Mariusz Dziadas ◽  
Adam Junka ◽  
Henryk Jeleń
Keyword(s):  
Oral Cavity ◽  
Control Sample ◽  
Rapid Test ◽  
Human Saliva ◽  
In Vitro Models ◽  
Microbial Hydrolysis ◽  
Amoxicillin Trihydrate ◽  
Potassium Clavulanate

Eugenyl-β-D-glucopyranoside, also referred to as Citrusin C, is a natural glucoside found among others in cloves, basil and cinnamon plants. Eugenol in a form of free aglycone is used in perfumeries, flavourings, essential oils and in medicinal products. Synthetic Citrusin C was incubated with human saliva in several in vitro models together with substrate-specific enzyme and antibiotics (clindamycin, ciprofloxacin, amoxicillin trihydrate and potassium clavulanate). Citrusin C was detected using liquid chromatography with tandem mass spectrometry (LC-MS/MS). Citrusin C was completely degraded only when incubated with substrate-specific A. niger glucosidase E.C 3.2.1.21 (control sample) and when incubated with human saliva (tested sample). The addition of antibiotics to the above-described experimental setting, stopped Citrusin C degradation, indicating microbiologic origin of hydrolysis observed. Our results demonstrate that Citrusin C is subjected to complete degradation by salivary/oral cavity microorganisms. Extrapolation of our results allows to state that in the human oral cavity, virtually all β-D-glucosides would follow this type of hydrolysis. Additionally, a new method was developed for an in vivo rapid test of glucosidase activity in the human mouth on the tongue using fluorescein-di-β-D-glucoside as substrate. The results presented in this study serve as a proof of concept for the hypothesis that microbial hydrolysis path of β-D-glucosides begins immediately in the human mouth and releases the aglycone directly into the gastrointestinal tract.

scholarly journals Pentraxin‐3 detected in human saliva shows limited correlation with biomarkers associated with systemic inflammation

Apmis ◽  
2021 ◽  
Author(s):  
Jonas Wetterö ◽  
Frida Jönsson ◽  
Sarah von Löhneysen ◽  
Margareta Kristenson ◽  
Peter Garvin ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Human Saliva ◽  
Pentraxin 3

scholarly journals Survey of Saliva Components and Virus Sensors for Prevention of COVID-19 and Infectious Diseases

Biosensors ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 14
Author(s):  
Priya Dave ◽  
Roberto Rojas-Cessa ◽  
Ziqian Dong ◽  
Vatcharapan Umpaichitra
Keyword(s):  
Infectious Diseases ◽  
Dental Health ◽  
The United States ◽  
Human Saliva ◽  
Field Application ◽  
Future Research ◽  
Prevention Measures ◽  
Control And Prevention ◽  
Close Distance

The United States Centers for Disease Control and Prevention considers saliva contact the lead transmission mean of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the coronavirus disease 2019 (COVID-19). Saliva droplets or aerosols expelled by sneezing, coughing, breathing, and talking may carry this virus. People in close distance may be exposed directly to these droplets or indirectly when touching the droplets that fall on surrounding surfaces and ending up contracting COVID-19 after touching the mucosa tissue of their faces. It is of great interest to quickly and effectively detect the presence of SARS-CoV-2 in an environment, but the existing methods only work in laboratory settings, to the best of our knowledge. However, it may be possible to detect the presence of saliva in the environment and proceed with prevention measures. However, detecting saliva itself has not been documented in the literature. On the other hand, many sensors that detect different organic components in saliva to monitor a person’s health and diagnose different diseases, ranging from diabetes to dental health, have been proposed and they may be used to detect the presence of saliva. This paper surveys sensors that detect organic and inorganic components of human saliva. Humidity sensors are also considered in the detection of saliva because a large portion of saliva is water. Moreover, sensors that detect infectious viruses are also included as they may also be embedded into saliva sensors for a confirmation of the presence of the virus. A classification of sensors by their working principles and the substances they detect is presented, including the sensors’ specifications, sample size, and sensitivity. Indications of which sensors are portable and suitable for field application are presented. This paper also discusses future research and challenges that must be resolved to realize practical saliva sensors. Such sensors may help minimize the spread of not only COVID-19 but also other infectious diseases.

scholarly journals FACTORS INVOLVED IN THE REACTION CHANGES OF HUMAN SALIVA

1927 ◽  
Vol 73 (2) ◽  
pp. 391-404
Author(s):  
Guy W. Clark ◽  
Kenneth L. Carter
Keyword(s):  
Human Saliva
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