scholarly journals Sesamoid bones also show functional adaptation in their microanatomy—The example of the patella in Perissodactyla

2021 ◽  
Author(s):  
Alexandra Houssaye ◽  
Adrien de Perthuis ◽  
Guillaume Houée
Keyword(s):  
Functional Adaptation ◽  
Sesamoid Bones

The Blood Supply to the Canine Palmar Metacarpal Sesamoid Bones

1995 ◽  
Vol 08 (02) ◽  
pp. 76-81 ◽  
Author(s):  
M. A. Cake ◽  
R. A. Read
Keyword(s):  
Blood Supply ◽  
Vascular Supply ◽  
Arterial Supply ◽  
Sesamoid Bones ◽  
Vascular Compromise

SummaryEleven canine forelimbs were examined using either gross dissection or a modified Spalteholz technique to investigate the blood supply of the palmar metacarpal sesamoid bones. In addition, the sesamoid bones, from two prepared skeletons, were examined for the presence of vascular foramina. Multiple vascular foramina were observed over the sesamoid surface. The most consistent elements of the arterial supply were proximal vessels supplying the axial and dorsal abaxial sides of the bone. In addition, palmar and distal sources often made contributions to the blood supply. Various minor or occasional sources were noted. This study demonstrates that the palmar metacarpal sesamoid bones of the dog have an abundant but highly variable vascular supply.The blood supply of the canine palmar metacarpal sesamoid bones was examined, using several methods, in order to evaluate the possible involvement of vascular compromise in sesamoid disease. It was found that the sesamoid bones have an abundant blood supply which is presumably resistant to disruption.

Development of liver-resident CD8 T cells during persistent viral liver infection results in functional adaptation

2020 ◽  
Author(s):  
N Kallin ◽  
M Bosch ◽  
S Donakonda ◽  
K Manske ◽  
D Wohlleber ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Functional Adaptation ◽  
Liver Infection

Republic of Macedonia – Theoretical and Practical Approach to the European Integration

2017 ◽  
Vol 10 (2) ◽  
pp. 293
Author(s):  
Suzana Mehmedi Ph.D ◽  
Ilir Mehmedi Ph.D
Keyword(s):  
European Union ◽  
European Integration ◽  
Political Institutions ◽  
Communicative Action ◽  
Functional Adaptation ◽  
Practical Approach ◽  
The European Union ◽  
Policy Integration ◽  
Basic Premise ◽  
Republic Of Macedonia

The problem of research is very current for several reasons. Namely, the dominant approach on the basis of which are based all have developed and established theories of European integration, developing modern theories of international relations is a realistic basis. Neo-functionalism, inter-guvernmentalism, neo-liberalism, institutionalism (in most of its variants) as the most developed branches of the theory of European integration, despite differences in their settings to keep the basic premise that states are rational, unitary actors, whose interest stems from the assessment of their position in the system of states. For our study caused a special interest model of constructivism using Habermas theory of communicative action according to which entities in mutual interaction is open to other arguments and their validity appreciate having regard to the outgoing reasons and norms on which they are based, thereby seeking consensus as a common goal. Apply to the European Union, this approach allows European institutions were perceived as a place of discussion to reach consensus on solving common problems, rather than just the arena for bargaining. Functional adaptation to the numerous petitions which sets the European Union, requires thorough and integrated activities in the economic, institutional, administrative and legislative spheres. This process should be understood as a continuous, painstaking and long process, not a single radical surgery. Republic of Macedonia, as countries aspiring for membership in the European family must meet the political and economic criteria and to adapt political institutions in the country with those of the European Union and their needs and requirements. The aim of this paper is to perceive the key features and trends in the politics of enlargement and to make a comparison between the policy of expansion applied in the process of accession Central and Eastern Europe and the policy of expansion in the process of stabilization and association, with special emphasis on the Republic of Macedonia. Of course, previously been necessary to develop theoretical and practical approach to the concept of policy integration, development and its major elements and modalities.

Relationship Between Gamma-glutamyl Transpeptidase Activity and Inflammatory Response in Lichen Planus

2018 ◽  
Vol 69 (3) ◽  
pp. 739-743 ◽  
Author(s):  
Madalina Irina Mitran ◽  
Ilinca Nicolae ◽  
Corina Daniela Ene ◽  
Cristina Iulia Mitran ◽  
Clara Matei ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Lichen Planus ◽  
Inflammatory Process ◽  
Molecular Mechanisms ◽  
Functional Adaptation ◽  
Physical Factors ◽  
Inflammatory Disorder ◽  
Gamma Glutamyl Transpeptidase ◽  
Gamma Glutamyl ◽  
Glutamyl Transpeptidase

Chemicals used in the manufacture of synthetic fibers have been associated with undesirable side effects such as itching or skin lesions and it seems that they are involved in the induction of pathological processes such as oxidative stress and inflammation. Lichen planus (LP) can be regarded as an inflammatory disorder, chemical and physical factors playing an important role in the perpetuation of the inflammatory process. Gamma-glutamyl transpeptidase (GGT) plays an important role in the preservation of skin architecture and modulation of skin inflammation. In this study, we found that GGT activity is increased in LP patients with mild inflammation, whilst GGT is inactivated under conditions of severe inflammation. Therefore, GGT is involved in the inflammatory process, but there is no a positive correlation between its activity and the intensity of the inflammatory response. This functional adaptation of the enzyme may be due to down-regulation of its synthesis under free radical overload conditions. Understanding the molecular mechanisms involved in the modulation of intracellular redox homeostasis is an important step in the pharmacological management of patients with LP.

Sex-specific functional adaptation of the femoral diaphysis to body composition

2018 ◽  
Vol 30 (4) ◽  
pp. e23123 ◽  
Author(s):  
Alizé Lacoste Jeanson ◽  
Frédéric Santos ◽  
Ján Dupej ◽  
Jana Velemínská ◽  
Jaroslav Brůžek
Keyword(s):  
Body Composition ◽  
Functional Adaptation ◽  
Femoral Diaphysis

scholarly journals Exercise-mitigated gender-based differences in aging: From genetic alterations to heart performance

2020 ◽  
Author(s):  
Denise Börzsei ◽  
Daniel Priksz ◽  
Renáta Szabó ◽  
Mariann Bombicz ◽  
Zoltán Karácsonyi ◽  
...  
Keyword(s):  
Heart Function ◽  
Protein A ◽  
Genetic Alterations ◽  
Functional Adaptation ◽  
Voluntary Exercise ◽  
Female Rats ◽  
Cell Protein ◽  
Calcium Balance ◽  
Male And Female Rats ◽  
Heart Performance

The prevalence of cardiovascular diseases dramatically increases with age, therefore striving to maintain a physiological heart function became particularly important. We aimed to study the voluntary exercise evoked cardioprotective effects in aged male and female rats, from genetic alterations to changes in heart performance. We divided 20-month-old female and male Wistar rats to control and running groups. After the 12-week-long experimental period, echocardiographic measurements were performed. Afterwards, hearts were either removed for biochemical measurements or mounted into a Langendorff-perfusion system to detect infarct size. The following genes and their proteins were analyzed from heart: catechol-O-methyltransferase (Comt), endothelin-1 (Esm1), Purkinje cell protein-4 (Pcp4), and osteoglycin (Ogn). Recreational exercise caused functional improvements; however, changes were more prominent in males. Cardiac expression of Comt and Ogn were reduced as a result of exercise in aged males, while Pcp4 and Esm1 showed a marked overexpression, along with a markedly improved diastolic function. The key result of this study is that exercise enhanced the expression of the Pcp4 gene and protein, a recently described regulator of calcium balance in cardiomyocytes, and suppressed Comt and Ogn gene expression, that has been associated with impaired cardiac function. In addition, as a result of exercise, a significant improvement was observed in the size of infarct elicited by left anterior descending coronary artery occlusion. Our results clearly show that age and sex-dependent changes were both apparent in key proteins linked to cardiovascular physiology. Exercise-moderated fundamental genetic alterations may have contributed to the functional adaptation of the heart.

Functional Adaptation Skills Training (FAST): A randomized trial of a psychosocial intervention for middle-aged and older patients with chronic psychotic disorders

2006 ◽  
Vol 86 (1-3) ◽  
pp. 291-299 ◽  
Author(s):  
Thomas L. Patterson ◽  
Brent T. Mausbach ◽  
Christine McKibbin ◽  
Sherry Goldman ◽  
Jesus Bucardo ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Psychosocial Intervention ◽  
Older Patients ◽  
Psychotic Disorders ◽  
Skills Training ◽  
Functional Adaptation ◽  
Middle Aged

Unattenuated Structural and Biochemical Alterations in the Rat Lung during Functional Adaptation to Ozone

1989 ◽  
Vol 140 (2) ◽  
pp. 493-501 ◽  
Author(s):  
Jeffrey S. Tepper ◽  
Daniel L. Costa ◽  
James R. Lehmann ◽  
Mary F. Weber ◽  
Gary E. Hatch
Keyword(s):  
Functional Adaptation ◽  
Rat Lung ◽  
Biochemical Alterations
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