scholarly journals Some reminiscences on studies of age-dependent and activity-dependent degeneration of sensory and motor endings in mammalian skeletal muscle

2015 ◽  
Vol 227 (2) ◽  
pp. 231-236
Author(s):  
Richard R. Ribchester
Keyword(s):  
Skeletal Muscle ◽  
Mammalian Skeletal Muscle ◽  
Age Dependent ◽  
Activity Dependent

scholarly journals Activity-Dependent Signaling Pathways Controlling Muscle Diversity and Plasticity

Physiology ◽  
2007 ◽  
Vol 22 (4) ◽  
pp. 269-278 ◽  
Author(s):  
Stefano Schiaffino ◽  
Marco Sandri ◽  
Marta Murgia
Keyword(s):  
Skeletal Muscle ◽  
Signaling Pathways ◽  
Fiber Type ◽  
Neuromuscular Diseases ◽  
Fiber Types ◽  
Mammalian Skeletal Muscle ◽  
Nerve Activity ◽  
Prevention And Treatment ◽  
Metabolic Properties ◽  
Activity Dependent

A variety of fiber types with different contractile and metabolic properties is present in mammalian skeletal muscle. The fiber-type profile is controlled by nerve activity via specific signaling pathways, whose identification may provide potential therapeutic targets for the prevention and treatment of metabolic and neuromuscular diseases.

Activity-Dependent Control of Circadian Rhythms in Mammalian Skeletal Muscle

2010 ◽  
Vol 42 ◽  
pp. 96-97
Author(s):  
Kenneth A. Dyar ◽  
Bert Blaauw ◽  
Stefano Ciciliot ◽  
Reimar Abraham ◽  
Giorgia Pallafacchina ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Circadian Rhythms ◽  
Mammalian Skeletal Muscle ◽  
Activity Dependent

scholarly journals MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Joseph C. Reynolds ◽  
Rochelle W. Lai ◽  
Jonathan S. T. Woodhead ◽  
James H. Joly ◽  
Cameron J. Mitchell ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Healthy Aging ◽  
Metabolic Stress ◽  
Muscle Metabolism ◽  
Physical Capacity ◽  
Physical Decline ◽  
Age Dependent ◽  
Exercise Induced ◽  
Muscle Homeostasis ◽  
Metabolic Fitness

AbstractHealthy aging can be promoted by enhanced metabolic fitness and physical capacity. Mitochondria are chief metabolic organelles with strong implications in aging that also coordinate broad physiological functions, in part, using peptides that are encoded within their independent genome. However, mitochondrial-encoded factors that actively regulate aging are unknown. Here, we report that mitochondrial-encoded MOTS-c can significantly enhance physical performance in young (2 mo.), middle-age (12 mo.), and old (22 mo.) mice. MOTS-c can regulate (i) nuclear genes, including those related to metabolism and proteostasis, (ii) skeletal muscle metabolism, and (iii) myoblast adaptation to metabolic stress. We provide evidence that late-life (23.5 mo.) initiated intermittent MOTS-c treatment (3x/week) can increase physical capacity and healthspan in mice. In humans, exercise induces endogenous MOTS-c expression in skeletal muscle and in circulation. Our data indicate that aging is regulated by genes encoded in both of our co-evolved mitochondrial and nuclear genomes.

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