scholarly journals Cellular proliferation in the nasal septal cartilage of juvenile minipigs

2014 ◽  
Vol 225 (6) ◽  
pp. 604-613 ◽  
Author(s):  
Ayman A. Al Dayeh ◽  
Susan W. Herring
Keyword(s):  
Cellular Proliferation ◽  
Septal Cartilage ◽  
Nasal Septal Cartilage

Skull growth in achondroplasic (cn) mice; a craniometric study

Development ◽  
1975 ◽  
Vol 33 (4) ◽  
pp. 1013-1022
Author(s):  
Rosemary J. Jolly ◽  
W. J. Moore
Keyword(s):  
Cranial Base ◽  
Septal Cartilage ◽  
Skull Morphology ◽  
Condylar Cartilage ◽  
Central Section ◽  
Condylar Process ◽  
Skull Growth ◽  
Anterior Extension ◽  
Posterior Extension ◽  
Nasal Septal Cartilage

Skull morphology in achondroplasic (cn/cn) mice was compared with that of normal siblings in order to determine the effects of this chondrodystrophy on skull growth, particular attention being given to dimensions reflecting growth at the synchondroses of the cranial base, the nasal septal cartilage and the condylar cartilage of the mandible. The central section of the cranial base (basicranial axis) was reduced by 25 %, the length of the viscerocranium by 18 % and the length of the condylar process by 11 %. The evidence indicates that these reductions are due to diminished growth at respectively the spheno-occipital and midsphenoidal synchondroses, the nasal septal cartilage and the condylar cartilage. The relative sizes of the reductions in cranial base, viscerocranium and condylar process suggest that the growth of synchondrotic and septal cartilages is diminished to a greater extent than that of condylar cartilage. This finding is in agreement with the observations that condylar cartilage, unlike synchondrotic and septal cartilage, grows by surface apposition and that the principal defect in cn/cn mice is a disturbance of interstitial cartilaginous growth. The posterior extension of the basicranial axis of the cn/cn mice was reduced by 14 % and the anterior extension by 2 %. The width of the cranial base was decreased by 9 % and the angle between the basicranial axis and its anterior extension was decreased by 3 %. The length of theneurocranium was reduced by 19 % in the cn/cn animals while the volume of the endocranial cavity was diminished by only 18 %. The latter reduction is less than would be expected from the cube relationship between volume and linear dimensions but is readily accounted for by the lack of reduction in the height or width of the neurocranium, the slight flattening of the cranial base and the doming of the neurocranial vault.

Tissue Engineered Human Septal Cartilage in a Murine Model

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P87-P88
Author(s):  
Angela Chang ◽  
Sage August ◽  
Barbara L Schumacher ◽  
Williams Gregory ◽  
Robert L Sah ◽  
...  
Keyword(s):  
Cell Viability ◽  
Murine Model ◽  
Three Dimensional ◽  
Alginate Beads ◽  
Septal Cartilage ◽  
Hematoxylin And Eosin ◽  
Matrix Production ◽  
Nasal Septal Cartilage

Problem Tissue engineering of human nasal septal cartilage represents an alternative technique for creating large quantities of autologous material for use in reconstructive surgery of the head and neck. Septal neocartilage constructs developed in vitro by the alginate method have demonstrated cartilaginous extracellular matrix production, but their biocompatibility and development in vivo remains largely unknown. Methods A murine model was used to examine the behavior of neocartilage constructs in vivo. Chondrocytes collected from donors undergoing septoplasty were expanded in monolayer and suspended in alginate beads for three-dimensional culture in media containing human serum and growth factors. After in vitro incubation for 5 weeks, the neocartilage constructs were implanted subcutaneously in the dorsum of athymic mice for 30 days (n=3). The mice were sacrificed and the constructs were explanted for assessment of cell viability, gross morphology, and histology. Results The mice survived and tolerated the implant well. Infection and extrusion were not observed. Neocartilage constructs maintained their general shape and size, and demonstrated cell viability after implantation. Explanted constructs were firm and opaque, sharing closer semblance to native septal tissue relative to the gelatinous, translucent pre-implant constructs. On hematoxylin and eosin staining, the explanted constructs exhibited distinct morphologies characteristic of native tissue, which were not observed in pre-implant constructs. Conclusion Neocartilage constructs are viable in an in vivo murine model. The morphologic and histologic features of explanted constructs more closely resemble native septal tissue when compared to pre-implant constructs. Significance Septal neocartilage constructs are biocompatible and demonstrate potential for in vivo maturation with eventual clinical application.

The width of nasal septal cartilage

2003 ◽  
Vol 129 (2) ◽  
pp. P256-P257
Author(s):  
A Ross
Keyword(s):  
Septal Cartilage ◽  
Nasal Septal Cartilage

scholarly journals Endoscopic Tympanoplasty Using Nasal Septal Cartilage Allograft

2017 ◽  
Vol 69 (2) ◽  
pp. 199-203 ◽  
Author(s):  
N. Ahilasamy ◽  
Badra Shanti ◽  
Sivaprakasam Rajasekaran
Keyword(s):  
Septal Cartilage ◽  
Nasal Septal Cartilage ◽  
Endoscopic Tympanoplasty

Controlling Incision-Induced Distortion of Nasal Septal Cartilage: A Model to Predict the Effect of Scoring of Rabbit Septa

2003 ◽  
Vol 111 (6) ◽  
pp. 1948-1957 ◽  
Author(s):  
Paul G. J. ten Koppel ◽  
Jan-Max van der Veen ◽  
David Hein ◽  
Fred van Keulen ◽  
Gerjo J. V. M. van Osch ◽  
...  
Keyword(s):  
Septal Cartilage ◽  
Nasal Septal Cartilage
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