scholarly journals Vestibular development in marsupials and monotremes

2013 ◽  
Vol 224 (4) ◽  
pp. 447-458 ◽  
Author(s):  
Ken W. S. Ashwell ◽  
Boaz Shulruf
Keyword(s):  
Vestibular Development

The role of Smad4 in vestibular development in mice

2010 ◽  
Vol 29 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Shi‐ming Yang ◽  
An‐chun Deng ◽  
De‐liang Huang ◽  
Jian‐he Sun ◽  
Guan Yang ◽  
...  
Keyword(s):  
Vestibular Development

Exposure to hypergravity during the preweaning but not postweaning period reduces vestibular-related stress responses in rats

2013 ◽  
Vol 115 (7) ◽  
pp. 1082-1087 ◽  
Author(s):  
Chikara Abe ◽  
Yoichi Ueta ◽  
Hironobu Morita
Keyword(s):  
Stress Response ◽  
Stress Responses ◽  
Adrenocorticotropic Hormone ◽  
Motor Coordination ◽  
Plasma Corticosterone ◽  
Hypothalamic Nucleus ◽  
Gravitational Forces ◽  
Vestibular Lesion ◽  
Related Stress ◽  
Vestibular Development

Gravitational forces, including hypergravity or microgravity, induce plasticity of vestibular-related functions. These functions are not easily reversed if exposure to the gravitational forces occurs during vestibular development. In the present study, we hypothesized that vestibular-related stress responses might be suppressed in rats exposed to hypergravity during the vestibular development period. We exposed the rats to 2 g (hypergravity) during the preweaning (BW-HG; embryonic day 14 to postnatal week 3) or postweaning (AW-HG; postnatal weeks 4–6) periods. After recovery for 4 wk at 1 g, we conducted rotarod tests and then exposed the rats to 2 g for 90 min. In BW-HG rats, vestibular-related motor coordination on the rotarod test was partially, but not fully, restored to the level of AW-HG rats or rats raised at 1 g (1-G group). Loading-induced plasma adrenocorticotropic hormone and corticosterone levels were significantly suppressed in BW-HG and in rats with a vestibular lesion compared with AW-HG and 1-G rats. Arginine vasopressin and Fos expression levels in the paraventricular hypothalamic nucleus were also significantly lower in BW-HG and vestibular lesion rats than in AW-HG and 1-G rats. By contrast, there was no difference in the electrical foot shock-induced increase in plasma corticosterone among the experimental groups, suggesting that the nonvestibular-related stress response was not suppressed by exposure to 2 g during preweaning. These results indicated that exposure to hypergravity during preweaning specifically suppressed the vestibular-related stress response, and this suppression did not recover after 4 wk at 1 g.

Vestibular Development

2014 ◽  
pp. 115-125
Author(s):  
Hiroko Torii ◽  
Akiko Taura
Keyword(s):  
Vestibular Development

scholarly journals A critical period for functional vestibular development in zebrafish

2002 ◽  
Vol 223 (2) ◽  
pp. 285-291 ◽  
Author(s):  
Stephen J. Moorman ◽  
Rodolfo Cordova ◽  
Sarah A. Davies
Keyword(s):  
Critical Period ◽  
Vestibular Development

Corrigendum to “The role of Smad4 in vestibular development in mice” [Int. J. Dev. Neurosci. 29 (2011) 15–23]

2011 ◽  
Vol 29 (7) ◽  
pp. 783-783
Author(s):  
Shi‐ming Yang ◽  
An‐chun Deng ◽  
De‐liang Huang ◽  
Jian‐he Sun ◽  
Guan Yang ◽  
...  
Keyword(s):  
Vestibular Development

Effects of microgravity on vestibular development and function in rats: Genetics and environment

2000 ◽  
Vol 4 (3) ◽  
pp. 215-221 ◽  
Author(s):  
April E. Ronca ◽  
Bernd Fritzsch ◽  
Jeffrey R. Alberts ◽  
Laura L. Bruce
Keyword(s):  
And Function ◽  
Vestibular Development

scholarly journals Implementing the chick embryo model to study vestibular developmental disorders

2019 ◽  
Vol 122 (6) ◽  
pp. 2272-2283 ◽  
Author(s):  
Hayley E. Seal ◽  
Sigmund J. Lilian ◽  
Anastas Popratiloff ◽  
June C. Hirsch ◽  
Kenna D. Peusner
Keyword(s):  
Inner Ear ◽  
Developmental Disorders ◽  
Neural Circuit ◽  
Semicircular Canals ◽  
Surgical Approaches ◽  
Vestibular Disorders ◽  
Computed Tomography Images ◽  
Anterior Posterior ◽  
Vestibular Development ◽  
Anterior Posterior Axis

Children with congenital vestibular disorders show delayed motor development and challenges in maintaining posture and balance. Computed tomography images reveal that these children have abnormal inner ears in the form of a sac, with the semicircular canals missing or truncated. Little is known about how this inner ear abnormality affects central vestibular development. At present, mice with the chromodomain helicase DNA-binding protein 7 mutation are the most common model for studying congenital vestibular disorders, despite forming multiple diverse inner ear phenotypes and inducing abnormal cerebellar and visual system development. To identify the effects of a sac-like inner ear on central vestibular development, we have designed and implemented a new model, the anterior-posterior axis rotated otocyst (ARO) chick, which forms a sac-like inner ear in 85% of cases. The ARO chick is produced by anterior-posterior rotation of the otocyst at embryonic day 2. Here, we describe for the first time the 15% of ARO chicks that form three small semicircular canals and rename the ARO chicks forming sacs (ARO/s chicks). The basic features of the vestibular sensory organs in ARO/s chicks are similar to those found in patients’ sacs, and ARO/s hatchlings experience balance and walking problems like patients. Thus, ARO/s chicks have a reproducible inner ear phenotype without abnormalities in vestibular-related structures, making the model a relatively simple one to evaluate the relationship between the sac-like inner ear pathology and formation of the central vestibular neural circuitry. Here, we describe unpublished details on the surgical approaches to produce ARO chicks, including pitfalls and difficulties to avoid. NEW & NOTEWORTHY This paper describes simple techniques for chick otocyst rotation resulting in a sac-like inner ear (85%), the common phenotype in congenital vestibular disorders. We now describe anterior-posterior axis rotated otocyst chicks, which form three small canals (15%), and rename chicks forming a sac (ARO/s chicks). Basic protocols and potential complications of otocyst rotation are described. With the use of ARO/s chicks, it will be possible to determine how the vestibular neural circuit is modified by sac-like inner ear formation.

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