scholarly journals Conditional ablation of vasopressin‐synthesizing neurons in transgenic rats

2021 ◽  
Author(s):  
Jun Watanabe ◽  
Yuki Takayanagi ◽  
Masahide Yoshida ◽  
Tatsuya Hattori ◽  
Michiko Saito ◽  
...  
Keyword(s):  
Transgenic Rats

Potential of Motor Neurons in the Nucleus Ambiguus ∼ Utilizing Nestin-EGFP Transgenic Rats

2007 ◽  
Vol 58 (2) ◽  
pp. 193-193
Author(s):  
T. Takaoka ◽  
A. Shiotani ◽  
K. Saito ◽  
M. Tomifuji ◽  
Y. Mori ◽  
...  
Keyword(s):  
Motor Neurons ◽  
Nucleus Ambiguus ◽  
Transgenic Rats

Impaired Estrogen Sensitivity in Bone by Inhibiting Both Estrogen Receptor a and b Pathways*

2020 ◽  
Author(s):  
Lungwani Muungo
Keyword(s):  
Bone Mineral Density ◽  
Estrogen Receptor ◽  
Bone Loss ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Female Rats ◽  
Wild Type ◽  
Mineral Density ◽  
Transgenic Rats ◽  
Estrogen Sensitivity

Although it is well established that estrogen deficiencycauses osteoporosis among the postmenopausalwomen, the involvement of estrogen receptor (ER) in itspathogenesis still remains uncertain. In the presentstudy, we have generated rats harboring a dominantnegative ERa, which inhibits the actions of not only ERabut also recently identified ERb. Contrary to our expectation,the bone mineral density (BMD) of the resultingtransgenic female rats was maintained at the same levelwith that of the wild-type littermates when sham-operated.In addition, ovariectomy-induced bone loss wasobserved almost equally in both groups. Strikingly, however,the BMD of the transgenic female rats, after ovariectomized,remained decreased even if 17b-estradiol(E2) was administrated, whereas, in contrast, the decreaseof littermate BMD was completely prevented byE2. Moreover, bone histomorphometrical analysis ofovariectomized transgenic rats revealed that the higherrates of bone turnover still remained after treatmentwith E2. These results demonstrate that the preventionfrom the ovariectomy-induced bone loss by estrogen ismediated by ER pathways and that the maintenanceof BMD before ovariectomy might be compensatedby other mechanisms distinct from ERa and ERbpathways.

scholarly journals Role of HDL phospholipid in efflux of cell cholesterol to whole serum: studies with human apoA-I transgenic rats.

1996 ◽  
Vol 37 (8) ◽  
pp. 1704-1711
Author(s):  
N Fournier ◽  
M de la Llera Moya ◽  
B F Burkey ◽  
J B Swaney ◽  
J. Paterniti ◽  
...  
Keyword(s):  
Transgenic Rats

Role of endogenous regucalcin in bone metabolism: Bone loss is induced in regucalcin transgenic rats

2002 ◽  
Author(s):  
Masayoshi Yamaguchi ◽  
H. Misawa ◽  
S. Uchiyama ◽  
Y. Morooka ◽  
Y. Tsurusaki
Keyword(s):  
Bone Loss ◽  
Bone Metabolism ◽  
Transgenic Rats

scholarly journals Lactobacillus GG prevents recurrence of colitis in HLA-B27 transgenic rats after antibiotic treatment

2000 ◽  
Vol 118 (4) ◽  
pp. A814 ◽  
Author(s):  
Levinus A. Dieleman ◽  
Marije S. Goerres ◽  
Annemarie Arends ◽  
Dave Sprengers ◽  
Robin L. Vamey ◽  
...  
Keyword(s):  
Antibiotic Treatment ◽  
Hla B27 ◽  
Transgenic Rats ◽  
Lactobacillus Gg

scholarly journals Cardiac remodeling during and after renin–angiotensin system stimulation in Cyp1a1-Ren2 transgenic rats

2013 ◽  
Vol 15 (1) ◽  
pp. 69-81 ◽  
Author(s):  
Bart FJ Heijnen ◽  
Leonie PJ Pelkmans ◽  
AH Jan Danser ◽  
Ingrid M Garrelds ◽  
John J Mullins ◽  
...  
Keyword(s):  
Cardiac Remodeling ◽  
Renin Angiotensin System ◽  
Transgenic Rats ◽  
Angiotensin System ◽  
Renin Angiotensin
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