Role of insulin in the neuroendocrine control of reproduction

2021 ◽  
Vol 33 (4) ◽  
Author(s):  
Maggie C. Evans ◽  
Jennifer W. Hill ◽  
Greg M. Anderson
Keyword(s):  
Neuroendocrine Control

scholarly journals Characterization of the Potent Luteinizing Hormone-Releasing Activity of KiSS-1 Peptide, the Natural Ligand of GPR54

Endocrinology ◽  
2005 ◽  
Vol 146 (1) ◽  
pp. 156-163 ◽  
Author(s):  
V. M. Navarro ◽  
J. M. Castellano ◽  
R. Fernández-Fernández ◽  
S. Tovar ◽  
J. Roa ◽  
...  
Keyword(s):  
Excitatory Amino Acid ◽  
Hypogonadotropic Hypogonadism ◽  
Mrna Levels ◽  
Central Administration ◽  
Experimental Conditions ◽  
Gonadotropin Secretion ◽  
Neuroendocrine Control ◽  
Lh Secretion

Loss-of-function mutations of the gene encoding GPR54, the putative receptor for the KiSS-1-derived peptide metastin, have been recently associated with hypogonadotropic hypogonadism, in both rodents and humans. Yet the actual role of the KiSS-1/GPR54 system in the neuroendocrine control of gonadotropin secretion remains largely unexplored. To initiate such analysis, the effects of KiSS-1 peptide on LH secretion were monitored using in vivo and in vitro settings under different experimental conditions. Central intracerebroventricular administration of KiSS-1 peptide potently elicited LH secretion in vivo over a range of doses from 10 pmol to 1 nmol. The effect of centrally injected KiSS-1 appeared to be mediated via the hypothalamic LHRH. However, no effect of central administration of KiSS-1 was detected on relative LHRH mRNA levels. Likewise, systemic (ip and iv) injection of KiSS-1 markedly stimulated LH secretion. This effect was similar in terms of maximum response to that of central administration of KiSS-1 and might be partially attributed to its ability to stimulate LH secretion directly at the pituitary. Finally, the LH-releasing activity of KiSS-1 was persistently observed after blockade of endogenous excitatory amino acid and nitric oxide pathways, i.e. relevant neurotransmitters in the neuroendocrine control of LH secretion. In summary, our results provide solid evidence for a potent stimulatory effect of KiSS-1 on LH release, acting at central levels (likely the hypothalamus) and eventually at the pituitary, and further document a novel role of the KiSS-1/GPR54 system as a relevant downstream element in the neuroendocrine network governing LH secretion.

Role of Melatonin in the Mechanisms Underlying Neuroendocrine Control of the Hypothalamo-Hypophyseal-Thyroid Axis

2008 ◽  
Vol 40 (5-6) ◽  
pp. 393-403 ◽  
Author(s):  
L. A. Bondarenko ◽  
N. N. Sotnik ◽  
A. R. Gevorkyan
Keyword(s):  
Neuroendocrine Control ◽  
Thyroid Axis

scholarly journals Temporal Changes Occur in the Neuroendocrine Control of Gonadotropin Secretion in Aging Female Rats: Role of Progesterone1

2004 ◽  
Vol 71 (3) ◽  
pp. 845-852 ◽  
Author(s):  
Houng-Wei Tsai ◽  
Philip S. LaPolt ◽  
Angelica P. Olcott ◽  
John K.H. Lu
Keyword(s):  
Temporal Changes ◽  
Female Rats ◽  
Gonadotropin Secretion ◽  
Neuroendocrine Control

scholarly journals Gonadectomy and blood sampling procedures in small size teleost models

2020 ◽  
Author(s):  
Muhammad Rahmad Royan ◽  
Shinji Kanda ◽  
Daichi Kayo ◽  
Weiyi Song ◽  
Wei Ge ◽  
...  
Keyword(s):  
Sex Steroids ◽  
Teleost Fish ◽  
Oryzias Latipes ◽  
Blood Sampling ◽  
Model Organisms ◽  
Small Fish ◽  
Neuroendocrine Control ◽  
Sampling Procedures ◽  
The Brain

AbstractSex steroids, produced by the gonads, play an essential role in the neuroendocrine control of reproduction in all vertebrates by providing feedback to the brain and pituitary. Sex steroids also play an important role in tissue plasticity by regulating cell proliferation in several tissues including the brain and the pituitary. Therefore, investigating the role of sex steroids and mechanisms by which they act is crucial to better understand both feedback mechanism and tissue plasticity. Teleost fish, which possess a higher degree of tissue plasticity and variations in reproduction strategies compared to mammals, appear to be useful models to investigate these questions. The removal of the main source of sex steroid production using gonadectomy together with blood sampling to measure steroid levels, have been well-established and fairly feasible in bigger fish and are powerful techniques to investigate the role and effects of sex steroids. However, small fish such as zebrafish and medaka, which are particularly good model organisms considering the well-developed genetic toolkit and the numerous protocols available to investigate their biology and physiology, raise challenges for applying such protocols due to their small size. Here, we demonstrate the step-by-step procedure of gonadectomy in both males and females followed by blood sampling in a small sized teleost model, the Japanese medaka (Oryzias latipes). The use of these procedures combined with the other advantages of using these small teleost models will greatly improve our understanding of feedback mechanisms in the neuroendocrine control of reproduction and tissue plasticity provided by sex steroids in vertebrates.SUMMARYThe article describes a quick protocol to gonadectomize and sample blood from small teleost fish, using medaka (Oryzias latipes) as a model, to investigate the role of sex steroids in animal physiology.

The Role of the Septal Area in the Neuroendocrine Control of Growth in the Adult Golden Hamster

1977 ◽  
Vol 23 (3) ◽  
pp. 133-150 ◽  
Author(s):  
K.T. Borer ◽  
R.P. Kelch ◽  
M.P. White ◽  
L. Dolson ◽  
L.R. Kuhns
Keyword(s):  
Golden Hamster ◽  
Septal Area ◽  
Neuroendocrine Control
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