Obesity and regulation of human placental lactogen production in pregnancy

2020 ◽  
Vol 32 (11) ◽  
Author(s):  
Peter A. Cattini ◽  
Yan Jin ◽  
Jessica S. Jarmasz ◽  
Noshin Noorjahan ◽  
Margaret E. Bock
Keyword(s):  
Placental Lactogen ◽  
Human Placental Lactogen ◽  
In Pregnancy

Measurement of Human Growth Hormone in Pregnancy and Correlation with Human Placental Lactogen

1971 ◽  
Vol 32 (3) ◽  
pp. 328-332 ◽  
Author(s):  
SURENDRA K. VARMA ◽  
PETER H. SONKSEN ◽  
KAMLESH VARMA ◽  
J. STUART SOELDNER ◽  
HERBERT A. SELENKOW ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Placental Lactogen ◽  
Human Placental Lactogen ◽  
In Pregnancy

Studies on the Metabolism of Human Placental Lactogen in Pregnancy

1970 ◽  
Vol 2 (05) ◽  
pp. 265-267 ◽  
Author(s):  
P. Keller ◽  
C. Gerber ◽  
H. Greub ◽  
W. Schreiner
Keyword(s):  
Placental Lactogen ◽  
Human Placental Lactogen ◽  
In Pregnancy

Enhancement of plasma corticotropin-releasing hormone in pregnancy-induced hypertension

1990 ◽  
Vol 122 (6) ◽  
pp. 711-714 ◽  
Author(s):  
W. Jeske ◽  
P. Soszyński ◽  
E. Lukaszewicz ◽  
R. Dȩbski ◽  
W. Latoszewska ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Placental Tissue ◽  
Normal Pregnancy ◽  
Placental Lactogen ◽  
Control Group ◽  
Pregnancy Induced Hypertension ◽  
Human Placental Lactogen ◽  
Induced Hypertension ◽  
In Pregnancy

Abstract. The role of a high CRH level in normal pregnancy remains unknown. Therefore we evaluated the concentrations of CRH and the related hormones in patients with pregnancy-induced hypertension. Fourteen women with pregnancy-induced hypertension, aged 20-39, at 30-39 gestational week, were investigated. The control group consisted of 20 healthy pregnant women matched according to gestational age. Plasma CRH, β-endorphin-like immunoreactivity, cortisol, and human placental lactogen were measured by radioimmunoassay, ACTH by an immunoradiometric method. It was found that in hypertensive patients the mean CRH concentration was significantly higher (4257±840 (sem) ng/l) than that in healthy pregnant women (1083±227 ng/l, p<0.001). The concentration of ACTH, however, was only slightly higher 65.0±6.0 vs 50.7±2.5 ng/l, p<0.025, whereas the differences in β-endorphin, cortisol and human placental lactogen were not significant. In both groups there was no correlation between the CRH level and those of the related hormones. In healthy pregnant women the CRH level closely correlated with gestational age (r=0.76, p<0.001), whereas in patients with hypertension no such correlation was present (r=0.29). We assume that the marked enhancement of plasma CRH in pregnancy-induced hypertension is probably caused by its decreased breakdown in ischemic placental tissue, but its increased synthesis in the placenta and its indirect counterregulatory hypotensive role must also be considered.

HUMAN PLACENTAL LACTOGEN IN PREGNANCY

The Lancet ◽  
1977 ◽  
Vol 310 (8039) ◽  
pp. 662 ◽  
Author(s):  
Antonio Ghionni
Keyword(s):  
Placental Lactogen ◽  
Human Placental Lactogen ◽  
In Pregnancy

Enzyme-linked immunoassay for placental lactogen in human serum.

1980 ◽  
Vol 26 (6) ◽  
pp. 745-749
Author(s):  
D J MacDonald ◽  
K M Nicol ◽  
A Belfield ◽  
M M Shah ◽  
D S Mack
Keyword(s):  
Horseradish Peroxidase ◽  
Human Serum ◽  
Peroxidase Activity ◽  
Coefficient Of Variation ◽  
Placental Lactogen ◽  
Human Placental Lactogen ◽  
Placental Function ◽  
Discernible Effect ◽  
In Pregnancy

Abstract We describe an enzyme-linked immunoassay for measuring human placental lactogen (HPL) in serum. After suitable dilution, sera are pipetted into the wells of polyvinyl microtitre plates previously coated with anti-HPL. After incubation the sera are decanted, and replaced by a conjugate of horseradish peroxidase and anti-HPL. An amount of enzyme proportional to the concentration of HPL in the serum is bound to the wells via an antibody—HPL—antibody bridge. Peroxidase activity is measured by oxidation of o-phenylenediamine, the resulting color being related to the concentration of HPL. Results correlate well with those by radioimmunoassay (r = 0.96). Our between-assay coefficient of variation was 13%; no discernible effect of protein was observed. This 4-h assay can be used to monitor placental function in pregnancy.

Enzyme-linked immunoassay for placental lactogen in human serum.

1980 ◽  
Vol 26 (6) ◽  
pp. 745-749 ◽  
Author(s):  
D J MacDonald ◽  
K M Nicol ◽  
A Belfield ◽  
M M Shah ◽  
D S Mack
Keyword(s):  
Horseradish Peroxidase ◽  
Human Serum ◽  
Peroxidase Activity ◽  
Coefficient Of Variation ◽  
Placental Lactogen ◽  
Human Placental Lactogen ◽  
Placental Function ◽  
Discernible Effect ◽  
In Pregnancy

Abstract We describe an enzyme-linked immunoassay for measuring human placental lactogen (HPL) in serum. After suitable dilution, sera are pipetted into the wells of polyvinyl microtitre plates previously coated with anti-HPL. After incubation the sera are decanted, and replaced by a conjugate of horseradish peroxidase and anti-HPL. An amount of enzyme proportional to the concentration of HPL in the serum is bound to the wells via an antibody—HPL—antibody bridge. Peroxidase activity is measured by oxidation of o-phenylenediamine, the resulting color being related to the concentration of HPL. Results correlate well with those by radioimmunoassay (r = 0.96). Our between-assay coefficient of variation was 13%; no discernible effect of protein was observed. This 4-h assay can be used to monitor placental function in pregnancy.

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